Influence of administration of 1 % glucose solution on neonatal blood glucose concentration in cesarean section

2012 ◽  
Vol 27 (2) ◽  
pp. 302-305 ◽  
Author(s):  
Tomoaki Yatabe ◽  
Hiroki Tateiwa ◽  
Nobuo Ikenoue ◽  
Sonoe Kitamura ◽  
Koichi Yamashita ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Cesarean Section ◽  
Glucose Concentration ◽  
Glucose Solution ◽  
Blood Glucose Concentration ◽  
Neonatal Blood

scholarly journals Effect of Spinal Anesthesia versus General Anesthesia on Blood Glucose Concentration in Patients Undergoing Elective Cesarean Section Surgery: A Prospective Comparative Study

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Khaled El-Radaideh ◽  
Ala’’a Alhowary ◽  
Mohammad Alsawalmeh ◽  
Ahmed Abokmael ◽  
Haitham Odat ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Cesarean Section ◽  
General Anesthesia ◽  
Spinal Anesthesia ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Elective Cesarean Section ◽  
Elective Cesarean ◽  
Prospective Comparative Study ◽  
The Mean

Background. This prospective study compared the blood glucose concentration with spinal anesthesia or general anesthesia in patients undergoing elective cesarean section surgery. Methods. In total, 58 pregnant women who underwent elective cesarean section surgery were included in this prospective comparative study. Group S (n = 35) included patients who chose spinal anesthesia, and group G (n = 23) included patients who chose general anesthesia. The patients were allocated to the groups upon patients’ preference. For the group G, the blood glucose concentration (BGC) was obtained 5 minutes before induction, T1, and 5 minutes after induction T2. For the group S, the BGC was obtained immediately before the injection of the local anesthetic agent T1 and 5 minutes after the complete block T2. For both groups, BGC was measured 5 minutes before the end of surgery T3 and 30 minutes after the end of surgery T4. For BGC measurements, we used a blood glucose monitoring system with a lancet device to prick the finger. Results. There was no statistically significant difference in the mean blood glucose concentration between the groups S and G in T1 (78.3 ± 18.2 vs. 74.3 ± 14.7, p>0.05) and T2 (79.2 ± 18.3 vs. 84.9 ± 23.7, p>0.05). The mean BGC was statistically significantly higher in group G in comparison to group S in the times 5 minutes before (80.2 ± 18.1 vs. 108.4 ± 16.7, p<0.05) and 30 minutes after the end of surgery (80.9 ± 17.7 vs. 121.1 ± 17.4, p<0.05). Conclusion. There is a much lower increase in blood glucose concentration under spinal anesthesia than under general anesthesia. It is reasonable to suggest that the blood sugar concentration must be intraoperatively monitored in patients undergoing general anesthesia.

Effect on blood glucose concentration of changes in availability of glucose to the brain

1963 ◽  
Vol 204 (6) ◽  
pp. 1127-1132 ◽  
Author(s):  
Kazuki Sakata ◽  
Shigeo Hayano ◽  
Henry A. Sloviter
Keyword(s):  
Blood Glucose ◽  
Glucose Concentration ◽  
Internal Carotid ◽  
Glucose Solution ◽  
Blood Glucose Concentration ◽  
Systemic Blood ◽  
Significant Difference ◽  
Sympathetic Nervous ◽  
The Brain ◽  
Glucose Curve

In the unanesthetized rabbit, systemic blood glucose concentration was measured periodically during the course of a slow, continuous infusion of glucose solution via the internal carotid artery. Under conditions otherwise identical, the same experiment was performed in the same rabbit, but the infusion was intravenous. In 7 of 14 such pairs of experiments, the curve of glucose concentration versus time was significantly lower for the intracarotid experiment and in the other seven cases there was no significant difference between the two curves. These results suggest that the brain responds to the increased concentration of glucose of its environment and by some mechanism acts to return it toward normal. Experiments were done in the same way with 2-deoxy-d-glucose, a substance which produces a cellular glucopenia. Of seven pairs of experiments, the systemic blood glucose curve was markedly higher in intracarotid infusion in three cases, moderately higher in two cases, and not significantly different in two cases from the curve for the intravenous infusion. These results suggest that the brain responds to decreased availability of glucose and acts, by way of the sympathetic nervous system, to raise the blood glucose concentration.

Relationship of Insulin Secretion Rate to Blood Glucose Concentration in Newborn and Adult Dogs

Neonatology ◽  
1969 ◽  
Vol 14 (3-4) ◽  
pp. 194-202 ◽  
Author(s):  
P.A.J. Adam ◽  
D. Kornhauser ◽  
D. Link ◽  
R. Schwartz
Keyword(s):  
Insulin Secretion ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Secretion Rate ◽  
Relationship Of ◽  
Insulin Secretion Rate

PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function

2014 ◽  
Vol 307 (4) ◽  
pp. H587-H597 ◽  
Author(s):  
Mark W. Sims ◽  
James Winter ◽  
Sean Brennan ◽  
Robert I. Norman ◽  
G. André Ng ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Concentration ◽  
Contractile Function ◽  
Blood Glucose Concentration ◽  
Specific Inhibitor ◽  
Wistar Rat ◽  
Patch Clamp Recording ◽  
Electrical Stability ◽  
Extracellular Glucose Concentration ◽  
Extracellular Glucose

While it is well established that mortality risk after myocardial infarction (MI) increases in proportion to blood glucose concentration at the time of admission, it is unclear whether there is a direct, causal relationship. We investigated potential mechanisms by which increased blood glucose may exert cardiotoxicity. Using a Wistar rat or guinea-pig isolated cardiomyocyte model, we investigated the effects on cardiomyocyte function and electrical stability of alterations in extracellular glucose concentration. Contractile function studies using electric field stimulation (EFS), patch-clamp recording, and Ca2+ imaging were used to determine the effects of increased extracellular glucose concentration on cardiomyocyte function. Increasing glucose from 5 to 20 mM caused prolongation of the action potential and increased both basal Ca2+ and variability of the Ca2+ transient amplitude. Elevated extracellular glucose concentration also attenuated the protection afforded by ischemic preconditioning (IPC), as assessed using a simulated ischemia and reperfusion model. Inhibition of PKCα and β, using Gö6976 or specific inhibitor peptides, attenuated the detrimental effects of glucose and restored the cardioprotected phenotype to IPC cells. Increased glucose concentration did not attenuate the cardioprotective role of PKCε, but rather activation of PKCα and β masked its beneficial effect. Elevated extracellular glucose concentration exerts acute cardiotoxicity mediated via PKCα and β. Inhibition of these PKC isoenzymes abolishes the cardiotoxic effects and restores IPC-mediated cardioprotection. These data support a direct link between hyperglycemia and adverse outcome after MI. Cardiac-specific PKCα and β inhibition may be of clinical benefit in this setting.

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