Polymarker, HLA-DQA1 and D1S80 allele data in a Zimbabwean Black sample population

This archived data study used results from the New York City Community Health Survey to explore the relationship between interpersonal violence among female sexual minorities (FSM) and their levels of alcohol and tobacco use. A total of 92 FSM were included in the sample population. There was a significant difference in the mean number of alcoholic drinks consumed between FSM who reported past experience of interpersonal violence and those who did not. No difference was found in levels of tobacco use between FSM who reported interpersonal violence and those who did not. Results of the present study support current research indicating FSM may be at increased risk for elevated alcohol use and respective negative life outcomes related to the experience of interpersonal violence.

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Faculty Opinions recommendation of HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725337647.793503683 ◽

2015 ◽

Author(s):

Gerd Kullak-Ublick

Keyword(s):

Breast Cancer ◽

Risk Factor ◽

Advanced Breast Cancer ◽

Advanced Breast ◽

Major Risk Factor ◽

Hla Dqa1

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Faculty Opinions recommendation of Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9091961.9833054 ◽

2011 ◽

Author(s):

Susan Quaggin ◽

Joseph Ly

Keyword(s):

Membranous Nephropathy ◽

Idiopathic Membranous Nephropathy ◽

Hla Dqa1

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Estudio de la interacción entre el Virus del Papiloma Humano (VPH), agentes infecciosos asociados y la constitución genética del hospedador en la transformación neoplásica en células de cuello uterino

10.35537/10915/4590 ◽

2003 ◽

Author(s):

◽

Martín Carlos Abba

Keyword(s):

Herpes Simplex ◽

Chlamydia Trachomatis ◽

Principal Factor ◽

Codon 72 ◽

Arms Pcr ◽

El Sistema ◽

Hla Dqa1 ◽

Los Grupos

El Virus del Papiloma Humano (VPH) es considerado el principal factor etiológico del cáncer cervical, sin embargo han sido reconocidos múltiples co-factores tales como agentes microbianos, condiciones fisiológicas y genéticas del hospedador que determinarían el desarrollo de esta enfermedad. El objetivo principal del estudio fue evaluar las mutaciones en tres proto-oncogenes (k-ras, c-erbB-2 y c-myc), el polimorfismo en el codón 72 de gen oncosupresor p53 y del sistema HLA-DQA1 en el desarrollo de la carcinogénesis cervical, en función de la infección con el VPH, Virus del Herpes Simplex (VHS) y Chlamydia trachomatis. Se estudiaron 304 muestras cervicales clasificadas histológicamente en: 79 muestras normales (PapI/II), 36 lesiones condilomatosas, 79 lesiones intraepiteliales de bajo grado (LGSIL), 75 lesiones intraepiteliales de células escamosas de alto grado (HGSIL) y 35 carcinomas intraepitelilales de células escamosas (SCC). La detección/tipificación y carga viral del VPH se realizaron por PCR-LIS-SSCP y LS-PCR respectivamente. La detección de las infecciones por VHS y C. trachomatis se realizó por PCR específicas. Las mutaciones en el codón 12 de k-ras se detectaron por ARMS-PCR, mientras que los eventos de amplificación génica en c-erbB-2 y c-myc se analizaron por RG-PCR y LS-PCR. El polimorfismo Arg/Pro en el codón 72 de p53 se estudió por PCR alelo específica y las variantes alélicas del HLA-DQA1 se analizaron por la metodología de hibridación reversa. La prevalencia de la infección por VPH, VHS y C. trachomatis en el grupo control fue del 30%, 21% y 12% respectivamente, las cuales incrementaron significativamente según la severidad de la lesión. Los tipos virales más prevalentes del VPH fueron el tipo 16 (48%) y 6 (33%). Las infecciones con alta carga viral se encontraron particularmente asociadas a la presencia del genoma del VPH 16 y a los HGSIL/SCC. Se registro un incremento significativo en la frecuencia de mutaciones en el codón 12 de k-ras en el estadios histológicos HGSIL (21,3%), la cual se correlacionó con las infecciones con VPH de alto riesgo. Se encontraron diferencias significativas en la amplificación del gen c-erbB-2 en el estadío LGSIL (16,4%) en asociación con los tipos virales de bajo riesgo. Se detectó un incremento en la frecuencia de amplificación para c-myc en los estadios histológicos HGSIL/SCC (34-40%) en correlación con la presencia del genoma del VPH 16. No se observaron diferencias significativas entre las frecuencias genotípicas de p53 y los grupos histológicos, la infección por VPH y el resto de las variables estudiadas. El análisis del polimorfismo en el sistema HLA-DQA1 revelo un incremento significativo en la frecuencia alélica del DQA1*0101 en los LGSIL/condilomas, sugiriendo algún rol predisponente para este tipo de lesiones. La infección por VHS y C. trachomatis podrían ser consideradas como cofactores en el proceso de carcinogénesis cervical, por incrementar el riesgo de desarrollo del cáncer cervical y de las lesiones intraepiteliales de alto grado respectivamente. La activación de los proto-oncogenes estudiados sugeriría mecanismos alternativos a los conocidos por los cuales los tipos virales de alto riesgo carcinogénico podrían determinar la transformación celular.

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Open Access Articles Have a Greater Research Impact Than Articles Not Freely Available

Evidence Based Library and Information Practice ◽

10.18438/b8c88z ◽

2006 ◽

Vol 1 (3) ◽

pp. 57

Author(s):

Suzanne Pamela Lewis

Keyword(s):

Open Access ◽

Political Science ◽

Web Of Science ◽

Research Impact ◽

Sample Population ◽

Article Title ◽

Electronic Engineering ◽

Percentage Difference ◽

The Mean ◽

Leading Journals

A review of: Antelman, Kristin. “Do Open-Access Articles Have a Greater Research Impact?” College & Research Libraries 65.5 (Sep. 2004): 372-82. Objective – To ascertain whether open access articles have a greater research impact than articles not freely available, as measured by citations in the ISI Web of Science database. Design – Analysis of mean citation rates of a sample population of journal articles across four disciplines. Setting – Journal literature across the disciplines of philosophy, political science, mathematics, and electrical and electronic engineering. Subjects – A sample of 2,017 articles across the four disciplines published between 2001 and 2002 (for political science, mathematics, and electrical and electronic engineering) and between 1999 and 2000 (for philosophy). Methods – A systematic presample of articles for each of the disciplines was taken to calculate the necessary sample sizes. Based on this calculation, articles were sourced from ten leading journals in each discipline. The leading journals in political science, mathematics, and electrical and electronic engineering were defined by ISI’s Journal Citation Reports for 2002. The ten leading philosophy journals were selected using a combination of other methods. Once the sample population had been identified, each article title and the number of citations to each article (in the ISI Web of Science database) were recorded. Then the article title was searched in Google and if any freely available full text version was found, the article was classified as open access. The mean citation rate for open access and non-open access articles in each discipline was identified, and the percentage difference between the means was calculated. Main results – The four disciplines represented a range of open access uptake: 17% of articles in philosophy were open access, 29% in political science, 37% in electrical and electronic engineering, and 69% in mathematics. There was a significant difference in the mean citation rates for open access articles and non-open access articles in all four disciplines. The percentage difference in means was 45% in philosophy, 51% in electrical and electronic engineering, 86% in political science, and 91% in mathematics. Mathematics had the highest rate of open access availability of articles, but political science had the greatest difference in mean citation rates, suggesting there are other, discipline-specific factors apart from rate of open access uptake affecting research impact. Conclusion – The finding that, across these four disciplines, open access articles have a greater research impact than non-open access articles, is only one aspect of the complex changes that are presently taking place in scholarly publishing and communication. However, it is useful information for librarians formulating strategies for building institutional repositories, or exploring open access publishing with patrons or publishers.

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Applying generalizability theory to examine assessments of subjective cognitive complaints: whose reports should we rely on – participant versus informant?

International Psychogeriatrics ◽

10.1017/s1041610221000363 ◽

2021 ◽

pp. 1-11

Author(s):

Q. C. Truong ◽

C. Choo ◽

K. Numbers ◽

A. G. Merkin ◽

H. Brodaty ◽

...

Keyword(s):

Predominantly White ◽

Generalizability Theory ◽

The Elderly ◽

Community Dwelling ◽

Assessment Tools ◽

Sample Population ◽

Cognitive Complaints ◽

Longitudinal Measurement ◽

Measurement Design ◽

Subjective Cognitive Complaints

ABSTRACT Objectives: This study aimed to apply the generalizability theory (G-theory) to investigate dynamic and enduring patterns of subjective cognitive complaints (SCC), and reliability of two widely used SCC assessment tools. Design: G-theory was applied to assessment scales using longitudinal measurement design with five assessments spanning 10 years of follow-up. Setting: Community-dwelling older adults aged 70–90 years and their informants, living in Sydney, Australia, participated in the longitudinal Sydney Memory and Ageing Study. Participants: The sample included 232 participants aged 70 years and older, and 232 associated informants. Participants were predominantly White Europeans (97.8%). The sample of informants included 76 males (32.8%), 153 females (65.9%), and their age ranged from 27 to 86 years, with a mean age of 61.3 years (SD = 14.38). Measurements: The Memory Complaint Questionnaire (MAC-Q) and the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Results: The IQCODE demonstrated strong reliability in measuring enduring patterns of SCC with G = 0.86. Marginally acceptable reliability of the 6-item MAC-Q (G = 0.77–0.80) was optimized by removing one item resulting in G = 0.80–0.81. Most items of both assessments were measuring enduring SCC with exception of one dynamic MAC-Q item. The IQCODE significantly predicted global cognition scores and risk of dementia incident across all occasions, while MAC-Q scores were only significant predictors on some occasions. Conclusions: While both informants’ (IQCODE) and self-reported (MAC-Q) SCC scores were generalizable across sample population and occasions, self-reported (MAC-Q) scores may be less accurate in predicting cognitive ability and diagnosis of each individual.

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Fruit and Vegetable Intake and All-Cause Mortality in a Chinese Population: The China Health and Nutrition Survey

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18010342 ◽

2021 ◽

Vol 18 (1) ◽

pp. 342

Author(s):

Yuxuan Gu ◽

Yansu He ◽

Shahmir H. Ali ◽

Kaitlyn Harper ◽

Hengjin Dong ◽

...

Keyword(s):

Vegetable Intake ◽

Total Mortality ◽

Negative Association ◽

Mortality Data ◽

Sample Population ◽

Fruit And Vegetable ◽

Nutrition Survey ◽

Related Factors ◽

Health And Nutrition ◽

All Cause Mortality

This study was to investigate the association of long-term fruit and vegetable (FV) intake with all-cause mortality. We utilized data from the China Health and Nutrition Survey (CHNS), a prospective cohort study conducted in China. The sample population included 19,542 adult respondents with complete mortality data up to 31 December 2011. Cumulative FV intake was assessed by 3 day 24 h dietary recalls. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of all-cause mortality. Covariates included sociodemographic characteristics, lifestyle factors, health-related factors, and urban index. A total of 1409 deaths were observed during follow-up (median: 14 years). In the fully adjusted model, vegetable intake of the fourth quintile (327~408 g/day) had the greatest negative association with death compared to the lowest quintile (HR = 0.63, 95% CI: 0.53–0.76). Fruit intake of the fifth quintile (more than 126 g/day) had the highest negative association (HR = 0.24, 95% CI: 0.15–0.40) and increasing general FV intake were also negatively associated with all-cause mortality which demonstrated the greatest negative association in the amount of fourth quintile (HR = 0.59, 95% CI: 0.49–0.70) compared to the lowest quintile. To conclude, greater FV intake is associated with a reduced risk of total mortality for Chinese adults. High intake of fruit has a stronger negative association with mortality than differences in intake of vegetables. Our findings support recommendations to increase the intake of FV to promote overall longevity.

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