scholarly journals Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Kishiko Ogawa ◽  
Kiyoshi Sanada ◽  
Shuichi Machida ◽  
Mitsuharu Okutsu ◽  
Katsuhiko Suzuki
Keyword(s):  
Exercise Training ◽  
Resistance Exercise ◽  
Elderly Women ◽  
Muscle Thickness ◽  
The Elderly ◽  
Low Grade ◽  
Resistance Exercise Training ◽  
Tnf Α ◽  
Low Grade Inflammation ◽  
Circulating Levels

Aging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) participated in 12 weeks of resistance exercise training. Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. Training reduced the circulating levels of CRP, SAA (P<.05), HSP70, IGF-I, and insulin (P<.01). The training-induced reductions in CRP and TNF-α were significantly (P<.01,P<.05) associated with increased muscle thickness (r=−0.61,r=−0.54), respectively. None of the results were significant after applying a Bonferroni correction. Resistance training may assist in maintaining or improving muscle volume and reducing low-grade inflammation.

Resistance exercise training attenuates exercise-induced lipid peroxidation in the elderly

2002 ◽  
Vol 87 (4-5) ◽  
pp. 416-423 ◽  
Author(s):  
Kevin Vincent ◽  
Heather Vincent ◽  
Randy Braith ◽  
Shannon Lennon ◽  
David Lowenthal
Keyword(s):  
Lipid Peroxidation ◽  
Exercise Training ◽  
Resistance Exercise ◽  
The Elderly ◽  
Resistance Exercise Training ◽  
Exercise Induced

scholarly journals The Role of Exercise Training on Low-Grade Systemic Inflammation in Adults with Overweight and Obesity: A Systematic Review

2021 ◽  
Vol 18 (24) ◽  
pp. 13258
Author(s):  
Paola Gonzalo-Encabo ◽  
Gonzalo Maldonado ◽  
David Valadés ◽  
Carmen Ferragut ◽  
Alberto Pérez-López
Keyword(s):  
Exercise Training ◽  
Systemic Inflammation ◽  
Fat Mass ◽  
Overweight And Obesity ◽  
Concurrent Training ◽  
Low Grade ◽  
Mass Reduction ◽  
Tnf Α ◽  
Exercise Induced ◽  
Low Grade Inflammation

Low-grade systemic inflammation leads to critical alterations of several tissues and organs that can promote the appearance of non-communicable diseases, a risk that is increased in adults with obesity. Exercise training may counteract low-grade systemic inflammation, but there is a lack of consensus on how cytokines are modulated by training in adults with obesity. This study aimed of examining the effects of exercise training on circulating pro- and anti-inflammatory cytokines in adults with overweight and obesity, and whether exercise-induced fat mass reduction could mediate that effect. The search was conducted on Medline (Pubmed), SPORTDiscus and Web of Science databases from January 1998 to August 2021, using keywords pertaining to inflammation, exercise, and obesity. A total of 27 studies were selected, in which the circulating concentration levels of cytokines were analyzed. Endurance training (ET) decreased circulating CRP, IL-6 and TNF-α levels. TNF-α was reduced after resistance and concurrent training (CT), while IL-10 increased after resistance training (RT). Changes in IL-10 and CRP coincided with fat mass reduction, while decreased TNF-α levels were concomitant with changes in IL-6 and IL-10. Exercise training may reduce systemic low-grade inflammation profile in adults with overweight and obesity.

Biochemical Changes in Response to Intensive Resistance Exercise Training in the Elderly

Gerontology ◽  
2005 ◽  
Vol 51 (4) ◽  
pp. 253-265 ◽  
Author(s):  
Ivan Bautmans ◽  
Rose Njemini ◽  
Sabine Vasseur ◽  
Hans Chabert ◽  
Lisa Moens ◽  
...  
Keyword(s):  
Exercise Training ◽  
Resistance Exercise ◽  
The Elderly ◽  
Biochemical Changes ◽  
Resistance Exercise Training

scholarly journals Combined Exercise Training Performed by Elderly Women Reduces Redox Indexes and Proinflammatory Cytokines Related to Atherogenesis

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
André L. L. Bachi ◽  
Marcelo P. Barros ◽  
Rodolfo P. Vieira ◽  
Gislene A. Rocha ◽  
Paula B. M. de Andrade ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Proinflammatory Cytokines ◽  
Elderly Women ◽  
Plasma Lipid ◽  
Hdl Cholesterol ◽  
Moderate Intensity ◽  
Trained Group ◽  
Resistance Exercise Training

Cardiovascular benefits for the general population of combined aerobic-resistance exercise training are well-known, but the impact of this exercise training modality on the plasma lipid, inflammatory, and antioxidant status in elderly women that are exposed to a great risk of developing ischemic cardio- and cerebrovascular diseases has not been well investigated. So, we aimed to evaluate the plasma lipids, oxidative stress, and inflammatory cytokines in 27 elderly women (TRAINED group, 69.1±8.1 yrs) that were performing moderate intensity combined aerobic-resistance exercise training (3 times/week for at least 18 months) and in 27 sedentary elderly women (SED group, 72.0±6.4 yrs), not submitted to exercise training for at least 5 yrs. Our results showed that BMI was lower in the TRAINED group than in the SED group (25.1±3.2 vs. 28.7±5.1, p<0.05). The TRAINED group had lower glycemia (92±3 vs. 118±12, p<0.05), glycated hemoglobin (5.9±0.1 vs. 6.4±0.2, p<0.05), and triglycerides (98 (75-122) vs. 139 (109-214), p<0.01); equal total cholesterol (199 (175-230) vs. 194 (165-220)), LDL-cholesterol (108 (83-133) vs. 109 (98-136)), and non-HDL-cholesterol (54 (30-74) vs. 62 (26-80)); and also higher HDL-cholesterol (64 (52-77) vs. 52 (44-63), p<0.01) and LDL-C/oxLDL ratio (13378±2570 vs. 11639±3113, p<0.05) compared to the SED group. Proinflammatory cytokines as IL-1β (11.31±2.4 vs. 28.01±4.7, p<0.05), IL-6 (26.25±7.4 vs. 49.41±17.8, p<0.05), and TNF-α (25.72±2.8 vs. 51.73±4.2, p<0.05) were lower in the TRAINED group than in the SED group. The TRAINED group had lower total peroxides (26.3±7.4 vs. 49.0±17.8, p<0.05) and oxidized LDL (1551±50.33 vs. 1773±74, p<0.02) and higher total antioxidant capacity (26.25±7.4 vs. 49.41±17.8, p<0.001) compared to the SED group. In conclusion, in TRAINED women, BMI was lower, plasma lipid profile was better, plasma oxidative stress was diminished, and there was less expression of proinflammatory interleukins than in SED, suggesting that combined aerobic-resistance exercise training may promote the protection against the complications of ischemic cardio- and cerebrovascular disease in elderly women.

scholarly journals CYTOKINES AND BRAIN-DERIVED NEUROTROPHIC FACTOR IN CONTEXT OF COGNITIVE IMPAIRMENT IN THE ELDERLY

2019 ◽  
Vol 19 (1S) ◽  
pp. 18-19
Author(s):  
Yu Yu Filippova ◽  
M E Kholodilina ◽  
A L Burmistrova
Keyword(s):  
Cognitive Impairment ◽  
Vascular Dementia ◽  
Statistical Significance ◽  
The Elderly ◽  
Low Grade ◽  
Serum Concentrations ◽  
Repair Mechanism ◽  
Tnf Α ◽  
The Central Nervous System ◽  
Low Grade Inflammation

The aim is to assess the levels of certain cytokines IL-6, TNF-α, IL-1β и IL-10, and BDNF in the blood plasma of the elderly, depending on degree of cognitive impairment. 65 elderly with (vascular dementia) or without cognitive impairment were enrolled in the study. The level of cytokines and BDNF were measured in plasma by ELISA. It was found that, regardless of the degree of cognitive impairment, the condition of systemic chronic low-grade inflammation is characteristic of the elderly. Against this background, plasma levels of BDNF were increased in elderly with vascular dementia, reaching statistical significance compared with healthy individuals. Such changes in the level of BDNF may reflect a compensatory repair mechanism in neurodegeneration or be associated with a defective axonal transport or utilization of BDNF in the central nervous system paralleled by increased serum concentrations.

Exercise training, inflammatory cytokines, and other markers of low-grade inflammation in breast cancer survivors: A systematic review and meta-analysis.

2014 ◽  
Vol 32 (26_suppl) ◽  
pp. 121-121 ◽  
Author(s):  
Jose F Meneses-Echavez ◽  
Robinson Ramirez-Velez ◽  
Emilio Gonzalez-Jimenez ◽  
Jacqueline Schmidt Rio-Valle ◽  
Maria Jose Sanchez Perez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Exercise Training ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Serum Levels ◽  
Low Grade ◽  
Exercise Interventions ◽  
Randomized Controlled ◽  
Tnf Α ◽  
Low Grade Inflammation

121 Background: Low-grade inflammation, characterized by high cytokine activity, plays a crucial role in tumorigenesis. Further, cytokines and other inflammatory biomarkers are closely implicated in tumor growth, angiogenesis, and metastasis. This metaanalysis of randomized controlled trials estimates the effects of exercise training in the control of the serum levels of cytokines and other inflammatory markers in breast cancer survivors. Methods: PRISMA statement and the Cochrane Handbook were followed. We searched MEDLINE, CENTRAL, EMBASE, Scopus and DARE database to retrieve randomized controlled trials published between 1980- March 2014 providing effect estimates of exercise interventions in the serum levels of cytokines, such as interleukin (IL) -2, IL-6, IL-8, tumoral necrosis factor alpha (TNF-α) and C-reactive protein (CRP) in breast cancer survivors. An Inverse of variance (IV) fixed-effects model was conducted in absence of heterogeneity (I2<50%); otherwise a random-effects model was selected. Mean Differences (MD) were calculated to estimate differences between groups (p<0.05 with 95% Confidence interval). Heterogeneity was measured with the Chi2 test (p<0.10) and I2 statistics. Results: A total of 15 studies were included (n=1,447; mean age= 51.6 years old). Exercise interventions resulted in positive effects for CRP (MD= 0.37, 95%CI, 0.04 to 0.71; p= 0.03; I2=15%), IL-2 (MD= -6.04, 85%CI, -11.41 to -0.67; p=0.03; I2=0%), IL-10 (-22.90, 95%CI, -41.27 to -4.53; p=0.001, I2=0%) and waist circumference as indicator of body composition (MD= -1.12, 95%CI, -2.06 to -0.18; p=0.02; I2=45%). Non-significant differences were observed for IL-6 and TNF-α. There was no evidence of publication bias. Conclusions: These findings suggest that exercise training improves the systemic pro-inflammatory profile in breast cancer survivors and consequently the immunological responses and the carcinogenic processes related to tumoral environment. The effects observed for IL-10 provide a novel focus of evidence for the role of exercise as an effective anti-inflammatory intervention in cancer survivors.

Effects of aerobic and resistance exercise training on insulin action in the elderly

2003 ◽  
Vol 3 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Itsuko Kitamura ◽  
Nobuo Takeshima ◽  
Mizuho Tokudome ◽  
Kunio Yamanouchi ◽  
Yoshiharu Oshida ◽  
...  
Keyword(s):  
Exercise Training ◽  
Resistance Exercise ◽  
Insulin Action ◽  
The Elderly ◽  
Resistance Exercise Training
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