Resistance exercise training attenuates exercise-induced lipid peroxidation in the elderly

2002 ◽  
Vol 87 (4-5) ◽  
pp. 416-423 ◽  
Author(s):  
Kevin Vincent ◽  
Heather Vincent ◽  
Randy Braith ◽  
Shannon Lennon ◽  
David Lowenthal
2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Kishiko Ogawa ◽  
Kiyoshi Sanada ◽  
Shuichi Machida ◽  
Mitsuharu Okutsu ◽  
Katsuhiko Suzuki

Aging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) participated in 12 weeks of resistance exercise training. Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. Training reduced the circulating levels of CRP, SAA (P<.05), HSP70, IGF-I, and insulin (P<.01). The training-induced reductions in CRP and TNF-α were significantly (P<.01,P<.05) associated with increased muscle thickness (r=−0.61,r=−0.54), respectively. None of the results were significant after applying a Bonferroni correction. Resistance training may assist in maintaining or improving muscle volume and reducing low-grade inflammation.


Gerontology ◽  
2005 ◽  
Vol 51 (4) ◽  
pp. 253-265 ◽  
Author(s):  
Ivan Bautmans ◽  
Rose Njemini ◽  
Sabine Vasseur ◽  
Hans Chabert ◽  
Lisa Moens ◽  
...  

1996 ◽  
Vol 81 (5) ◽  
pp. 2095-2104 ◽  
Author(s):  
S. Nissen ◽  
R. Sharp ◽  
M. Ray ◽  
J. A. Rathmacher ◽  
D. Rice ◽  
...  

Nissen, S., R. Sharp, M. Ray, J. A. Rathmacher, D. Rice, J. C. Fuller, Jr., A. S. Connelly, and N. Abumrad. Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training. J. Appl. Physiol. 81(5): 2095–2104, 1996.—The effects of dietary supplementation with the leucine metabolite β-hydroxy-β-methylbutyrate (HMB) were studied in two experiments. In study 1, subjects ( n = 41) were randomized among three levels of HMB supplementation (0, 1.5 or 3.0 g HMB/day) and two protein levels (normal, 117 g/day, or high, 175 g/day) and weight lifted for 1.5 h 3 days/wk for 3 wk. In study 2, subjects ( n = 28) were fed either 0 or 3.0 g HMB/day and weight lifted for 2–3 h 6 days/wk for 7 wk. In study 1, HMB significantly decreased the exercise-induced rise in muscle proteolysis as measured by urine 3-methylhistidine during the first 2 wk of exercise (linear decrease, P < 0.04). Plasma creatine phosphokinase was also decreased with HMB supplementation ( week 3, linear decrease, P < 0.05). Weight lifted was increased by HMB supplementation when compared with the unsupplemented subjects during each week of the study (linear increase, P < 0.02). In study 2, fat-free mass was significantly increased in HMB-supplemented subjects compared with the unsupplemented group at 2 and 4–6 wk of the study ( P < 0.05). In conclusion, supplementation with either 1.5 or 3 g HMB/day can partly prevent exercise-induced proteolysis and/or muscle damage and result in larger gains in muscle function associated with resistance training.


2003 ◽  
Vol 3 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Itsuko Kitamura ◽  
Nobuo Takeshima ◽  
Mizuho Tokudome ◽  
Kunio Yamanouchi ◽  
Yoshiharu Oshida ◽  
...  

1993 ◽  
Vol 265 (2) ◽  
pp. E210-E214 ◽  
Author(s):  
K. E. Yarasheski ◽  
J. J. Zachwieja ◽  
D. M. Bier

Muscle mass and function are improved in the elderly during resistance exercise training. These improvements must result from alterations in the rates of muscle protein synthesis and breakdown. We determined the rate of quadriceps muscle protein synthesis using the in vivo rate of incorporation of intravenously infused [13C]leucine into mixed-muscle protein in both young (24 yr) and elderly (63-66 yr) men and women before and at the end of 2 wk of resistance exercise training. Before training, the fractional rate of muscle protein synthesis was lower in the elderly than in the young (0.030 +/- 0.003 vs. 0.049 +/- 0.004%/h; P = 0.004) but increased (P < 0.03) to a comparable rate of muscle protein synthesis in both young (0.075 +/- 0.009%/h) and elderly subjects (0.076 +/- 0.011%/h) after 2 wk of exercise. In the elderly, muscle mass, 24-h urinary 3-methylhistidine and creatinine excretion, and whole body protein breakdown rate determined during the [13C]leucine infusion were not changed after 2 wk of exercise. These findings demonstrate that, during the initial phase of a resistance exercise training program, a marked increase in quadriceps muscle protein synthesis rate occurs in elderly and young adults without an increase in the rate of whole body protein breakdown. In the elderly, this was not accompanied by an increase in urinary 3-methylhistidine excretion, an index of myofibrillar protein breakdown.


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