Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats

2021 ◽  
Author(s):  
Wei Hu ◽  
Ya-Wei Su ◽  
Yi-Kun Jiang ◽  
Wen-Di Fan ◽  
Song-Yue Cheng ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Near Infrared ◽  
Diabetic Rats ◽  
Infrared Light ◽  
Solution Temperature ◽  
Near Infrared Light ◽  
Critical Solution Temperature ◽  
Polymer Vesicles ◽  
Upper Critical Solution Temperature

Separable Microneedles for Near-Infrared Light-Triggered Transdermal Delivery of Metformin in Diabetic Rats

2018 ◽  
Vol 4 (8) ◽  
pp. 2879-2888 ◽  
Author(s):  
Yang Zhang ◽  
Danfeng Wang ◽  
Mengyue Gao ◽  
Bin Xu ◽  
Jiangying Zhu ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Near Infrared ◽  
Diabetic Rats ◽  
Infrared Light ◽  
Near Infrared Light

Near-infrared light triggered and separable microneedles for transdermal delivery of metformin in diabetic rats

2017 ◽  
Vol 5 (48) ◽  
pp. 9507-9513 ◽  
Author(s):  
Weijiang Yu ◽  
Guohua Jiang ◽  
Yang Zhang ◽  
Depeng Liu ◽  
Bin Xu ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Thermal Ablation ◽  
Near Infrared ◽  
Diabetic Rats ◽  
Infrared Light ◽  
Near Infrared Light

We successfully developed a microneedle system integrated with a near-infrared light trigger and thermal ablation microneedles for transdermal delivery of metformin on diabetic rats.

scholarly journals Off-on switching of enzyme activity by near-infrared light-induced photothermal phase transition of nanohybrids

2019 ◽  
Vol 5 (8) ◽  
pp. eaaw4252 ◽  
Author(s):  
Song Zhang ◽  
Changping Wang ◽  
Hong Chang ◽  
Qiang Zhang ◽  
Yiyun Cheng
Keyword(s):  
Phase Transition ◽  
Enzyme Activity ◽  
Near Infrared ◽  
Infrared Light ◽  
Solution Temperature ◽  
Photothermal Effect ◽  
Platinum Nanoparticle ◽  
Near Infrared Light ◽  
Upper Critical Solution Temperature ◽  
New Strategy

The off-on manipulation of enzyme activity is a challenging task. We report a new strategy for reversible off-on control of enzyme activity by near-infrared light. Enzymes acting on macromolecular substrates are embedded with an ultrasmall platinum nanoparticle and decorated with thermoresponsive copolymers, which exhibit upper critical solution temperature (UCST) behavior. The polymer-enzyme nanohybrids form microscale aggregates in solution below the UCST to prevent macromolecular substrates from approaching the enzymes and thus inhibit the enzyme activity, and they disassemble above the UCST to reactivate the enzyme. Upon near-infrared irradiation, platinum nanoparticles inside the enzymes generate heat through a photothermal effect to cause phase transition of the copolymers. Therefore, we can reversibly switch off and on the activities of three enzymes acting on polysaccharide, protein, and plasmid. The enzyme activities are increased by up to 61-fold after laser irradiation. This study provides a facile and efficient method for off-on control of enzyme activity.

Upper critical solution temperature polymer-grafted hollow mesoporous silica nanoparticles for near-infrared-irradiated drug release

2019 ◽  
Vol 7 (38) ◽  
pp. 5789-5796 ◽  
Author(s):  
Wei Hu ◽  
Xiaowen Bai ◽  
Yaping Wang ◽  
Zhentao Lei ◽  
Haipeng Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Near Infrared ◽  
Mesoporous Silica Nanoparticles ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Promising Strategy ◽  
Upper Critical Solution Temperature ◽  
Hollow Mesoporous Silica

A near-infrared (NIR)-responsive drug delivery system was established by grafting UCST polymers on the surfaces of hollow mesoporous silica nanoparticles (HMSNs) using the photothermal agent indocyanine green (ICG), which provided a new and promising strategy for drug delivery.

Near-infrared light induced fusion and fission of azobenzene-containing polymer vesicles

RSC Advances ◽  
2013 ◽  
Vol 3 (46) ◽  
pp. 23997 ◽  
Author(s):  
Kang Sun ◽  
Kun Chen ◽  
Guosheng Xue ◽  
Jun Cai ◽  
Gang Zou ◽  
...  
Keyword(s):  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Polymer Vesicles

An ordered copper nanowell-array film with near-perfect broadband absorption from ultraviolet to near-infrared light

2020 ◽  
Vol 59 (11) ◽  
pp. 110906
Author(s):  
Juan Shen ◽  
Yong Ren ◽  
Xinxin Zhu ◽  
Min Mao ◽  
Quan Zhou ◽  
...  
Keyword(s):  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Broadband Absorption

scholarly journals Recent Near-Infrared Light-Activated Nanomedicine toward Precision Cancer Therapy

2021 ◽  
Author(s):  
Xiaowei Luan ◽  
Yongchun Pan ◽  
Yanfeng Gao ◽  
Yujun Song
Keyword(s):  
Cancer Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Human Society ◽  
Near Infrared Light ◽  
History Of ◽  
The Universe

Light has witnessed the history of mankind and even the universe. It is of great significances to the life of human society, contributing to energy, agriculture, communication, and much more....

Selective Hydrogen Bonding Controls Temperature Response of Layer-by-Layer Upper Critical Solution Temperature Micellar Assemblies

Soft Matter ◽  
2021 ◽  
Author(s):  
Aliaksei Aliakseyeu ◽  
Victoria Albright ◽  
Danielle Yarbrough ◽  
Samantha Hernandez ◽  
Qing Zhou ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Methacrylic Acid ◽  
Temperature Response ◽  
Solution Temperature ◽  
Layer By Layer ◽  
Critical Solution Temperature ◽  
Hydrogen Bonding Interactions ◽  
Upper Critical Solution Temperature ◽  
Lbl Films

This work establishes a correlation between the selectivity of hydrogen-bonding interactions and the functionality of micelle-containing layer-by-layer (LbL) assemblies. Specifically, we explore LbL films formed by assembly of poly(methacrylic acid)...

Sign in / Sign up

Export Citation Format

Share Document