Prognostic Prediction of Dysphagia by Analyzing the Corticobulbar Tract in the Early Stage of Intracerebral Hemorrhage

AbstractThe hemorrhagic and the ischemic types of stroke have similar symptoms in the early stage, but their treatments are completely different. The timely and effective discrimination of the two types of stroke can considerable improve the patients' prognosis. In this paper, a 16-channel and noncontact microwave-based stroke detection system was proposed and demonstrated for the potential differentiation of the hemorrhagic and the ischemic stroke. In animal experiments, 10 rabbits were divided into two groups. One group consisted of five cerebral hemorrhage models, and the other group consisted of five cerebral ischemia models. The two groups were monitored by the system to obtain the Euclidean distance transform value of microwave scattering parameters caused by pathological changes in the brain. The support vector machine was used to identify the type and the severity of the stroke. Based on the experiment, a discrimination accuracy of 96% between hemorrhage and ischemia stroke was achieved. Furthermore, the potential of monitoring the progress of intracerebral hemorrhage or ischemia was evaluated. The discrimination of different degrees of intracerebral hemorrhage achieved 86.7% accuracy, and the discrimination of different severities of ischemia achieved 94% accuracy. Compared with that with multiple channels, the discrimination accuracy of the stroke severity with a single channel was only 50% for the intracerebral hemorrhage and ischemia stroke. The study showed that the microwave-based stroke detection system can effectively distinguish between the cerebral hemorrhage and the cerebral ischemia models. This system is very promising for the prehospital identification of the stroke type due to its low cost, noninvasiveness, and ease of operation.

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Early-stage minimally invasive procedures decrease perihematomal endothelin-1 levels and improve neurological functioning in a rabbit model of intracerebral hemorrhage

Neurological Research ◽

10.1179/1743132814y.0000000446 ◽

2014 ◽

Vol 37 (4) ◽

pp. 320-327 ◽

Cited By ~ 2

Author(s):

Likun Wang ◽

Fan Wang ◽

Guofeng Wu ◽

Jing Shi

Keyword(s):

Minimally Invasive ◽

Intracerebral Hemorrhage ◽

Early Stage ◽

Rabbit Model ◽

Minimally Invasive Procedures ◽

Invasive Procedures ◽

Endothelin 1 ◽

Neurological Functioning

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A Nomogram Based on Radiomics with Mammography Texture Analysis for the Prognostic Prediction in Patients with Triple-Negative Breast Cancer

Contrast Media & Molecular Imaging ◽

10.1155/2020/5418364 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Xian Jiang ◽

Xiuhe Zou ◽

Jing Sun ◽

Aiping Zheng ◽

Chao Su

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Early Stage ◽

Disease Free Survival ◽

Textural Features ◽

Lasso Regression ◽

Clinical Model ◽

Pn Stage ◽

Prognostic Prediction

Objectives. To develop and validate a radiomics-based nomogram with texture features from mammography for the prognostic prediction in patients with early-stage triple-negative breast cancer (TNBC). Methods. The study included 200 consecutive patients with TNBC (training cohort: n = 133, validation cohort: n = 67). A total of 136 mammography-derived textural features were extracted, and LASSO (least absolute shrinkage and selection operator) was applied to select features for building the radiomics score (Rad-score). After univariate and multivariate logistic regression, a radiomics-based nomogram was constructed with independent prognostic factors. The discrimination and calibration power were assessed, and further the clinical applicability of the nomograms was evaluated. Results. Among the 136 mammography-derived textural features, fourteen were used to build the Rad-score after LASSO regression. A radiomics nomogram that incorporates Rad-score and pN stage was constructed. This nomogram achieved a C-index of 0.873 (95% CI: 0.758–0.989) for predicting iDFS (invasive disease-free survival), which outperformed the clinical model. Moreover, it is feasible to stratify patients into high-risk and low-risk groups based on the optimal cut-off point of Rad-score. The validations of the nomogram confirmed favorable discrimination and considerable predictive efficiency. Conclusions. The radiomics nomogram that incorporates Rad-score and pN stage exhibited favorable performance in the prediction of iDFS in patients with early-stage TNBCs.

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Naples Prognostic Score as a novel prognostic prediction tool in video-assisted thoracoscopic surgery for early-stage lung cancer: a propensity score matching study

Surgical Endoscopy ◽

10.1007/s00464-020-07851-7 ◽

2020 ◽

Author(s):

Shuangjiang Li ◽

Hongyu Wang ◽

Zhang Yang ◽

Liang Zhao ◽

Wenyu Lv ◽

...

Keyword(s):

Lung Cancer ◽

Propensity Score ◽

Early Stage ◽

Thoracoscopic Surgery ◽

Prognostic Score ◽

Prediction Tool ◽

Early Stage Lung Cancer ◽

Prognostic Prediction ◽

Video Assisted Thoracoscopic Surgery ◽

Stage Lung Cancer

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The Effect of Mannitol in the Early Stage of Supratentorial Hypertensive Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

World Neurosurgery ◽

10.1016/j.wneu.2018.11.249 ◽

2019 ◽

Vol 124 ◽

pp. 386-396 ◽

Cited By ~ 1

Author(s):

Shuwen Sun ◽

Yuping Li ◽

Hengzhu Zhang ◽

Xiaodong Wang ◽

Lei She ◽

...

Keyword(s):

Systematic Review ◽

Intracerebral Hemorrhage ◽

Early Stage ◽

Meta Analysis ◽

Hypertensive Intracerebral Hemorrhage

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Septic Embolic Stroke Followed by Hemorrhage and Brain Abscess in a Patient with Systemic Infections: A Case Report and Literature Review

Case Reports in Radiology ◽

10.1155/2018/4602352 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Jama A. Mohamud ◽

Jingtao Wu ◽

Ye Jing ◽

Yu Wang

Keyword(s):

Intracerebral Hemorrhage ◽

Brain Abscess ◽

Early Stage ◽

Systemic Infection ◽

Occipital Lobe ◽

Neurological Status ◽

Radiographic Findings ◽

Brain Ct Scan ◽

The Right ◽

Systemic Infections

We report a case of 50-year-old man with a severe acute ischemic stroke followed by intracerebral hemorrhage and brain abscess due to systemic infection. His initial intracranial radiographic findings were normal but three days later MRI scan of the brain revealed well-defined rounded cystic lesion on the T2-weighted and T1-weighted images in the right basal ganglia; the lesion presented an area of diffusion restriction on DWI; lately the lesion was confirmed to be an early stage of cerebral abscess. A week later the patient was noted to have worsening neurological status and left extremity weakness, and emergency brain CT scan revealed massive intracerebral hemorrhage in the right occipital lobe; he underwent intracranial hematoma evacuation surgery. The hematoma was removed successfully, and the systemic infections were treated with antibiotics.

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Motor outcome according to diffusion tensor tractography findings in the early stage of intracerebral hemorrhage

Neuroscience Letters ◽

10.1016/j.neulet.2007.04.052 ◽

2007 ◽

Vol 421 (2) ◽

pp. 142-146 ◽

Cited By ~ 63

Author(s):

Sang-Hyun Cho ◽

Seong Ho Kim ◽

Byung Yun Choi ◽

Soo Ho Cho ◽

Jae Hoon Kang ◽

...

Keyword(s):

Intracerebral Hemorrhage ◽

Diffusion Tensor ◽

Early Stage ◽

Diffusion Tensor Tractography ◽

Motor Outcome

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High CSF thrombin concentration and activity is associated with an unfavorable outcome in patients with intracerebral hemorrhage

PLoS ONE ◽

10.1371/journal.pone.0241565 ◽

2020 ◽

Vol 15 (11) ◽

pp. e0241565

Author(s):

Harald Krenzlin ◽

Christina Frenz ◽

Jan Schmitt ◽

Julia Masomi-Bornwasser ◽

Dominik Wesp ◽

...

Keyword(s):

Intracerebral Hemorrhage ◽

Neurological Outcome ◽

Neuronal Damage ◽

Early Stage ◽

Demographic Data ◽

Clinical Status ◽

Oxidative Stress Marker ◽

Csf Levels ◽

Discharge From Hospital ◽

The Impact

Background The cerebral thrombin system is activated in the early stage after intracerebral hemorrhage (ICH). Expression of thrombin leads to concentration dependent secondary neuronal damage and detrimental neurological outcome. In this study we aimed to investigate the impact of thrombin concentration and activity in the cerebrospinal fluid (CSF) of patients with ICH on clinical outcome. Methods Patients presenting with space-occupying lobar supratentorial hemorrhage requiring extra-ventricular drainage (EVD) were included in our study. The CSF levels of thrombin, its precursor prothrombin and the Thrombin-Antithrombin complex (TAT) were measured using enzyme linked immune sorbent assays (ELISA). The oxidative stress marker Superoxide dismutase (SOD) was assessed in CSF. Initial clot size and intraventricular hemorrhage (IVH) volume was calculated based on by computerized tomography (CT) upon admission to our hospital. Demographic data, clinical status at admission and neurological outcome were assessed using the modified Rankin Scale (mRS) at 6-weeks and 6-month after ICH. Results Twenty-two consecutive patients (9 females, 11 males) with supratentorial hemorrhage were included in this study. CSF concentrations of prothrombin (p < 0.005), thrombin (p = 0.005) and TAT (p = 0.046) were statistical significantly different in patients with ICH compared to non-hemorrhagic CSF samples. CSF concentrations of thrombin 24h after ICH correlated with the mRS index after 6 weeks (r2 = 0.73; < 0.005) and 6 months (r2 = 0.63; < 0.005) after discharge from hospital. Thrombin activity, measured via TAT as surrogate parameter of coagulation, likewise correlated with the mRS at 6 weeks (r2 = 0.54; < 0.01) and 6 months (r2 = 0.66; < 0.04). High thrombin concentrations coincide with higher SOD levels 24h after ICH (p = 0.01). Conclusion In this study we found that initial thrombin concentration and activity in CSF of ICH patients did not correlate with ICH and IVH volume but are associated with a poorer functional neurological outcome. These findings support mounting evidence of the role of thrombin as a contributor to secondary injury formation after ICH.

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