scholarly journals Pain extent is associated with pain intensity but not with widespread pressure or thermal pain sensitivity in women with fibromyalgia syndrome

2017 ◽  
Vol 36 (6) ◽  
pp. 1427-1432 ◽  
Author(s):  
Marco Barbero ◽  
César Fernández-de-las-Peñas ◽  
María Palacios-Ceña ◽  
Corrado Cescon ◽  
Deborah Falla
Keyword(s):  
Pain Intensity ◽  
Pain Sensitivity ◽  
Fibromyalgia Syndrome ◽  
Thermal Pain ◽  
Thermal Pain Sensitivity ◽  
Pain Extent

scholarly journals Pain Sensitivity Subgroups in Individuals With Spine Pain: Potential Relevance to Short-Term Clinical Outcome

2014 ◽  
Vol 94 (8) ◽  
pp. 1111-1122 ◽  
Author(s):  
Rogelio A. Coronado ◽  
Joel E. Bialosky ◽  
Michael E. Robinson ◽  
Steven Z. George
Keyword(s):  
Cluster Analysis ◽  
High Pressure ◽  
Clinical Outcome ◽  
Pain Intensity ◽  
Pain Sensitivity ◽  
Thermal Pain ◽  
Dynamic Sensitivity ◽  
Spine Pain ◽  
Clinical Pain ◽  
Thermal Pain Sensitivity

Background Cluster analysis can be used to identify individuals similar in profile based on response to multiple pain sensitivity measures. There are limited investigations into how empirically derived pain sensitivity subgroups influence clinical outcomes for individuals with spine pain. Objective The purposes of this study were: (1) to investigate empirically derived subgroups based on pressure and thermal pain sensitivity in individuals with spine pain and (2) to examine subgroup influence on 2-week clinical pain intensity and disability outcomes. Design A secondary analysis of data from 2 randomized trials was conducted. Methods Baseline and 2-week outcome data from 157 participants with low back pain (n=110) and neck pain (n=47) were examined. Participants completed demographic, psychological, and clinical information and were assessed using pain sensitivity protocols, including pressure (suprathreshold pressure pain) and thermal pain sensitivity (thermal heat threshold and tolerance, suprathreshold heat pain, temporal summation). A hierarchical agglomerative cluster analysis was used to create subgroups based on pain sensitivity responses. Differences in data for baseline variables, clinical pain intensity, and disability were examined. Results Three pain sensitivity cluster groups were derived: low pain sensitivity, high thermal static sensitivity, and high pressure and thermal dynamic sensitivity. There were differences in the proportion of individuals meeting a 30% change in pain intensity, where fewer individuals within the high pressure and thermal dynamic sensitivity group (adjusted odds ratio=0.3; 95% confidence interval=0.1, 0.8) achieved successful outcomes. Limitations Only 2-week outcomes are reported. Conclusions Distinct pain sensitivity cluster groups for individuals with spine pain were identified, with the high pressure and thermal dynamic sensitivity group showing worse clinical outcome for pain intensity. Future studies should aim to confirm these findings.

scholarly journals Altered Neurotransmitter Ratio in the Prefrontal Cortex is Associated with Pain in Fibromyalgia Syndrome

2021 ◽  
Author(s):  
James H. Bishop ◽  
Afik Faerman ◽  
Andrew Geoly ◽  
Naushaba Khan ◽  
Claudia Tischler ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Pain Sensitivity ◽  
Fibromyalgia Syndrome ◽  
Positive Relationship ◽  
Critical Role ◽  
Resonance Spectroscopy ◽  
Gamma Aminobutyric Acid ◽  
Thermal Pain ◽  
Heat Pain Threshold ◽  
Thermal Pain Sensitivity

The central mechanisms underlying fibromyalgia syndrome (FMS) remain undetermined. The dorsolateral prefrontal cortex (DLPFC) is particularly relevant to FMS because it is implicated in cognitive, affective, and top-down pain regulation. Imbalances in excitatory (Glutamate) and inhibitory (Gamma aminobutyric acid; GABA) neurochemicals may play a critical role in the pathophysiology of the condition and more generally in homeostatic function within cortical circuits. Although the balance of excitation and inhibition are intrinsically linked no investigations to date have investigated the E/I ratio in FMS. Thus, the primary objective of this study was to determine whether the E/I ratio in the DLPFC is altered in participants with FMS compared to healthy controls using magnetic resonance spectroscopy. Additionally, we examined the relationship between E/I ratio and pain metrics. We hypothesized that the E/I ratio within the DLPFC would be altered in participants with FMS compared to controls and, secondly, that E/I ratio would be associated with both clinical pain and thermal pain sensitivity. The Brief Pain Inventory (BPI) self-assessment was used to evaluate pain severity and impact on physical functioning and acute pain sensitivity was determined via quantitative sensory testing to define thermal (heat) pain threshold and tolerance. Our results revealed an elevation in the E/I ratio in FMS compared to controls. A positive relationship between E/I ratio and thermal pain sensitivity measures was identified in the FMS cohort. Collapsing across groups, there was a positive relationship between E/I ratio and BPI score. These findings suggest that dysfunction in the balance between excitation and inhibition within cognitive brain circuitry may play a role in pain processing in FMS.

The Relationship among Physical Activity Level, Activity Type, and Thermal Pain Sensitivity

2016 ◽  
Vol 48 ◽  
pp. 116 ◽  
Author(s):  
Natalie R. Janzen ◽  
Jamie K. Huber ◽  
Shelbi L. Sutterfield ◽  
Carl J. Ade ◽  
E Laurette Taylor ◽  
...  
Keyword(s):  
Physical Activity ◽  
Physical Activity Level ◽  
Pain Sensitivity ◽  
Activity Level ◽  
Activity Type ◽  
Thermal Pain ◽  
Thermal Pain Sensitivity ◽  
The Relationship

scholarly journals Relationships between Irritable Bowel Syndrome Pain, Skin Temperature Indices of Autonomic Dysregulation, and Sensitivity to Thermal Cutaneous Stimulation

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Fong Wong ◽  
Anthony C. Rodrigues ◽  
Christopher D. King ◽  
Joseph L. Riley ◽  
Siegfried Schmidt ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pain Sensitivity ◽  
Thermal Hyperalgesia ◽  
Thermal Stimulation ◽  
Thermal Pain ◽  
Pain Ratings ◽  
Irritable Bowel ◽  
Thermal Pain Sensitivity ◽  
Pain Patients ◽  
Skin Temperatures

This study evaluated relationships between irritable bowel syndrome (IBS) pain, sympathetic dysregulation, and thermal pain sensitivity. Eight female patients with diarrhea-predominant IBS and ten healthy female controls were tested for sensitivity to thermal stimulation of the left palm. A new method of response-dependent thermal stimulation was used to maintain pain intensity at a predetermined level (35%) by adjusting thermal stimulus intensity as a function of pain ratings. Clinical pain levels were assessed prior to each testing session. Skin temperatures were recorded before and after pain sensitivity testing. The temperature of palmar skin dropped (1.5) when the corresponding location on the opposite hand of control subjects was subjected to prolonged thermal stimulation, but this response was absent for IBS pain patients. The patients also required significantly lower stimulus temperatures than controls to maintain a 35% pain rating. Baseline skin temperatures of patients were significantly correlated with thermode temperatures required to maintain 35% pain ratings. IBS pain intensity was not significantly correlated with skin temperature or pain sensitivity. The method of response-dependent stimulation revealed thermal hyperalgesia and increased sympathetic tone for chronic pain patients, relative to controls. Similarly, a significant correlation between resting skin temperatures and thermal pain sensitivity for IBS but not control subjects indicates that tonic sympathetic activation and a thermal hyperalgesia were generated by the chronic presence of visceral pain. However, lack of a significant relationship between sympathetic tone and ratings of IBS pain casts doubt on propositions that the magnitude of IBS pain is determined by psychological stress.

scholarly journals Therapeutic Exercise and Pain Neurophysiology Education in Female Patients with Fibromyalgia Syndrome: A Feasibility Study

2020 ◽  
Vol 9 (11) ◽  
pp. 3564
Author(s):  
Luis Ceballos-Laita ◽  
María Teresa Mingo-Gómez ◽  
Francisco Navas-Cámara ◽  
Elena Estébanez-de-Miguel ◽  
Santos Caudevilla-Polo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Psychological Distress ◽  
Pain Intensity ◽  
Pain Sensitivity ◽  
Fibromyalgia Syndrome ◽  
Pain Catastrophizing ◽  
Therapeutic Exercise ◽  
Short Term

Background: We compared the effects of therapeutic exercise (TE) combined with pain neurophysiology education (PNE) to those of TE in isolation on pain intensity, general fibromyalgia impact, mechanical pain sensitivity, pain catastrophizing, psychological distress and quality of life in women with fibromyalgia syndrome (FMS). Methods: A feasibility study with a 3 month follow-up was designed. Thirty-two patients with FMS were randomly assigned to PNE + TE group (n = 16) or to TE group (n = 16). Both groups received 30 sessions of TE (3 per week), and the PNE + TE group received eight face-to-face educational sessions. The measuring instruments used were the visual analogue scale, a standard pressure algometer, the Revised Fibromyalgia Impact Questionnaire, the Pain Catastrophizing Scale, the Hospital Anxiety and Depression Scale and the Health Assessment Questionnaire. Results: The PNE + TE group showed a statistically significant decrease on pain intensity compared to TE group at short term (p = 0.015). No between-groups differences were found for mechanical pain sensitivity, general fibromyalgia impact, pain catastrophizing, psychological distress or quality of life (p > 0.05). Conclusions: The combination of PNE and TE was more effective than TE for reducing pain intensity in the short-term. No differences were found for psychological distress, pain catastrophizing and quality of life after the intervention or at 3 months of follow-up.

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