Higher hepatic sterol-binding protein-2 gene expression and serum triglyceride level in methimazole induced subclinical hypothyroid animal model

2021 ◽  
Author(s):  
Marie Saghaeian Jazi ◽  
Mohammad Mostakhdem Hashemi ◽  
Abbas Nezhadebrahimi ◽  
Azadreza Mansourian
Keyword(s):  
Gene Expression ◽  
Animal Model ◽  
Triglyceride Level ◽  
Binding Protein ◽  
Serum Triglyceride ◽  
Serum Triglyceride Level ◽  
Hypothyroid Animal ◽  
Sterol Binding

scholarly journals Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice

2021 ◽  
Vol 9 (5) ◽  
pp. 505
Author(s):  
Jingyi Yuan ◽  
Song Qin ◽  
Wenjun Li ◽  
Yubing Zhang ◽  
Yuting Wang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Triglyceride Level ◽  
Lactobacillus Reuteri ◽  
Binding Protein ◽  
Serum Triglyceride ◽  
Serum Triglyceride Level ◽  
Lipopolysaccharide Binding Protein ◽  
Lactobacillus Gasseri ◽  
Lactobacillus Animalis ◽  
Lipopolysaccharide Binding

Fucoidan is a kind of polysaccharide with antitumor and antioxidant properties, which is mainly isolated from brown algae. Although there are many reports about the prebiotic effects of polysaccharides on hosts, there are few reports about the effects of fucoidan on blood biochemical indexes, intestinal microbiome, and metabolic function on healthy hosts. We applied 16S rRNA gene amplicon sequencing and LC-MS/MS metabolomics to evaluate the changes in the gut microbiome and metabolite profiles of fucoidan treatment in mice over 10 weeks. Fucoidan treatment modulated lipid metabolism, including significantly decreasing serum triglyceride level in healthy mice. Fucoidan also significantly inhibited serum lipopolysaccharide-binding protein (LBP) concentration, a biomarker of endotoxemia. Correlation analysis further showed that Lactobacillus animalis populations that were enriched by fucoidan demonstrated significantly negative correlations with serum triglyceride level. The abundance of Lactobacillus gasseri and Lactobacillus reuteri, increased by fucoidan supplementation, demonstrated significantly negative correlation with lipopolysaccharide-binding protein levels. Lactobacillus gasseri also demonstrated significantly positive correlations with three tryptophan-related metabolites, including indoleacrylic acid, 3-indoleacrylic acid, and 5-hydroxytryptamine, which were all increased by fucoidan administration. Combined with the previous evidence, the results indicate that fucoidan exerts prebiotic effects, such as lipid metabolism suppression and metabolic endotoxemia suppression, by modulating the abundance of gut microbiota, such as Lactobacillus animalis, Lactobacillus gasseri, and Lactobacillus reuteri, as well as microbiota-dependent metabolites, such as tryptophan-related metabolites.

scholarly journals Effect of serum triglyceride level on the prognosis of patients with hepatocellular carcinoma in the absence of cirrhosis

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Xiaoli Liu ◽  
Mengge Li ◽  
Xinhui Wang ◽  
Zhibo Dang ◽  
Yuyong Jiang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Triglyceride Level ◽  
Serum Triglyceride ◽  
Serum Triglyceride Level

scholarly journals Effects of Hamo NK hard capsule on experimental atherosclerosis model

2021 ◽  
Vol 141 (5) ◽  
pp. 95-103
Author(s):  
Pham Thuy Phuong ◽  
Pham Thi Van Anh ◽  
Dang Thi Thu Hien ◽  
Nguyen Trong Thong ◽  
Pham Quoc Binh
Keyword(s):  
Oral Administration ◽  
Triglyceride Level ◽  
High Fat Diet ◽  
Biochemical Parameters ◽  
Serum Triglyceride ◽  
Experimental Atherosclerosis ◽  
Serum Triglyceride Level ◽  
High Fat ◽  
Blood Samples ◽  
Aortic Artery

This study evaluated the effects of Hamo NK hard capsule on athresclerosis using experimental atherosclerosis model. NewZealand White rabbits were fed a high-fat diet (HFD) containing cholesterol and peanut oil. The animals received oral administration of HFD and Hamo NK hard capsule at two doses of 0.126 and 0.378 g/kg bw/day for 8 consecutive weeks. Blood samples were collected for analyis of biochemical parameters at before treatment, week 4 and week 8. Histopathology assessments of the aortic artery and liver were carried out at the end of the experiment. Hamo NK was effective in reducing serum triglyceride level after 8 weeks of the experiment. In addition, Hamo NK at two doses of 0.126 g/kg b.w and 0.378 g/kg b.w for 8 consecutive weeks did not affect the cholesterol, LDL-C and HDL-C concentrations induced by a HFD. Hamo NK at the dose of 0.126 g/kg bw/day was not only able to decrease significant aortic surface lesions but also capable of managing atherosclerosis plaques formation in aorta; whereas theses activities were not notiaceable at the dose of 0.378 g/kg b.w.

scholarly journals Glucosyl Hesperidin Lowers Serum Triglyceride Level in Hypertriglyceridemic Subjects through the Improvement of Very Low-Density Lipoprotein Metabolic Abnormality

2005 ◽  
Vol 51 (6) ◽  
pp. 460-470 ◽  
Author(s):  
Yoshikatsu MIWA ◽  
Hitoshi MITSUZUMI ◽  
Takahiro SUNAYAMA ◽  
Mika YAMADA ◽  
Katsuhide OKADA ◽  
...  
Keyword(s):  
Triglyceride Level ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Metabolic Abnormality ◽  
Serum Triglyceride Level ◽  
Very Low Density Lipoprotein ◽  
Low Density

MP6-19 PREOPERATIVE SERUM TRIGLYCERIDE LEVEL IS A POTENTIAL PREDICTOR OF BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Minyong Kang ◽  
Chang Wook Jeong ◽  
Ja Hyeon Ku ◽  
Cheol Kwak ◽  
Hyeon Hoe Kim
Keyword(s):  
Radical Prostatectomy ◽  
Triglyceride Level ◽  
Biochemical Recurrence ◽  
Serum Triglyceride ◽  
Serum Triglyceride Level ◽  
Potential Predictor ◽  
Preoperative Serum

Effect of atorvastatin 10 mg and of simvastatin 20 mg on serum triglyceride level

2000 ◽  
Vol 151 (1) ◽  
pp. 47
Author(s):  
A Branchi ◽  
A.M Fiorenza ◽  
A Torri ◽  
F Muzio ◽  
A Rovellini ◽  
...  
Keyword(s):  
Triglyceride Level ◽  
Serum Triglyceride ◽  
Serum Triglyceride Level

Association between blood polychlorinated biphenyl concentration and serum triglyceride level in chronic ?Yusho? (polychlorinated biphenyl poisoning) patients

1993 ◽  
Vol 65 (4) ◽  
pp. 221-225 ◽  
Author(s):  
Yoshio Hirota ◽  
Kyoichiro Kataoka ◽  
Shoji Tokunaga ◽  
Tomio Hirohata ◽  
Shiro Shinohara ◽  
...  
Keyword(s):  
Triglyceride Level ◽  
Polychlorinated Biphenyl ◽  
Serum Triglyceride ◽  
Serum Triglyceride Level

Triglyceride levels and risk of type 2 diabetes mellitus: a longitudinal large study

2016 ◽  
Vol 64 (2) ◽  
pp. 383-387 ◽  
Author(s):  
Amani Beshara ◽  
Eytan Cohen ◽  
Elad Goldberg ◽  
Pearl Lilos ◽  
Moshe Garty ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Impaired Fasting Glucose ◽  
Triglyceride Level ◽  
Fasting Glucose ◽  
Fasting Blood Glucose ◽  
Serum Triglyceride ◽  
Stepwise Logistic Regression ◽  
Serum Triglyceride Level ◽  
Normal Range ◽  
Wide Range

The relationship between triglyceridemia and diabetes mellitus remains unclear. This study evaluated the risk of diabetes and impaired fasting glucose associated with a wide range of triglyceride levels. A longitudinal retrospective study was carried out employing data from a screening center between the years 2000 and 2012. Inclusion criteria were absence of diabetes at baseline and attendance at the center at least twice over a 5-year period. Participants were divided by fasting blood glucose level (normal/impaired) at the first visit. A total of 5085 participants were eligible for the study. Of the 4164 normoglycemic participants at baseline, 40 (0.96%) had diabetes and 998 (24%) had impaired fasting glucose by the end of the study. On stepwise logistic regression analysis, every 10 mg/dL increase in triglyceride level significantly increased the risk of diabetes by 4% and of impaired fasting glucose by 2% (p<0.001). This association held true even when rising triglyceride levels remained within the accepted normal range (<150 mg/dL, p<0.001). Sustained increments in serum triglyceride level, even within the accepted normal range, are an independent risk factor for diabetes mellitus and impaired fasting glucose in normoglycemic participants.

Lowering effects of four different statins on serum triglyceride level

1999 ◽  
Vol 55 (7) ◽  
pp. 499-502 ◽  
Author(s):  
A. Branchi ◽  
A. M. Fiorenza ◽  
A. Rovellini ◽  
A. Torri ◽  
F. Muzio ◽  
...  
Keyword(s):  
Triglyceride Level ◽  
Serum Triglyceride ◽  
Serum Triglyceride Level

Bicyclol, a synthetic dibenzocyclooctadiene derivative, decreases hepatic lipids but increases serum triglyceride level in normal and hypercholesterolaemic mice

2007 ◽  
Vol 59 (12) ◽  
pp. 1657-1662 ◽  
Author(s):  
Si-Yuan Pan ◽  
Hang Dong ◽  
Zhi-Ling Yu ◽  
Xin-Ye Zhao ◽  
Chun-Jing Xiang ◽  
...  
Keyword(s):  
Triglyceride Level ◽  
Serum Triglyceride ◽  
Serum Triglyceride Level ◽  
Hepatic Lipids
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