scholarly journals Green drugs in the fight against Anisakis simplex—larvicidal activity and acetylcholinesterase inhibition of Origanum compactum essential oil

2018 ◽  
Vol 117 (3) ◽  
pp. 861-867 ◽  
Author(s):  
Víctor López ◽  
María Cascella ◽  
Giovanni Benelli ◽  
Filippo Maggi ◽  
Carlota Gómez-Rincón
Molecules ◽  
2019 ◽  
Vol 24 (14) ◽  
pp. 2563 ◽  
Author(s):  
Víctor López ◽  
Roman Pavela ◽  
Carlota Gómez-Rincón ◽  
Francisco Les ◽  
Fabrizio Bartolucci ◽  
...  

Developing effective and eco-friendly antiparasitic drugs and insecticides is an issue of high importance nowadays. In this study, we evaluated the anthelminthic and insecticidal potential of the leaf essential oil obtained from Origanum syriacum against the L3 larvae of the parasitic nematode Anisakis simplex and larvae and adults of the mosquito Culex quinquefasciatus. Tests on A. simplex were performed by standard larvicidal and penetration assays, while mosquito toxicity was assessed relying on larvicidal, tarsal contact, and fumigation tests. To shed light on the possible mode of action, we analyzed the oil impact as acetylcholinesterase (AChE) inhibitor. This oil was particularly active on L3 larvae of A. simplex, showing a LC50 of 0.087 and 0.067 mg mL−1 after 24 and 48 h treatment, respectively. O. syriacum essential oil was highly effective on both larvae and adults of C. quinquefasciatus, showing LC50 values of 32.4 mg L−1 and 28.1 µg cm−2, respectively. Its main constituent, carvacrol, achieved larvicidal LC50(90) of 29.5 and 39.2 mg L−1, while contact toxicity assays on adults had an LC50(90) of 25.5 and 35.8 µg cm−2, respectively. In fumigation assays, the LC50 was 12.1 µL L−1 after 1 h and decreased to 1.3 µL L−1 in 24 h of exposure. Similarly, the fumigation LC50 of carvacrol was 8.2 µL L−1 after 1 h of exposure, strongly decreasing to 0.8 µL L−1 after 24 h of exposure. These results support the folk usage of Lebanese oregano as an antiparasitic agent, providing new insights about its utilization for developing new effective and eco-friendly nematocidal and insecticidal products.


Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1303 ◽  
Author(s):  
Do N. Dai ◽  
Nguyen T. Chung ◽  
Le T. Huong ◽  
Nguyen H. Hung ◽  
Dao T.M. Chau ◽  
...  

Members of the genus Cinnamomum (Lauraceae) have aromatic volatiles in their leaves and bark and some species are commercially important herbs and spices. In this work, the essential oils from five species of Cinnamomum (C. damhaensis, C. longipetiolatum, C. ovatum, C. polyadelphum and C. tonkinense) growing wild in north central Vietnam were obtained by hydrodistillation, analyzed by gas chromatography and screened for antimicrobial and mosquito larvicidal activity. The leaf essential oil of C. tonkinense, rich in β-phellandrene (23.1%) and linalool (32.2%), showed excellent antimicrobial activity (MIC of 32 μg/mL against Enterococcus faecalis and Candida albicans) and larvicidal activity (24 h LC50 of 17.4 μg/mL on Aedes aegypti and 14.1 μg/mL against Culex quinquefasciatus). Cinnamomum polyadelphum leaf essential oil also showed notable antimicrobial activity against Gram-positive bacteria and mosquito larvicidal activity, attributable to relatively high concentrations of neral (11.7%) and geranial (16.6%). Thus, members of the genus Cinnamomum from Vietnam have shown promise as antimicrobial agents and as potential vector control agents for mosquitoes.


2011 ◽  
Vol 21 (1) ◽  
pp. 0-0 ◽  
Author(s):  
Evelyn Ivana T. Damasceno ◽  
Joyce Kelly R. Silva ◽  
Eloisa Helena A. Andrade ◽  
Pergentino José C. Sousa ◽  
José Guilherme S. Maia

2017 ◽  
Vol 54 (3) ◽  
pp. 670-676 ◽  
Author(s):  
Agustín Alvarez Costa ◽  
Cecilia V. Naspi ◽  
Alejandro Lucia ◽  
Héctor M. Masuh

2018 ◽  
Vol 30 (5) ◽  
pp. 379-387 ◽  
Author(s):  
Carla Maria Mariano Fernandez ◽  
Maurício Ferreira da Rosa ◽  
Ana Claudia Aparecida Mariano Fernandez ◽  
Fabiana Brusco Lorenzetti ◽  
Keila Fernanda Raimundo ◽  
...  

2020 ◽  
Vol 69 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Le T. Huong ◽  
Trinh T. Huong ◽  
Nguyen T.T. Huong ◽  
Nguyen H. Hung ◽  
Pham T.T. Dat ◽  
...  

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