scholarly journals A dual perspective on first-session therapeutic alliance: strong predictor of youth mental health and addiction treatment outcome

2020 ◽  
Vol 29 (11) ◽  
pp. 1593-1601 ◽  
Author(s):  
Patty van Benthem ◽  
Renske Spijkerman ◽  
Peter Blanken ◽  
Marloes Kleinjan ◽  
Robert R. J. M. Vermeiren ◽  
...  

Abstract We investigated the potential role of first-session therapeutic alliance ratings to serve as an early marker of treatment outcome in youth mental health and addiction treatment. The present study is among the first to incorporate both a youths’ and a therapists’ perspective of the therapeutic alliance in order to maximize predictive value of the alliance for treatment outcome. One hundred and twenty-seven adolescents participated in a multi-site prospective naturalistic clinical cohort study, with assessments at baseline and at 4 months post-baseline. Main outcome measure was favorable or unfavorable treatment outcome status at 4-month follow-up. Early therapeutic alliance had a medium and robust association with treatment outcome for youth’ (b = 1.29) and therapist’ (b = 1.12) perspectives and treatment setting. Based on the two alliance perspectives four subgroups were distinguished. Incorporating the alliance-ratings from both perspectives provided a stronger predictor of treatment outcome than using one perspective. Youth with a strong alliance according to both perspectives had an eightfold odds of favorable treatment outcome compared with youth with a weak alliance according to both perspectives. The association between therapeutic alliance and treatment outcome in youth mental health and addiction treatment may be substantially stronger than earlier assumed when both a youths’ and therapists’ perspective on alliance is considered.

2021 ◽  
Vol 12 ◽  
Author(s):  
Lisa-Katrin Kaufmann ◽  
Hanspeter Moergeli ◽  
Gabriella Franca Milos

Background: The body mass index is a key predictor of treatment outcome in patients with anorexia nervosa. In adolescents, higher premorbid BMI is a strong predictor of a favorable treatment outcome. It is unclear whether this relationship holds true for adults with anorexia nervosa. Here, we examine adult patients with AN and investigate the lowest and highest lifetime BMI and weight suppression as predisposing factors for treatment outcome.Methods: We included 107 patients aged 17–56 with anorexia nervosa and tracked their BMI from admission to inpatient treatment, through discharge, to follow-up at 1–6 years. Illness history, including lowest and highest lifetime BMI were assessed prior to admission. We used multiple linear regression models with minimal or maximal lifetime BMI or weight suppression at admission as independent variables to predict BMI at admission, discharge and follow-up, while controlling for patients' age, sex, and duration of illness.Results: Low minimal BMI had a negative influence on the weight at admission, which in turn resulted in a lower BMI at discharge. Higher maximal BMI had a substantial positive influence on BMI at discharge and follow-up. Weight suppression was highly correlated with maximal BMI and showed similar effects to maximal BMI.Conclusion: Our findings strongly support a relationship between low minimal lifetime BMI and lower BMI at admission, and between higher maximal lifetime BMI or weight suppression and a positive treatment outcome, even years after discharge. Overall, maximal BMI emerged as the most important factor in predicting the weight course in adults with AN.


2016 ◽  
Vol 26 (3) ◽  
pp. 259-272 ◽  
Author(s):  
Simone Orlowski ◽  
Sharon Lawn ◽  
Ben Matthews ◽  
Anthony Venning ◽  
Gabrielle Jones ◽  
...  

2007 ◽  
Vol 35 (3) ◽  
pp. 371-375 ◽  
Author(s):  
Thomas Lang ◽  
Jürgen Hoyer

This case example demonstrates the role of massed exposure in optimizing treatment outcome in panic disorder with agoraphobia. Treatment of a 28-year-old male patient in a clinical routine setting is described. Full remission was achieved after an 8 day period of intensive treatment and proved to be stable at follow-up (6 months). More systematic research including controlled studies comparing massed and spaced exposure is suggested.


2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 10558-10558
Author(s):  
Y. Koh ◽  
H. Kim ◽  
H. Lee ◽  
K. Lee ◽  
D. Oh ◽  
...  

10558 Background: Previous studies suggested the role of KIT and PDGFRAmutations on treatment outcome of GIST with IMT, but results are heterogeneous. IHC value of PDGFRA and PDGFRB is not established. Methods: We included patients (pts) treated with IMT as a first line therapy for metastastic or relapsed GIST between 2001 and 2008. Tumor DNA was extracted to investigate the mutation status of KITexon 9, exon 11, PDGFRA exon 12 and 18. IHC stain of c-KIT and PDGFRA/B was performed. We assessed the correlation between the treatment outcome, genetic status and IHC results. Results: A total of 85 pts (M:F=49:36, median age 58.4 years) received IMT 400 mg daily. Location of primary disease included stomach (33), small bowel (34), rectum (10), esophagus (1), and omentum/mesentery (7). Complete and partial responses were achieved in 6% and 62% of pts respectively, while 5% of pts had progressive disease. During median follow up of 28.1 months, estimated median PFS was 39.8 months. KIT exon 11 and 9 mutations were detected in 64% and 5% respectively. Exon 11 mutations included 44 deletions, 2 insertions, 5 substitutions and 3 deletion/insertions. PDGFRA exon 12 and 18 mutations were detected in 2% respectively. Positive rate of c-KIT, PDGFRA and PDGFRB using IHC was 96%, 21%, and 26% respectively. PDGFRA and PDGFRB were co-expressed (p=0.001). PDGFRA mutation did not correlate with PDGFRA/B expression. Clinical response was not different according to the mutation status or IHC expression. PFS of KIT exon 11, KITexon 9, PDGFRA mutants and pts without detectable mutations were not different (p=0.397). Pts with KIT exon 11 balanced mutations (substitution or deletion/insertion) showed longer PFS compared with pts with unbalanced mutations (deletion or insertion) (p=0.014) or pts without exon 11 mutations (p=0.033). Median PFS was shorter in pts lacking c-KIT (p=0.001) expression. PDGFRA/B expression did not influence PFS. Conclusions: Balanced mutation of KIT exon 11 predicted longer PFS, while lack of c-KIT protein expression predicted shorter PFS for GIST pts treated with first line IMT. PDGFRA and B were co-expressed without predictive value. No significant financial relationships to disclose.


2014 ◽  
Vol 184 (4) ◽  
pp. 831-843 ◽  
Author(s):  
E. Schaffalitzky ◽  
D. Leahy ◽  
W. Cullen ◽  
B. Gavin ◽  
L. Latham ◽  
...  

2016 ◽  
Vol 50 (5) ◽  
pp. 636-658 ◽  
Author(s):  
Rebecca J. Haines-Saah ◽  
Carla T. Hilario ◽  
Emily K. Jenkins ◽  
Cara K. Y. Ng ◽  
Joy L. Johnson

This article is based on findings from a qualitative study with 27 adolescents in northern British Columbia, Canada. Our aim was to explore youths’ perspectives on the sources of emotional distress in their lives and how these are connected to peer-based aggression and victimization within their community. Our analysis of narrative findings suggests that youths’ narratives about bullying reflect intersecting and socially embedded configurations of “race,” neocolonialism, and place. We argue that mainstream approaches to addressing bullying as a relationship-based problem must be re-oriented to account for the role of the social or structural contexts of youths’ lives. By applying an intersectional lens, we make the case for a widening of the focus of interventions away from individual victims and perpetrators, toward a contextual approach that addresses how adolescents experience bullying as a site of health and social inequities in their community.


2019 ◽  
Author(s):  
Jessica L. Schleider ◽  
Mallory Dobias ◽  
Susmita Pati

INTRODUCTION SUMMARY. Major depression in youth is a serious psychiatric illness with extensive acute and chronic morbidity and mortality. In 2018, the American Academy of Pediatrics released updated practice guidelines promoting screening of youth depression in primary care (PC) clinics across the country, representing a critical step towards increasing early depression detection. However, the challenge of bridging screening with service access remains. Even when diagnosed by PC providers, <50% of youth with elevated depressive symptoms access treatment of any kind. Thus, there is a need for interventions that are more feasible for youths and parents to access and complete—and that may strengthen parents’ likelihood of pursuing future, longer-term services for their child.Single-session interventions (SSIs) may offer a promising path toward these goals. SSIs include core elements of comprehensive, evidence-based treatments, but their brevity makes them easier to disseminate beyond traditional clinical settings. Indeed, SSIs can successfully treat youth psychopathology: In a meta-analysis of 50 randomized controlled trials, SSIs reduced youth mental health difficulties of multiple types (mean g=0.32). To date, one SSI has been shown to reduce youth depressive symptoms in multiple RCTs: the online “growth mindset” (GM) SSI, which teaches the belief that personal traits are malleable rather than fixed. As one example, a 30-minute GM-SSI led to significant 9-month MD symptom reductions in high-symptom youths ages 12-15 versus a supportive therapy control (N=96; ds=0.60, 0.32 per parent and youth reports). Thus, GM SSIs represents a scalable, evidence-based strategy for reducing youth depressive symptoms.GM-SSIs can also strengthen parent beliefs about the effectiveness of mental health treatment, which robustly predict whether youths ultimately access services. A recent RCT including 430 parents of youth ages 7-17 indicated that an online, 15-minute SSI teaching growth mindset of emotion (viewing emotions as malleable) significantly increased parents’ beliefs that psychotherapy could be effective, both for themselves (d=0.51) and their offspring (d=0.43), versus a psychoeducation control. By helping reverse parents’ low expectancies for treatment, this low-cost program may enhance parents’ odds of seeking services for children with mental health needs.Accordingly, this study will test whether empirically-supported GM-SSIs can help bridge the gap between PC-based depression screening and access to depression services for high-symptom youth. Youths reporting elevated internalizing symptoms at a PC visit will be randomly assigned to one of two conditions: Information, Psychoeducation, and Referral (IPR; i.e., usual care) or IPR enhanced with youth- and parent-directed online SSIs (IPR+SSI), designed to reduce youth internalizing symptoms and improve parents’ mental health treatment expectancies, respectively. We predict that (1) IPR+SSI will increase parents’ treatment-seeking behaviors, versus IPR alone, across 3-month follow-up; (2) IPR+SSI will reduce youth internalizing symptoms across 3-month follow-up versus IPR alone; (3) IPR+SSI will reduce parental stress and psychological distress across 3-month follow-up, versus IPR alone; (4) parents and youths will rate this service delivery model as acceptable.METHOD SUMMARY. Per youth-reported internalizing symptom elevations during a PC visit (score >=5 on the Pediatric Symptom Checklist internalizing subscale), eligible families (N=246; youth ages 11-16) will be invited to participate in the study. In online surveys, parents will self-report recent treatment-seeking behaviors, expectancies for psychotherapy, stress and psychological symptoms, and youth mental health problems, along with family and demographic information; youths will self-report symptom levels. Within the same survey, youths and parents will then be randomized (1:1 allocation ratio) to one of two experimental conditions (IPR+SSI or IPR alone); those assigned to IPR+SSI will complete an intervention feedback form immediately post-intervention. At 3-month follow-up, to assess SSI effects on parent treatment-seeking, parent stress and symptoms, and youth internalizing problems, participating youths and parents will complete the same questionnaires administered at baseline.SIGNIFICANCE. There is a need for novel, potent strategies to increase families’ access to youth mental health services following PC-based symptoms screening. Ideally, such strategies would be low-cost (e.g., those that do not require new staff); involve both parents and youths to address the myriad factors that may undermine service access; and impose minimal burdens on PC providers. Results will indicate whether one such strategy—providing online, low-cost SSIs to youths and parents—may help reduce youth internalizing symptoms and promote treatment-seeking in parents.


2021 ◽  
Author(s):  
Lisa-Katrin Kaufmann

Background: The body mass index is a key predictor of treatment outcome in patients with anorexia nervosa. In adolescents, higher premorbid BMI is a strong predictor of a favourable treatment outcome. It is unclear whether this relationship holds true for adults with anorexia nervosa. Here, we examine adult patients with AN and investigate the lowest and highest lifetime BMI and weight suppression as predisposing factors for treatment outcome.Methods: We included 107 patients aged 17-56 with anorexia nervosa and tracked their BMI from admission to inpatient treatment, through discharge, to follow-up at 1-6 years. Illness history, including lowest and highest lifetime BMI were assessed prior to admission. We used multiple linear regression models with minimal or maximal lifetime BMI or weight suppression at admission as independent variables to predict BMI at admission, discharge and follow-up, while controlling for patients’ age, sex, and duration of illness. Results: Low minimal BMI had a negative influence on the weight at admission, which in turn resulted in a lower BMI at discharge. Higher maximal BMI had a substantial positive influence on BMI at discharge and follow-up. Weight suppression was highly correlated with maximal BMI and showed similar effects to maximal BMI.Conclusion: Our findings strongly support a relationship between low minimal lifetime BMI and lower BMI at admission, and between higher maximal lifetime BMI or weight suppression and a positive treatment outcome, even years after discharge. Overall, maximal BMI emerged as the most important factor in predicting the weight course in adults with AN.


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