Oral administration of the biomimetic [Cr3O(O2CCH2CH3)6(H2O)3]+ increases insulin sensitivity and improves blood plasma variables in healthy and type 2 diabetic rats

2004 ◽  
Vol 10 (2) ◽  
pp. 119-130 ◽  
Author(s):  
Buffie J. Clodfelder ◽  
Bryan M. Gullick ◽  
Henry C. Lukaski ◽  
Yasmin Neggers ◽  
John B. Vincent
Keyword(s):  
Insulin Sensitivity ◽  
Oral Administration ◽  
Blood Plasma ◽  
Diabetic Rats ◽  
Type 2 Diabetic

scholarly journals Oral administration of the biomimetic [Cr3O(O2CCH2CH3)6(H2O)3]+ increases insulin sensitivity and improves blood plasma variables in healthy and type 2 diabetic rats

2005 ◽  
Vol 10 (3) ◽  
pp. 316-316 ◽  
Author(s):  
Buffie J. Clodfelder ◽  
Bryan M. Gullick ◽  
Henry C. Lukaski ◽  
Yasmin Neggers ◽  
John B. Vincent
Keyword(s):  
Insulin Sensitivity ◽  
Oral Administration ◽  
Blood Plasma ◽  
Diabetic Rats ◽  
Type 2 Diabetic

Beneficial effect of galanin on insulin sensitivity in muscle of type 2 diabetic rats

2011 ◽  
Vol 103 (3-4) ◽  
pp. 284-289 ◽  
Author(s):  
Biao He ◽  
Mingyi Shi ◽  
Ling Zhang ◽  
Guangzhi Li ◽  
Lingxiang Zhang ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Beneficial Effect ◽  
Diabetic Rats ◽  
Type 2 Diabetic

GW24-e2332 Berberine alleviates mesenteric artery endothelial dysfunction by improving insulin sensitivity in type 2 diabetic rats

Heart ◽  
2013 ◽  
Vol 99 (Suppl 3) ◽  
pp. A100.3-A101 ◽  
Author(s):  
Ling Dong ◽  
Feng-Hao Geng ◽  
Zhao Zhang ◽  
Peng Zhang ◽  
Wen-Juan Xing ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Endothelial Dysfunction ◽  
Mesenteric Artery ◽  
Diabetic Rats ◽  
Type 2 Diabetic

Comparative pharmacokinetics of baicalin in normal and the type 2 diabetic rats after oral administration of the Radix scutellariae extract

Fitoterapia ◽  
2012 ◽  
Vol 83 (8) ◽  
pp. 1435-1442 ◽  
Author(s):  
Yuan-Xiong Deng ◽  
Qun-Zhi Shi ◽  
Bo Chen ◽  
Xiao-Jie Zhang ◽  
Sheng-Zi Liu ◽  
...  
Keyword(s):  
Oral Administration ◽  
Diabetic Rats ◽  
Radix Scutellariae ◽  
Type 2 Diabetic

scholarly journals Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats

2018 ◽  
Vol 52 (1) ◽  
pp. 6-16 ◽  
Author(s):  
Ayodele Olufemi Morakinyo ◽  
Titilola Aderonke Samuel ◽  
Daniel Abiodun Adekunbi
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Glucose Transporter ◽  
Diabetic Rats ◽  
Glucose Transporter 4 ◽  
Magnesium Supplementation ◽  
Glucose Levels ◽  
Type 2 Diabetic

Abstract Objective. We investigated the effects of magnesium supplementation on glucose tolerance, insulin sensitivity, oxidative stress as well as the concentration of insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide induced type-2 diabetic (T2D) rats. Methods. Rats were divided into four groups designated as: 1) control (CTR); 2) diabetic untreated (DU); 3) diabetic treated with 1 mg of Mg/kg diet (Mg1-D); and 4) diabetic treated with 2 mg of Mg/kg diet (Mg2-D). T2D was induced with a single intraperitoneal (i.p.) injection of freshly prepared streptozotocin (55 mg/kg) aft er an initial i.p. injection of nicotinamide (120 mg/kg). Glucose tolerance, insulin sensitivity, lipid profile, malondialdehyde (MAD) and glutathione content, insulin receptors (INSR) and glucose transporter-4 (GLUT4), fasting insulin and glucose levels were measured, and insulin resistance index was calculated using the homeostatic model assessment of insulin resistance (HOMA-IR). Results. Magnesium supplementation improved glucose tolerance and lowered blood glucose levels almost to the normal range. We also recorded a noticeable increase in insulin sensitivity in Mg-D groups when compared with DU rats. Lipid perturbations associated T2D were significantly attenuated by magnesium supplementation. Fasting glucose level was comparable to control values in the Mg-D groups while the HOMA-IR index was significantly lower compared with the DU rats. Magnesium reduced MDA but increased glutathione concentrations compared with DU group. Moreover, INSR and GLUT4 levels were elevated following magnesium supplementation in T2D rats. Conclusion. These findings demonstrate that magnesium may mediate effective metabolic control by stimulating the antioxidant defense, and increased levels of INSR and GLUT4 in diabetic rats.

Sign in / Sign up

Export Citation Format

Share Document