Postoperative ratio of the maximum C-reactive protein level to the minimum peripheral lymphocyte count as a prognostic indicator for gastric cancer patients

Surgery Today ◽  
2018 ◽  
Vol 49 (3) ◽  
pp. 206-213 ◽  
Author(s):  
Yusuke Kono ◽  
Hiroaki Saito ◽  
Yuki Murakami ◽  
Yuji Shishido ◽  
Hirohiko Kuroda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Protein Level ◽  
Lymphocyte Count ◽  
Prognostic Indicator ◽  
Peripheral Lymphocyte ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Gastric Cancer Patients

Clinical Burden of C-Reactive Protein/Albumin Ratio before Curative Surgery for Gastric Cancer Patients

2017 ◽  
Vol 225 (4) ◽  
pp. S187
Author(s):  
Yuji Toiyama ◽  
Yasuhiko Mohri ◽  
Tadanobu Shimura ◽  
Hiromi Yasuda ◽  
Hiroyuki Fujikawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
C Reactive Protein ◽  
Curative Surgery ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Clinical Burden ◽  
Gastric Cancer Patients

scholarly journals C-reactive protein predicts recurrence after postoperative chemotherapy using S-1 in advanced gastric cancer patients

2019 ◽  
Vol 30 ◽  
pp. vi140
Author(s):  
Takayuki Shimizu ◽  
Mitsuru Ishizuka ◽  
Takao Arakawa ◽  
Takashi Suzuki ◽  
Kazuma Tago ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Cancer Patients ◽  
Postoperative Chemotherapy ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Gastric Cancer Patients

scholarly journals The Association of the Lymphocyte-to-C-Reactive-Protein Ratio With Gastric Cancer Patients Who Receive Curative Treatment

In Vivo ◽  
2021 ◽  
Vol 36 (1) ◽  
pp. 482-489
Author(s):  
TORU AOYAMA ◽  
MASATO NAKAZANO ◽  
SHINSUKE NAGASAWA ◽  
KENTARO HARA ◽  
KEISUKE KOMORI ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Curative Treatment ◽  
C Reactive Protein ◽  
Protein Ratio ◽  
Reactive Protein ◽  
Gastric Cancer Patients

scholarly journals Blood count and C-reactive protein evolution in gastric cancer patients with total gastrectomy surgery

2014 ◽  
Vol 27 (4) ◽  
pp. 234-236
Author(s):  
Attila CSENDES J. ◽  
Andrea MUÑOZ Ch. ◽  
Ana María BURGOS L.
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Total Gastrectomy ◽  
Blood Count ◽  
Normal Values ◽  
Complete Blood Count ◽  
Maximum Level ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Gastric Cancer Patients

BACKGROUND: The complete blood count (CBC) and C-reactive protein (CRP) are useful inflammatory parameters for ruling out acute postoperative inflammatory complications. AIM: To determine their changes in gastric cancer patients submitted to total gastrectomy. METHODS: This is a prospective study, with 36 patients with gastric cancer who were submitted to elective total gastrectomy. On the first, third and fifth postoperative day (POD), blood count and CRP changes were assessed. Patients with postoperative complications were excluded. RESULTS: Twenty-one (58%) were men and 15 (42%) women. The mean age was 65 years. The leukocytes peaked on the 1st POD with a mean of 13,826 u/mm³, and decreased to 8,266 u/mm³ by the 5th POD. The bacilliforms peaked on the 1st POD with a maximum value of 1.48%. CRP reached its maximum level on the 3rd POD with a mean of 144.64 mg/l±44.84. Preoperative hematocrit (HCT) was 35% and 33.67% by the 5th POD. Hemoglobin, showed similar values. CONCLUSIONS: Leukocytes increased during the 1st POD but reached normal values by the 5th POD. CRP peaked on the 3rd POD but did not reach normal values by the 5th POD.

Clinical significance and prognostic value of C-reactive protein/albumin ratio in gastric cancer

2020 ◽  
Author(s):  
Yan-jun Fu ◽  
Ke-zhi Li ◽  
Xin-qiang Liang ◽  
Zhi-qing Liang ◽  
Bai jihong
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Clinical Significance ◽  
Prognostic Value ◽  
Tnm Stage ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Gastric Cancer Patients

Abstract Background C-reactive protein/albumin ratio (CAR) is a novel prognostic biomarker in several malignancies. This study was aimed to evaluate the clinical significance and prognostic value of CAR in patients with gastric cancer. Methods The data of 205 gastric cancer patients who underwent surgery was retrospectively reviewed. The association with the clinical features and prognostic value of CAR in gastric cancer was analyzed. The data of this study was combined with previous studies to further determine the prognostic value of CAR in patients with gastric cancer. Results Cox analysis revealed that preoperative CAR was an independent prognosis indicator in patients with gastric cancer. High expression of CAR indicated a shorter survival time than those with lower expression. CAR has a higher prognostic value in the 1-, 3-, 5-years of overall survival in patients with gastric cancer. However, CAR has no significant difference regarding the gastric cancer patients’ age, gender and TNM stage. The discriminated value of CAR in TNM stage of gastric cancer was moderate. A meta-analysis by combining previous data and our data showed that preoperative CAR was significantly associated with the overall survival of patients with gastric cancer. Conclusions This study demonstrated that preoperative CAR was an independent prognostic indicator in the patients with gastric cancer who underwent surgery.

scholarly journals Prognostic value of lymphocyte-to-C-reactive protein ratio in patients with gastric cancer after surgery: a multicentre study

2020 ◽  
Vol 50 (10) ◽  
pp. 1141-1149 ◽  
Author(s):  
Chuan-bing Cheng ◽  
Qu-xia Zhang ◽  
Lv-Ping Zhuang ◽  
Jian-wei Sun
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Prognostic Marker ◽  
Predictive Value ◽  
Radical Gastrectomy ◽  
C Reactive Protein ◽  
Protein Ratio ◽  
Reactive Protein ◽  
Gastric Cancer Patients

Abstract Objective The immune inflammation-based score is recognized as a prognostic marker for cancer. However, the most accurate prognostic marker for patients with gastric cancer remains undetermined. We aimed to evaluate the predictive value of the lymphocyte-to-C-reactive protein ratio for outcomes in gastric cancer patients after radical gastrectomy. Methods A total of 607 gastric cancer patients treated at three Chinese institutions were included. Receiver operating characteristic curves were generated, and the areas under the curve were calculated to compare the predictive value among the inflammation-based score, lymphocyte-to-C-reactive protein ratio, C-reactive protein/albumin and neutrophil-lymphocyte, platelet-lymphocyte and lymphocyte-monocyte ratios. Cox regression was performed to determine the prognostic factors for overall survival. Results The median follow-up time was 63 months (range: 1–84 months). The optimal cut-off value for lymphocyte-to-C-reactive protein ratio was 0.63. The patients were divided into the LCR <0.63 (LLCR, n = 294) group and the LCR ≥0.63 (HLCR, n = 313) group. LLCR was significantly correlated with poor clinical characteristics. Compared with inflammation-based score, lymphocyte-to-C-reactive protein ratio had the highest areas under the curve (0.695). Patients with LLCR experienced more post-operative complications than the HLCR group (20.4 vs. 12.1%, P = 0.006). Multivariate analysis showed that a higher lymphocyte-to-C-reactive protein ratio (HR: 0.545, 95%CI: 0.372–0.799, P = 0.002) was associated with better overall survival. The HLCR group had higher 5-year overall survival rate than the LLCR group (80.5 vs. 54.9%, P < 0.001). Conclusions Preoperative lymphocyte-to-C-reactive protein ratio levels can effectively predict the short-term and oncological efficacy of gastric cancer patients after radical gastrectomy with a predictive value significantly better than other inflammation-based score.

scholarly journals Validation of C-reactive protein levels as a prognostic indicator for survival in a large cohort of pancreatic cancer patients

2013 ◽  
Vol 110 (1) ◽  
pp. 183-188 ◽  
Author(s):  
J Szkandera ◽  
M Stotz ◽  
G Absenger ◽  
T Stojakovic ◽  
H Samonigg ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Prognostic Indicator ◽  
Large Cohort ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Clinical significances of preoperative serum interleukin-6 and C-reactive protein level in operable gastric cancer

BMC Cancer ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Do-Kyong Kim ◽  
Sung Yong Oh ◽  
Hyuk-Chan Kwon ◽  
Suee Lee ◽  
Kyung A Kwon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Interleukin 6 ◽  
Protein Level ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Preoperative Serum
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