Cognitive and functional deficits are associated with white matter abnormalities in two independent cohorts of patients with schizophrenia

Abstract Background Significant evidence links white matter (WM) microstructural abnormalities to cognitive impairment in schizophrenia (SZ), but the relationship of these abnormalities with functional outcome remains unclear. Methods In two independent cohorts (C1, C2), patients with SZ were divided into two subgroups: patients with higher cognitive performance (SZ-HCP-C1, n = 25; SZ-HCP-C2, n = 24) and patients with lower cognitive performance (SZ-LCP-C1, n = 25; SZ-LCP-C2, n = 24). Healthy controls (HC) were included in both cohorts (HC-C1, n = 52; HC-C2, n = 27). We compared fractional anisotropy (FA) of the whole-brain WM skeleton between the three groups (SZ-LCP, SZ-HCP, HC) by a whole-brain exploratory approach and an atlas-defined WM regions-of-interest approach via tract-based spatial statistics. In addition, we explored whether FA values were associated with Global Assessment of Functioning (GAF) scores in the SZ groups. Results In both cohorts, mean FA values of whole-brain WM skeleton were significantly lower in the SCZ-LCP group than in the SCZ-HCP group. Whereas in C1 the FA of the frontal part of the left inferior fronto-occipital fasciculus (IFOF) was positively correlated with GAF score, in C2 the FA of the temporal part of the left IFOF was positively correlated with GAF score. Conclusions We provide robust evidence for WM microstructural abnormalities in SZ. These abnormalities are more prominent in patients with low cognitive performance and are associated with the level of functioning.

Download Full-text

Relationship of Silent Cerebral Infarctions and White Matter Hyperintensities to Cognitive Performance in the Framingham Offspring Study

Alzheimer Disease & Associated Disorders ◽

10.1097/00002093-200607001-00020 ◽

2006 ◽

Vol 20 (Supplement 2) ◽

pp. S101 ◽

Cited By ~ 1

Author(s):

Karrah Q. Bristow ◽

Rhoda Au ◽

Joseph M. Massaro ◽

Sudha Seshadri ◽

Philip A. Wolf ◽

...

Keyword(s):

White Matter ◽

Cognitive Performance ◽

White Matter Hyperintensities ◽

Relationship Of

Download Full-text

Assessing Stressors Related to Migration in Patients With Psychiatric Disorders

European Journal of Psychological Assessment ◽

10.1027/1015-5759/a000106 ◽

2012 ◽

Vol 28 (4) ◽

pp. 262-269 ◽

Cited By ~ 5

Author(s):

Matthias Johannes Müller ◽

Suzan Kamcili-Kubach ◽

Songül Strassheim ◽

Eckhardt Koch

Keyword(s):

Interrater Reliability ◽

Item Analysis ◽

Global Assessment Of Functioning ◽

Family Conflicts ◽

Response Options ◽

Reliability Indices ◽

Dsm Iv ◽

Functional Relevance ◽

Sum Scores ◽

Gaf Scores

A 10-item instrument for the assessment of probable migration-related stressors was developed based on previous work (MIGSTR10) and interrater reliability was tested in a chart review study. The MIGSTR10 and nine nonspecific stressors of the DSM-IV Axis IV (DSMSTR9) were put into a questionnaire format with categorical and dimensional response options. Charts of 100 inpatients (50 Turkish migrants [MIG], 50 native German patients [CON]) with affective or anxiety disorder were reviewed by three independent raters and MIGSTR10, DSMSTR9, and Global Assessment of Functioning scale (GAF) scores were obtained. Interrater reliability indices (ICC) of items and sum scores were calculated. The prevalence of single migration-related stressors in MIG ranged from 15% to 100% (CON 0–92%). All items of the MIGSTR10 (ICC 0.58–0.92) and the DSMSTR9 (ICC 0.56–0.96) reached high to very high interrater agreement (p < .0005). The item analysis of the MIGSTR10 revealed sufficient internal consistency (Cronbach’s α = 0.68/0.69) and only one item (“family conflicts”) without substantial correlation with the remaining scale. Correlation analyses showed a significant overlap of dimensional MIGSTR10 scores (r² = 0.25; p < .01) and DSMSTR9 scores (r² = 9%; p < .05) with GAF scores in MIG indicating functional relevance. MIGSTR10 is considered a feasible, economic, and reliable instrument for the assessment of stressors potentially related to migration.

Download Full-text

Moderating factors in the relationship of objectification to cognitive performance: Can self-affirmation trump self-consciousness?

PsycEXTRA Dataset ◽

10.1037/e579292006-001 ◽

2006 ◽

Author(s):

Sonya K. Bettendorf ◽

Jean Denious ◽

Nancy Felipe-Russo

Keyword(s):

Cognitive Performance ◽

Moderating Factors ◽

Relationship Of ◽

The Relationship

Download Full-text

CHARACTERIZATION OF COGNITIVE PERFORMANCE, GRAY MATTER VOLUME AND WHITE MATTER MICROSTRUCTURE IN COGNITIVELY UNIMPAIRED ADULTS WITH INSOMNIA SYMPTOMS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.4549 ◽

2019 ◽

Vol 15 (7) ◽

pp. P207-P209

Author(s):

Oriol Grau-Rivera ◽

Grégory Operto ◽

Carles Falcon ◽

Raffaele Cacciaglia ◽

Gonzalo Sánchez-Benavides ◽

...

Keyword(s):

White Matter ◽

Cognitive Performance ◽

Gray Matter ◽

Gray Matter Volume ◽

Matter Volume ◽

White Matter Microstructure ◽

Insomnia Symptoms

Download Full-text

Whole-brain 3D MR fingerprinting brain imaging: clinical validation and feasibility to patients with meningioma

Magnetic Resonance Materials in Physics Biology and Medicine ◽

10.1007/s10334-021-00924-1 ◽

2021 ◽

Author(s):

Thomaz R. Mostardeiro ◽

Ananya Panda ◽

Robert J. Witte ◽

Norbert G. Campeau ◽

Kiaran P. McGee ◽

...

Keyword(s):

White Matter ◽

Statistical Significance ◽

Relaxation Times ◽

Brain Structures ◽

Centrum Semiovale ◽

In Vivo Evaluation ◽

Whole Brain ◽

Mean Values ◽

Caudate Head

Abstract Purpose MR fingerprinting (MRF) is a MR technique that allows assessment of tissue relaxation times. The purpose of this study is to evaluate the clinical application of this technique in patients with meningioma. Materials and methods A whole-brain 3D isotropic 1mm3 acquisition under a 3.0T field strength was used to obtain MRF T1 and T2-based relaxometry values in 4:38 s. The accuracy of values was quantified by scanning a quantitative MR relaxometry phantom. In vivo evaluation was performed by applying the sequence to 20 subjects with 25 meningiomas. Regions of interest included the meningioma, caudate head, centrum semiovale, contralateral white matter and thalamus. For both phantom and subjects, mean values of both T1 and T2 estimates were obtained. Statistical significance of differences in mean values between the meningioma and other brain structures was tested using a Friedman’s ANOVA test. Results MR fingerprinting phantom data demonstrated a linear relationship between measured and reference relaxometry estimates for both T1 (r2 = 0.99) and T2 (r2 = 0.97). MRF T1 relaxation times were longer in meningioma (mean ± SD 1429 ± 202 ms) compared to thalamus (mean ± SD 1054 ± 58 ms; p = 0.004), centrum semiovale (mean ± SD 825 ± 42 ms; p < 0.001) and contralateral white matter (mean ± SD 799 ± 40 ms; p < 0.001). MRF T2 relaxation times were longer for meningioma (mean ± SD 69 ± 27 ms) as compared to thalamus (mean ± SD 27 ± 3 ms; p < 0.001), caudate head (mean ± SD 39 ± 5 ms; p < 0.001) and contralateral white matter (mean ± SD 35 ± 4 ms; p < 0.001) Conclusions Phantom measurements indicate that the proposed 3D-MRF sequence relaxometry estimations are valid and reproducible. For in vivo, entire brain coverage was obtained in clinically feasible time and allows quantitative assessment of meningioma in clinical practice.

Download Full-text