Laparoscopically assisted extrahepatic bile duct excision with ductoplasty and a widened hepaticojejunostomy for complicated hepatobiliary dilatation

2014 ◽  
Vol 30 (6) ◽  
pp. 593-598 ◽  
Author(s):  
Suolin Li ◽  
Wenbo Wang ◽  
Zengwen Yu ◽  
Weili Xu
Keyword(s):  
Bile Duct ◽  
Extrahepatic Bile Duct ◽  
Duct Excision

scholarly journals A rare case of eosinophilic cholangiopathy

2020 ◽  
Vol 34 ◽  
pp. 205873842094175
Author(s):  
Wenya Li ◽  
Feizhao Jiang ◽  
Xiaoxiao Li ◽  
Hong Li ◽  
Zhihai Zheng
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Bile Duct ◽  
Rare Case ◽  
Extrahepatic Bile Duct ◽  
Definitive Diagnosis ◽  
Malignant Diseases ◽  
Peripheral Eosinophilia ◽  
Number Of Patients ◽  
Accurate Treatment ◽  
Duct Excision

Eosinophilic cholangiopathy is termed as a rare, benign, and self-limiting disease. Moreover, the interference of malignant tumor to diagnosis and the changing process of disease make the accurate treatment proposal challenging. A significant number of patients require surgery for the definitive diagnosis and resolution of symptoms. We put forward a case of eosinophilic cholangiopathy infiltrating the gallbladder and bile duct with bone marrow involved, coupled with peripheral eosinophilia. The patient underwent a successful treatment using laparoscopic cholecystectomy and steroids, instead of extrahepatic bile duct excision with Roux-en-Y hepaticojejunostomy. The patient gets an accurate treatment in a minimally invasive manner. In conclusion, surgery refers to not only a diagnostic methodology but also a treatment. When the bile duct and gallbladder are involved at the same time, and cannot distinguish benign and malignant diseases, laparoscopic cholecystectomy is feasible, the effect is the same, and the symptoms of eosinophilic cholecystitis are relieved.

scholarly journals Heterotopic Pancreas within the Proximal Hepatic Duct, Containing Intraductal Papillary Mucinous Neoplasm

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Alistair J. Lawrence ◽  
Aducio Thiessen ◽  
Amy Morse ◽  
A. M. James Shapiro
Keyword(s):  
Bile Duct ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Extrahepatic Bile Duct ◽  
Hepatic Duct ◽  
Heterotopic Pancreas ◽  
Hepatic Bile ◽  
Mucinous Neoplasm ◽  
First Case ◽  
Duct Excision ◽  
Left Hepatic Lobectomy

We report a unique first case of benign heterotopic pancreas arising within the proximal hepatic bile duct, containing a focus of intraductal papillary mucinous neoplasm (IPMN). The condition was diagnosed on pathological explant after left hepatic lobectomy with total extrahepatic bile duct excision.

scholarly journals GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lucas D. Ward ◽  
Ho-Chou Tu ◽  
Chelsea B. Quenneville ◽  
Shira Tsour ◽  
Alexander O. Flynn-Carroll ◽  
...  
Keyword(s):  
Bile Duct ◽  
Extrahepatic Bile Duct ◽  
Association Studies ◽  
Missense Variant ◽  
Deficiency Anemia ◽  
Genome Wide Association Studies ◽  
Loss Of Function ◽  
Extrahepatic Bile Duct Cancer ◽  
Hepatocellular Damage ◽  
Increased Risk

AbstractUnderstanding mechanisms of hepatocellular damage may lead to new treatments for liver disease, and genome-wide association studies (GWAS) of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum activities have proven useful for investigating liver biology. Here we report 100 loci associating with both enzymes, using GWAS across 411,048 subjects in the UK Biobank. The rare missense variant SLC30A10 Thr95Ile (rs188273166) associates with the largest elevation of both enzymes, and this association replicates in the DiscovEHR study. SLC30A10 excretes manganese from the liver to the bile duct, and rare homozygous loss of function causes the syndrome hypermanganesemia with dystonia-1 (HMNDYT1) which involves cirrhosis. Consistent with hematological symptoms of hypermanganesemia, SLC30A10 Thr95Ile carriers have increased hematocrit and risk of iron deficiency anemia. Carriers also have increased risk of extrahepatic bile duct cancer. These results suggest that genetic variation in SLC30A10 adversely affects more individuals than patients with diagnosed HMNDYT1.

scholarly journals Etiological classification and treatment strategies for secondary bile duct dilatation

2020 ◽  
pp. 153537022096676
Author(s):  
Yunfu Lv ◽  
Ning Liu ◽  
Hongfei Wu ◽  
Zhuori Li
Keyword(s):  
Bile Duct ◽  
Extrahepatic Bile Duct ◽  
Treatment Strategies ◽  
Extensive Literature ◽  
Common Condition ◽  
Endoscopic Dilation ◽  
Biliary Strictures ◽  
Bile Duct Dilatation ◽  
Duct Dilatation ◽  
Classification And Treatment

Secondary intra- and extrahepatic bile duct dilatation is a very common condition that can be caused by several diseases. However, it has been rarely discussed in the specialized literature. Moreover, no distinct etiology can be determined in some cases, which hampers the diagnosis and treatment. Here, we discuss the etiological classification and treatment strategies of secondary intra- and extrahepatic bile duct dilatation based on an extensive literature review, as well as our experimental research and clinical experience. The etiology of secondary intra- and extrahepatic bile duct dilatation can be classified in different ways. From a clinicopathological perspective, it can be classified into obstruction-, lesion-, and compression-induced dilatation. Treatment varies depending on the cause. For example, endoscopic dilation or stenting is used for biliary strictures, laparoscopic choledochectomy for stone removal, and resection for cholangiocarcinoma.

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