Dental pulp stem cell transplantation ameliorates motor function and prevents cerebellar atrophy in rat model of cerebellar ataxia

2019 ◽  
Vol 376 (2) ◽  
pp. 179-187 ◽  
Author(s):  
Abbas Aliaghaei ◽  
Mahdi Eskandarian Boroujeni ◽  
Houssein Ahmadi ◽  
Amir-Hossein Bayat ◽  
Mostafa Rezaei Tavirani ◽  
...  
Cytotherapy ◽  
2017 ◽  
Vol 19 (10) ◽  
pp. 1208-1224 ◽  
Author(s):  
Indrani Datta ◽  
Naini Bhadri ◽  
Pradnya Shahani ◽  
Debanjana Majumdar ◽  
Sowmithra Sowmithra ◽  
...  

Author(s):  
Babyla Geraldes Monteiro ◽  
Renata Ruoco Loureiro ◽  
Priscila Cardoso Cristovam ◽  
Joyce Luciana Covre ◽  
José Álvaro Pereira Gomes ◽  
...  

2021 ◽  
Vol 22 (9) ◽  
pp. 4357
Author(s):  
Sahng G. Kim

Despite the recent explosion of investigations on dental pulp regeneration using various tissue engineering strategies, the translation of the findings from such studies into therapeutic applications has not been properly achieved. The purpose of this scoping review was to systematically review the efficacy of mesenchymal stem cell transplantation for dental pulp regeneration. A literature search was conducted using five electronic databases from their inception to January 2021 and supplemented by hand searches. A total of 17 studies, including two clinical trials and 15 animal studies using orthotopic pulp regeneration models, were included for the review. The risk of bias for the individual studies was assessed. This scoping review demonstrated that the regeneration of vascularized pulp-like tissue was achieved using the stem cell transplantation strategy in animal models. Autologous cell transplantation in two clinical studies also successfully regenerated vascularized vital tissue. Dental pulp stem cell subpopulations, such as mobilized dental pulp stem cells, injectable scaffolds such as atelocollagen, and a granulocyte-colony forming factor, were the most commonly used for pulp regeneration. The overall risk of bias was unclear for animal studies and was moderate or judged to raise some concerns for clinical studies. More high-quality clinical studies are needed to further determine the safety and efficacy of the stem cell transplantation strategy for dental pulp regeneration.


2008 ◽  
Vol 37 (3) ◽  
pp. 454-470 ◽  
Author(s):  
Kadiombo Bantubungi ◽  
David Blum ◽  
Laetitia Cuvelier ◽  
Sabine Wislet-Gendebien ◽  
Bernard Rogister ◽  
...  

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