IPSS “bother question” score predicts health-related quality of life better than total IPSS score

Background: Epilepsy is associated with stigma and bad health-related quality of life (HR-QOL) due to this, and side effects of the drug therapy. Newer anti-epileptics are claimed to be better than the conventional. We evaluated this based on comparison of HR-QOL in patients taking the respective therapy.Methods: An observational, cross-sectional, single point study involved 127 consenting patients from Neurology OPD at V.S. General Hospital. Quality of life in epilepsy-10 (QOLIE-10) questionnaire was used to measure HR-QOL in patients. SPSS software and Graphpad prism were used to analyze the variables.Results: Patients of 20-30 age group were commonly affected (37.80%) with a male predominance (56.69%). 41.73% were unemployed. The difference in HR-QOL between patients and controls in all three domains (epilepsy effects, mental effects, role function domains) of QOLIE-10 was significant (p=0.0002), indicating better HR-QOL in controls. The worst HR-QOL scores were found in Epilepsy effects domain. Metabolic adverse effects (38.58%) were the common ADRs. Sodium valproate was the most effective in controlling seizures (last seizure episode: 15 months). HR-QOL correlation between patients receiving monotherapy and polytherapy was significant (p=0.026) with monotherapy rendering a better HR-QOL. Comparison of HR-QOL between patients taking the conventional and the newer drugs was not significant (p=0.1768).Conclusions: Our study nullifies the claims that newer drugs are better than the conventional since no such benefit was seen in HR-QOL as well as ADRs. Our findings ruled out the belief that cases of epilepsy are better controlled with polytherapy.

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HEALTH-RELATED QUALITY OF LIFE IN KIDNEY TRANSPLANT PATIENTS WAS BETTER THAN THOSE IN CHRONIC KIDNEY DISEASE PATIENTS AT CKD STAGE 1-3

Transplantation Journal ◽

10.1097/01.tp.0000700836.32712.54 ◽

2020 ◽

Vol 104 (S3) ◽

pp. S439-S439

Author(s):

Jung-Hwa Ryu ◽

Hee Jung Jeon ◽

Tae Yeon Koo ◽

Kook-Hwan Oh ◽

Curie Ahn ◽

...

Keyword(s):

Quality Of Life ◽

Health Related Quality ◽

Transplant Patients ◽

Ckd Stage ◽

Related Quality ◽

Health Related ◽

Kidney Transplant Patients ◽

Stage 1 ◽

Better Than

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Multispecies Probiotic Maintains Health Related Quality of Life in Cirrhosis Better than Placebo

Journal of Hepatology ◽

10.1016/s0168-8278(16)00262-2 ◽

2016 ◽

Vol 64 (2) ◽

pp. S249

Author(s):

A. Horvath ◽

B. Leber ◽

D. Fuchs ◽

B. Schmerboeck ◽

M. Tawdrous ◽

...

Keyword(s):

Quality Of Life ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Better Than

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Prospective Evaluation of Health-Related Quality of Life in a Homogeneous Mediterranean Group of Colorectal Cancer Patients

The American Surgeon ◽

10.1177/000313481007600518 ◽

2010 ◽

Vol 76 (5) ◽

pp. 502-508 ◽

Cited By ~ 3

Author(s):

George E. Theodoropoulos ◽

Joanna G. Papailiou ◽

Paraskevas L. Stamopoulos ◽

Christina Golemati ◽

Dimitrios Tsamis ◽

...

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Cancer Patients ◽

Short Form ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Colorectal Cancer Patients ◽

Better Than

This study was designed to prospectively evaluate health-related quality of life in a homogeneous Mediterranean group of colorectal cancer patients. Ninety-five colorectal cancer patients were preoperatively assessed and followed-up with by skilled investigators using the Short Form-36 Health Survey questionnaire. Overall, patients showed deterioration in all domains, except for pain, when baseline values were compared with 3 and 6 months postoperatively ( P = 0.0001). A significant improvement of all Short Form-36 Health Survey questionnaire domains was noted between 6 and 12 months ( P = 0.0001). Scores for general health, pain, emotional well-being, and role limitations due to emotional problems at 1 year were shown better than preoperative ( P < 0.001). Improved scores in role limitations due to physical health and emotional problems were found at baseline and at 1 year, when laparoscopic were compared with open resections ( P < 0.05). Patients that received chemotherapy proved to be more vulnerable regarding their energy, social functioning, and role limitations at 3 months ( P < 0.05), whereas older patients had diminished physical functioning at 3 and 6 and 12 months ( P < 0.05) postoperatively. Greek colorectal cancer patients remain fragile up to 6 months after surgery, with significant improvements at 1 year, whereas certain aspects of health-related quality of life at 1 year may be even better than before surgery

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Health-related quality-of-life assessment in accordance with reconstruction procedures for distal gastrectomy for stage I gastric cancer using data from JCOG0912.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.4562 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. 4562-4562

Author(s):

Keiichi Fujiya ◽

Masahiko Ando ◽

Junki Mizusawa ◽

Hitoshi Katai ◽

Takanobu Yamada ◽

...

Keyword(s):

Quality Of Life ◽

Gastric Cancer ◽

Health Related Quality ◽

Reconstruction Procedure ◽

Reflux Symptoms ◽

Reconstruction Methods ◽

Related Quality ◽

Health Related ◽

Better Than

4562 Background: There are three major reconstruction methods after gastrectomy for distal gastric cancer; Billroth-I (B-I), Roux-en-Y (RY) and pylorus-preserving gastrectomy (PPG). These procedures can affect postoperative health-related quality-of-life (HRQoL), but the method is often selected due to physician’s preference or each institutional policy without solid evidence. We aimed to explore differences in HRQoL after each reconstruction procedure selected in JCOG0912, a phase III noninferiority trial comparing open and laparoscopic distal gastrectomies for stage I gastric cancer. Methods: Among 33 institutions participated in JCOG0912, 4 major cancer centers were selected for HRQoL assessment. HRQoL was assessed using the EORTC QLQ-C30 and STO22 before (baseline) and at 1, 3, 12, and 36 months after surgery as preplanned exploratory analysis. Results: Excluding 2 patients who didn’t answer the questionnaire, 590 patients were analyzed in this study. For reconstruction, B-I was performed for 222 patients (37.7%), RY for 178 (30.2%) and PPG for 189 (32.1%). Proportion of the opted reconstruction procedures was not different in open and laparoscopic gastrectomies. Global health status (GHS) scores of QLQ-C30 were not different among 3 groups at any time point. In comparison of B-I and RY, B-I was better than RY in constipation, while RY was better than B-I in diarrhea and reflux symptoms. In comparison of B-I and PPG, B-I was better than PPG in constipation and reflux symptoms, while PPG was better than B-I in diarrhea. When comparing RY and PPG, RY was better than PPG in constipation and reflux symptoms, while PPG was better than RY in taste (table). Conclusions: GHS scores were similar regardless of the reconstruction procedure, however postoperative symptoms including reflux, constipation, and diarrhea were various according to reconstruction methods. [Table: see text]

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Health-related quality of life in adults undergoing transthoracic device closure of ventricular septal defect

Journal of Cardiothoracic Surgery ◽

10.1186/s13019-019-1004-x ◽

2019 ◽

Vol 14 (1) ◽

Cited By ~ 1

Author(s):

Kai-Peng Sun ◽

Qiang Chen ◽

Zhi-Nuan Hong ◽

Jiang-Shan Huang ◽

Hua Cao

Keyword(s):

Quality Of Life ◽

Septal Defect ◽

Adult Patients ◽

Control Group ◽

Health Related Quality ◽

Device Closure ◽

Related Quality ◽

Health Related ◽

Better Than

Abstract Objective To evaluate the health-related quality of life (HRQoL) of adult patients who underwent transthoracic device closure of ventricular septal defect (VSD). Methods During the perioperative and postoperative period, a standard scale involving eight dimensions was used to analyze the HRQoL of 85 adult patients who underwent thoracic device closure of VSD and 80 healthy adults located locally were randomly selected as the control group in our center. Results A total of 80 patients’ and 80 healthy adults’ questionnaires were received with complete feedback. Out of all of the items that were investigated, postoperative patients experienced better feelings in some dimensions than the control group. Postoperative feedback was also better than preoperative feedback in some dimensions. In the comparison of the subgroups of these patients, the scores of the elderly were lower than those of the young in most dimensions. Males had more positive feedback in two aspects (“role-physical” (p = 0.01) and “vitality” (p = 0.003)), whereas unmarried people seemed to have poor emotional responses (“role-emotional” (p < 0.01) and “vitality” (p = 0.023)). There was no significant difference in any dimensions except “social functioning” (p < 0.01) between people with different levels of education. Conclusions Most of the adult patients who underwent thoracic closure of VSD felt that they could lead a normal life. They seemed to have reasonably normal psychosocial responses compared to healthy controls. Many patients even though their HRQoL was better than healthy individuals.

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