Insulin-Like Growth Factor-1 (IGF-1) and Reduced Tongue Pressure in Relation to Atherosclerosis Among Community-Dwelling Elderly Japanese Men: A Cross-Sectional Study

Dysphagia ◽  
2020 ◽  
Vol 35 (6) ◽  
pp. 948-954
Author(s):  
Yuji Shimizu ◽  
Hirotomo Yamanashi ◽  
Yuko Noguchi ◽  
Jun Koyamatsu ◽  
Miho Higashi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Tongue Pressure ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Cross Sectional ◽  
Japanese Men ◽  
Elderly Japanese

Levels of the small insulin-like growth factor-binding protein are strongly related to those of insulin in prepubertal and pubertal children but only weakly so after puberty

1989 ◽  
Vol 121 (2) ◽  
pp. 383-387 ◽  
Author(s):  
J. M. P. Holly ◽  
C. P. Smith ◽  
D. B. Dunger ◽  
J. A. Edge ◽  
R. A. Biddlecombe ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Pubertal Development ◽  
Circadian Variation ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Normal Children ◽  
Cross Sectional ◽  
The Relationship

ABSTRACT We have looked at the relationship between fasting levels of insulin and a small insulin-like growth factor (IGF)-binding protein (IBP-1) in a cross-sectional study of 116 normal subjects aged 5–48 years. The relationship between IBP-1 and insulin was also examined within individual normal children in over-night profiles of IBP-1 and insulin obtained from two children at each stage of puberty (Tanner stages 1–5). In the cross-sectional study high levels of IBP-1 were found in early childhood and these fell throughout puberty as fasting levels of insulin rose. Multiple regression analysis revealed that both these changes were predominantly due to pubertal development rather than to age. After the age of 16 IBP-1 levels remained low despite fasting insulin levels returning to prepubertal levels. A strong negative correlation was obtained between IBP-1 and insulin in children of 5–16 years (r = −0·63; n = 60; P <0·001), no such relationship being found after the age of 16. In the second study, IBP-1 underwent a marked circadian variation in all cases and an inverse correlation with insulin, measured at the same time, was obtained at pubertal stages 1 to 4, but not at stage 5 (pooled data stages 1–4, r = −0·69; n = 53; P <0·001). We have demonstrated that a potential inhibitor of IGF-activity is inversely related to insulin throughout the period of active GH-related growth and that this relationship weakens after puberty. Journal of Endocrinology (1989) 121, 383–387

scholarly journals Physical performance in relation to preserved ratio impaired spirometry: a cross-sectional study of community-dwelling older Japanese adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kunihiko Anami ◽  
Shin Murata ◽  
Hideki Nakano ◽  
Koji Nonaka ◽  
Hiroaki Iwase ◽  
...  
Keyword(s):  
Older Adults ◽  
Demographic Data ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Normal Lung ◽  
Sectional Study ◽  
Cross Sectional ◽  
Physical Functions ◽  
Elderly Japanese ◽  
Community Dwelling Older Adults

AbstractPreserved ratio impaired spirometry (PRISm) is associated with an increased mortality rate; however, its characteristics have not been clearly identified in Japan. This cross-sectional study of community-dwelling older adults compared physical function between people with PRISm and those with no respiratory issues, from 2014 to 2019. We collected demographic data through interviews and measured respiratory and physical functions. We included 668 older adults (male, 23.5%; mean age, 72.8 ± 5.6 years); the prevalence of PRISm was 12%, while the prevalence of obstruction was 6.9%. Propensity score matching was used to identify control subjects with normal spirometry (n = 80) while minimizing the effects of confounders during comparisons with the PRISm population (n = 80). Compared with community-dwelling older adults with normal lung capacity, older adults with PRISm had a lower forced vital capacity (%FVC; 68.7 ± 9.1% vs. 92.5 ± 12.7%, p < 0.001), lower core muscle endurance (sit-up test: 6.7 ± 5.8 vs. 8.7 ± 6.0, p = 0.032), and a longer one-leg stance duration (52.4 ± 41.1 s vs. 36.4 ± 34.1 s, p = 0.008). In multivariable logistic regression, %FVC and increased one-leg stance were independent predictors of PRISm status. The prevalence of PRISm among community-dwelling elderly Japanese exceeds that of obstructive lung disease and is associated with reduced %FVC and better performance on balance testing.

Somatomedins in Adolescence: A Cross-Sectional Study of the Effect of Puberty on Plasma Insulin-Like Growth Factor I and II Levels*

1983 ◽  
Vol 57 (2) ◽  
pp. 268-271 ◽  
Author(s):  
ALICE M. LUNA ◽  
DARRELL M. WILSON ◽  
CHARLES J. WIBBELSMAN ◽  
RICHARD C. BROWN ◽  
RAYMOND J. NAGASHIMA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Plasma Insulin ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factor I ◽  
Growth Factor I

Age, Sex, and Smoking Are Predictors of Circulating Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor–Binding Protein 3

1999 ◽  
Vol 17 (3) ◽  
pp. 813-813 ◽  
Author(s):  
Virginia G. Kaklamani ◽  
Athena Linos ◽  
Evangelia Kaklamani ◽  
Ioanna Markaki ◽  
Christos Mantzoros
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Coffee Drinking ◽  
History Of

PURPOSE: Insulin-like growth factor (IGF-1) and its major binding protein (IGF-BP3) have recently been implicated in the pathogenesis of several malignancies. However, anthropometric and lifestyle predictors of these hormones have not been elucidated. Here we report the results of a cross-sectional study. SUBJECTS AND METHODS: This cross-sectional study examines the relationship of a series of epidemiologic parameters (age, sex, height, body mass index, smoking, alcohol consumption, and coffee drinking) with IGF-1 and IGF-BP3 in a sample of 130 healthy adults. RESULTS: We observed that serum levels of IGF-1 are higher, whereas levels of IGF-BP3 are lower, in men than in women. In addition, serum levels of IGF-1 are independently and negatively associated with age and positively associated with pack-year history of smoking. Finally, serum levels of IGF-BP3 are independently and negatively associated with the number of cigarettes smoked per day or pack-year history of smoking. CONCLUSION: Age, sex, and smoking are independent predictors of IGF-1 and/or IGF-BP3. The influence of these epidemiologic variables on the pathogenesis of disease states associated with IGF-1 and IGF-BP3 warrants further exploration.

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