Evaluation of endothelial dysfunction in patients with familial Mediterranean fever: the relationship between the levels of asymmetric dimethylarginine and endocan with carotid intima–media thickness and endothelium-dependent vasodilation

Background Atherosclerosis is initiated by endothelial dysfunction, as a result of increasing degradation of nitrit oxide by reactive oxygen species, thereby increasing oxydative stress. Dyslipidemia is one of the risk factors of endothelial dysfunction. The aim of this study was to evaluate the relationship of blood pressure and serum lipid level with carotid intima-media thickness (CIMT) in subjects aged between 55-65 years. Methods A cross sectional study was carried out in 52 male and female subjects aged between 55-65 years. Age, gender, body mass index (BMI), blood pressure, lipid profile, and CIMT were assessed in all subjects. The independent t-test was used to to analyze the relationship between all variables and CIMT. The level of statistical significance was set at p<0.05 Results Mean age was 59.19 ± 3.68 years, prevalence of thickened CIMT was 66.5%, and plaques were found in 9 subjects. There wwre no significant differences in age, BMI, systolic and diastolic blood pressure, and lipid profile between normal and thickened CIMT (p>0.05). However, there was a significant difference in gender between the two groups (p=0.011). In females, mean systolic and diastolic blood pressure were higher in the thickened CIMT group than in the normal CIMT group, but the difference was not significant (p>0.05). Conclusions Our findings suggest that high blood pressure tends to increase CIMT in female adults. An increasing value of CIMT should be considered as a sign of cerebrovascular disease.

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Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients

Archives of Rheumatology ◽

10.5606/archrheumatol.2016.5628 ◽

2016 ◽

Vol 31 (2) ◽

pp. 112-120 ◽

Cited By ~ 1

Author(s):

Özlem Gürbüz

Keyword(s):

Familial Mediterranean Fever ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Glutathione S Transferase ◽

Media Thickness ◽

Mediterranean Fever

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Correlation of plasma levels of asymmetric dimethylarginine with carotid intima - Media thickness in hypertensive patients with endothelial dysfunction

Atherosclerosis ◽

10.1016/j.atherosclerosis.2014.05.322 ◽

2014 ◽

Vol 235 (2) ◽

pp. e118

Author(s):

M. Suciu ◽

M. Andor ◽

C. Cristescu ◽

L. Dragan ◽

L. Suciu ◽

...

Keyword(s):

Endothelial Dysfunction ◽

Plasma Levels ◽

Asymmetric Dimethylarginine ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Hypertensive Patients ◽

Media Thickness

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The evaluation of carotid intima-media thickness in children with familial Mediterranean fever

Clinical Rheumatology ◽

10.1007/s10067-007-0764-1 ◽

2007 ◽

Vol 27 (6) ◽

pp. 689-694 ◽

Cited By ~ 22

Author(s):

Harun Peru ◽

Bülent Altun ◽

Mustafa Doğan ◽

Fatih Kara ◽

Ahmet Midhat Elmaci ◽

...

Keyword(s):

Familial Mediterranean Fever ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Media Thickness ◽

Mediterranean Fever

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Endothelial Dysfunction and Inflammatory Markers of Vascular Disease

Current Vascular Pharmacology ◽

10.2174/1570161118666200421142542 ◽

2020 ◽

Vol 19 (3) ◽

pp. 243-249 ◽

Cited By ~ 1

Author(s):

Sevket Balta

Keyword(s):

Endothelial Dysfunction ◽

Vascular Disease ◽

Inflammatory Markers ◽

Vascular Diseases ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Non Invasive ◽

Von Willebrand ◽

The Relationship ◽

Willebrand Factor

: Vascular diseases are the main reason for morbidity and mortality worldwide. As we know, the earlier phase of vascular diseases is endothelial dysfunction in humans, the endothelial tissues play an important role in inflammation, coagulation, and angiogenesis, via organizing ligand-receptor associations and the various mediators’ secretion. We can use many inflammatory non-invasive tests (flowmediated dilatation, epicedial fat thickness, carotid-intima media thickness, arterial stiffness and anklebrachial index) for assessing the endothelial function. In addition, many biomarkers (ischemia modified albumin, pentraxin-3, E-selectin, angiopoietin, endothelial cell specific molecule 1, asymmetrical dimethylarginine, von Willebrand factor, endothelial microparticles and endothelial progenitor cells) can be used to evaluate endothelial dysfunction. We have focused on the relationship between endothelial dysfunction and inflammatory markers of vascular disease in this review.

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