A decision analysis to identify the ideal treatment for adult spinal deformity: is surgery better than non-surgical treatment in improving health-related quality of life and decreasing the disease burden?

2016 ◽  
Vol 25 (8) ◽  
pp. 2390-2400 ◽  
Author(s):  
Emre Acaroglu ◽  
◽  
Aysun Cetinyurek Yavuz ◽  
Umit Ozgur Guler ◽  
Selcen Yuksel ◽  
...  
2017 ◽  
Vol 30 (2) ◽  
pp. E124-E131 ◽  
Author(s):  
Joshua Bakhsheshian ◽  
Justin K. Scheer ◽  
Jeffrey L. Gum ◽  
Lance Horner ◽  
Richard Hostin ◽  
...  

Author(s):  
Lisa Van Wilder ◽  
Brecht Devleesschauwer ◽  
Els Clays ◽  
Stefanie De Buyser ◽  
Johan Van der Heyden ◽  
...  

Abstract Background Chronic diseases and multimorbidity are a major cause of disease burden—for patients, caregivers, and society. Little is known however about potential interaction effects between specific disease combinations. Besides an additive effect, the presence of multiple conditions could also act synergistically or antagonistically regarding the impact on patients’ health-related quality of life (HRQoL). The aim was to estimate the impact of coexisting chronic diseases on HRQoL of the adult general Belgian population. Methods The Belgian Health Interview Survey 2018 provided data on self-reported chronic conditions and HRQoL (EQ-5D-5L) for a nationally representative sample. Linear mixed models were used to analyze two-way and three-way interactions of disease combinations on HRQoL. Results Multimorbidity had a prevalence of 46.7% (≥ 2 conditions) and 29.7% (≥ 3 conditions). HRQoL decreased considerably with the presence of multiple chronic diseases. 14 out of 41 dyad combinations and 5 out of 13 triad combinations showed significant interactions, with a dominant presence of negative/synergistic effects. Positive/antagonistic effects were found in more subjective chronic diseases such as depression and chronic fatigue. Conditions appearing the most frequently in significant disease pair interactions were dorsopathies, respiratory diseases, and arthropathies. Conclusions Diverse multimorbidity patterns, both dyads and triads, were synergistically or antagonistically associated with lower HRQoL. Tackling the burden of multimorbidity is needed, especially because most disease combinations affect each other synergistically, resulting in a greater reduction in HRQoL. Further knowledge about those multimorbidity patterns with a greater impact on HRQoL is needed to better understand disease burden beyond mortality and morbidity data.


2021 ◽  
Author(s):  
Shinya Tsuzuki ◽  
Yusuke Miyazato ◽  
Mari Terada ◽  
Shinichiro Morioka ◽  
Norio Ohmagari ◽  
...  

AbstractBackgroundThe empirical basis for a quantitative assessment of the disease burden imposed by long-COVID is currently scant. We aimed to assess the disease burden caused by long-COVID in Japan.MethodsWe conducted a cross sectional self-report questionnaire survey. The questionnaire was mailed to 530 eligible patients, who were recovered from acute COVID-19 in April 2021. Answers were classified into two groups; participants who have no symptom and those who have any ongoing symptoms that lasted longer than four weeks at the time of the survey. We compared health-related quality of life scores estimated by the EQ-5D-3L questionnaire between these two groups after adjusting basic characteristics of the participants by propensity score matching.Results349 participants reported no symptoms and 108 reported any symptoms at the time of the survey. The participants who reported any symptoms showed a lower value on a Visual Analogue Scale (median 70 [IQR 60-80]) and on the EQ-5D-3L (median 0.81 [IQR 0.77-1.0]) than those reporting no symptoms (median 85 [IQR 75-90] and 1.0 [IQR 1.0-1.0], respectively). After adjusting for background characteristics, these trends did not change substantially (Visual Analog Scale: median 70 [IQR 60-80] vs 80 [IQR 77-90], EQ-5D-3L: median 0.81 [IQR 0.76-1.0] vs 1.0 [IQR 1.0-1.0]).ConclusionsDue to their long duration, long-COVID symptoms represent a substantial disease burden expressed in impact on health-related quality of life.Trial registrationNot applicable.


2018 ◽  
Vol 112 ◽  
pp. e548-e554 ◽  
Author(s):  
Daniel B.C. Reid ◽  
Alan H. Daniels ◽  
Tamir Ailon ◽  
Emily Miller ◽  
Daniel M. Sciubba ◽  
...  

Scoliosis ◽  
2015 ◽  
Vol 10 (S1) ◽  
Author(s):  
Sho Kobayashi ◽  
Tomohiko Hasegawa ◽  
Yu Yamato ◽  
Tatsuya Yasuda ◽  
Hideyuki Arima ◽  
...  

2018 ◽  
Vol 18 (9) ◽  
pp. 1612-1624 ◽  
Author(s):  
Thamrong Lertudomphonwanit ◽  
Michael P. Kelly ◽  
Keith H. Bridwell ◽  
Lawrence G. Lenke ◽  
Steven J. McAnany ◽  
...  

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