Effects of body mass index, mesenteric and abdominal subcutaneous adipose tissue on the spinopelvic parameters

2015 ◽  
Vol 127 (23-24) ◽  
pp. 935-941 ◽  
Author(s):  
Emine Uysal ◽  
Yahya Paksoy ◽  
Mustafa Koplay ◽  
Alaaddin Nayman ◽  
Serter Gumus
Keyword(s):  
Body Mass Index ◽  
Adipose Tissue ◽  
Body Mass ◽  
Subcutaneous Adipose Tissue ◽  
Spinopelvic Parameters ◽  
Subcutaneous Adipose

scholarly journals Multifaceted genome-wide study identifies novel regulatory loci for body mass index in Indians

2019 ◽  
Author(s):  
Anil K Giri ◽  
Gauri Prasad ◽  
Khushdeep Bandesh ◽  
Vaisak Parekatt ◽  
Anubha Mahajan ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Adipose Tissue ◽  
Body Mass ◽  
Subcutaneous Adipose Tissue ◽  
Regulatory Elements ◽  
Specific Gene ◽  
Genome Wide ◽  
Obesity Phenotype ◽  
Methylation Patterns ◽  
Subcutaneous Adipose

AbstractObesity, a risk factor for various human diseases originates through complex interactions between genes and prevailing environment that varies across populations. Indians exhibit a unique obesity phenotype likely attributed by specific gene pool and environmental factors. Here, we present genome-wide association study (GWAS) of 7,259 Indians to understand the genetic architecture of body mass index (BMI) in the population. Our study revealed novel association of variants in BAI3 (rs6913677) and SLC22A11 (rs2078267) at GWAS significance, and of ZNF45 (rs8100011) with near GWAS significance. As genetic loci may dictate the phenotype through modulation of epigenetic processes, we overlapped discovered genetic signatures with DNA methylation patterns of 236 Indian individuals, and analyzed expression of the candidate genes using publicly available data. The variants in BAI3 and SLC22A11 were found to dictate methylation patterns at unique CpGs harboring critical cis- regulatory elements. Further, BAI3, SLC22A11 and ZNF45 variants were found to overlie repressive chromatin, active enhancer, and active chromatin regions, in that order, in human subcutaneous adipose tissue in ENCODE database. Besides, the identified genomic regions represented potential binding sites for key transcription factors implicated in obesity and/or metabolic disorders. Interestingly, rs8100011 (ZNF45) acted as a robust cis-expression quantitative trait locus (cis-eQTL) in subcutaneous adipose tissue in GTEx portal, and ZNF45 gene expression showed an inverse correlation with BMI in skeletal muscle of Indian subjects. Further, gene-based GWAS analysis revealed CPS1 and UPP2 as additional leads regulating BMI in Indians. Our study decodes potential genomic mechanisms underlying obesity phenotype in Indians.

Association of subcutaneous and visceral fat with circulating microRNAs in a middle-aged Japanese population

2017 ◽  
Vol 55 (4) ◽  
pp. 437-445 ◽  
Author(s):  
Eiji Munetsuna ◽  
Hiroya Yamada ◽  
Yoshitaka Ando ◽  
Mirai Yamazaki ◽  
Yoshiki Tsuboi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Adipose Tissue ◽  
Body Mass ◽  
Body Fat ◽  
Visceral Fat ◽  
Subcutaneous Adipose Tissue ◽  
Circulating Microrna ◽  
High Group ◽  
Circulating Micrornas ◽  
Subcutaneous Adipose

Purpose It has been demonstrated that circulating microRNA profiles are affected by physiological conditions. Several studies have demonstrated that microRNAs play important roles in the regulation of adiposity. However, few have investigated the relationship between circulating microRNAs and obesity, which has become a major public health problem worldwide. This study investigated the association between circulating microRNAs and obesity in a Japanese population. Methods Obesity parameters, such as subcutaneous and visceral fat adipose tissue, body fat percentage, and body mass index were assessed in a cross-sectional sample of 526 participants who attended health examinations in Yakumo, Japan. In addition, five circulating microRNAs (miR-20a, -21, -27a, -103a, and -320), which are involved in adipocyte proliferation and differentiation, were quantified using real-time polymerase chain reaction amplification. Results We compared the circulating microRNA concentrations in a percentile greater than 75th (high) with below the value (low) of subcutaneous adipose tissue, visceral fat adipose tissue, body mass index, and per cent body fat. For visceral fat adipose tissue, significant decrease in miR-320 expression was observed in high group. Also, for body mass index, significant change of miR-20a, -27a, 103a, and 320 expression level was observed in high group. Multiple linear regression analysis demonstrated that circulating levels of some microRNA such as miR-27a were significantly associated with subcutaneous adipose tissue, visceral fat adipose tissue, and body mass index. Conclusions Our findings support the need for further studies to determine whether such changes are consistent across different populations and whether the identified microRNAs may represent novel biomarkers to predict the susceptibility and progression of obesity-related disorders.

scholarly journals Body mass index affects proliferation and osteogenic differentiation of human subcutaneous adipose tissue-derived stem cells

2013 ◽  
Vol 14 (1) ◽  
pp. 34 ◽  
Author(s):  
Trivia P Frazier ◽  
Jeffrey M Gimble ◽  
Jessica W Devay ◽  
Hugh A Tucker ◽  
Ernest S Chiu ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Stem Cells ◽  
Adipose Tissue ◽  
Osteogenic Differentiation ◽  
Body Mass ◽  
Subcutaneous Adipose Tissue ◽  
Subcutaneous Adipose

Competitive Performance of Kenyan Runners Compared to their Relative Body Weight and Fat

2020 ◽  
Author(s):  
Marietta Sengeis ◽  
Wolfram Müller ◽  
Paul Störchle ◽  
Alfred Fürhapter-Rieger
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Adipose Tissue ◽  
Body Mass ◽  
Body Fat ◽  
Subcutaneous Adipose Tissue ◽  
Leg Length ◽  
Long Distance ◽  
Relative Body Weight ◽  
Subcutaneous Adipose

AbstractBody fat values obtained with various measurement methods deviate substantially in many cases. The standardised brightness-mode ultrasound method was used in 32 Kenyan elite long-distance runners to measure subcutaneous adipose tissue thicknesses at an accuracy and reliability level not reached by any other method. Subcutaneous adipose tissue forms the dominating part of body fat. Additionally, body mass (m), height (h), sitting height (s), leg length, and the mass index MI1 =0.53m/(hs) were determined. MI1 considers leg length, which the body mass index ignores. MI1 values of all participants were higher than their body mass indices. Both indices for relative body weight were within narrow ranges, although thickness sums of subcutaneous adipose tissue deviated strongly (women: 20–82 mm; men: 3–36 mm). Men had 2.1 times more embedded fasciae in the subcutaneous adipose tissue. In the subgroup with personal best times below world record time plus 10%, no correlation between performance and body mass index was found, and there was also no correlation with sums of subcutaneous adipose tissue thicknesses. Within the data ranges found here, extremely low relative body weight or low body fat were no criteria for the level of performance, therefore, pressure towards too low values may be disadvantageous.

Does body mass index or subcutaneous adipose tissue thickness affect interfraction prostate motion in patients receiving radical prostate radiotherapy?

2016 ◽  
Vol 15 (4) ◽  
pp. 334-340 ◽  
Author(s):  
Jonathan Rogers ◽  
Camarie Welgemoed ◽  
Dorothy Gujral
Keyword(s):  
Body Mass Index ◽  
Adipose Tissue ◽  
Body Mass ◽  
Subcutaneous Adipose Tissue ◽  
Linear Regression Analysis ◽  
Fiducial Marker ◽  
Tissue Thickness ◽  
Prostate Motion ◽  
Significant Difference ◽  
Subcutaneous Adipose

AbstractAimIt is unclear whether body mass index (BMI) is a useful measurement for examining prostate motion. Patient’s subcutaneous adipose tissue thickness (SAT) and weight has been shown to correlate with prostate shifts in the left/right direction. We sought to analyse the relationship between BMI and interfraction prostate movement in order to determine planning target volume (PTV) margins based on patient BMI.Materials and methodsIn all, 38 prostate cancer patients with three implanted gold fiducial markers in their prostate were recruited. Height, mass and SAT were measured, and the extent of interfraction prostate movement in the left/right, superior/inferior and anterior/posterior directions was recorded during each daily fiducial marker-based image-guided radiotherapy treatment. Mean corrective shift in each direction for each patient, along with BMI values, were calculated.ResultsThe median BMI value was 28·4 kg/m2 (range 21·4–44·7). Pearson’s product-moment correlation analysis showed no significant relationship between BMI, mass or SAT and the extent of prostate movement in any direction. Linear regression analysis also showed no relationship between any of the patient variables and the extent of prostate movement in any direction (BMI: R2=0·006 (ρ=0·65), 0·002 (ρ=0·80) and 0·001 (ρ=0·86); mass: R2=0·001 (ρ=0·87), 0·010 (ρ=0·54) and 0·000 (ρ=0·99); SAT: R2=0·012 (ρ=0·51), 0·013 (ρ=0·50) and 0·047 (ρ=0·19) for shifts in the X, Y and Z axis, respectively). Patients were grouped according to BMI, as BMI<30 (n=25, 65·8%) and BMI≥30 (n=13, 34·2%). A two-tailed t-test showed no significant difference between the mean prostate shifts for the two groups in any direction (ρ=0·320, 0·839 and 0·325 for shifts in the X, Y and Z axis, respectively).FindingsBMI is not a useful parameter for determining individualised PTV margins. Gold fiducial marker insertion should be used as standard to improve treatment accuracy.

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