Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death

Twelve phosphonopropionates derived from 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid (3-IPEHPC) were synthesized and evaluated for their activity as inhibitors of protein geranylgeranylation. The nature of the substituent in the C6 position of imidazo[1,2-a]pyridine ring was responsible for the compound's activity against Rab geranylgeranyl transferase (RGGT). The most active inhibitors disrupted Rab11A prenylation in the human cervical carcinoma HeLa cell line. The esterification of carboxylic acid in the phosphonopropionate moiety turned the inhibitor into an inactive analog.

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Antiapoptotic activity of methyl (3R,4E,6Z,15E)-3-hydroxyoctadecatrienoate in human cervical carcinoma HeLa cells

Bioscience Biotechnology and Biochemistry ◽

10.1093/bbb/zbaa006 ◽

2021 ◽

Vol 85 (2) ◽

pp. 228-232

Author(s):

Osamu Ohno ◽

Keigo Sato ◽

Ryo Honma ◽

Ruri Chiba ◽

Kenji Matsuno

Keyword(s):

Cell Death ◽

Cervical Carcinoma ◽

Column Chromatography ◽

Hela Cells ◽

Active Compound ◽

Inhibitory Activity ◽

Marine Organisms ◽

Meoh Extract ◽

Human Cervical Carcinoma ◽

Antiapoptotic Activity

ABSTRACT Inhibitors of thapsigargin-induced cell death in human cervical carcinoma HeLa cells were screened among the metabolites of marine organisms. The MeOH extract of the cyanobacterium Rivularia sp. was found to exhibit inhibitory activity. Column chromatography purification was used to isolate methyl (3R,4E,6Z,15E)-3-hydroxyoctadecatrienoate (MHO) as the active compound. MHO was determined to inhibit apoptotic stimuli-induced cell death in HeLa cells.

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Triflavin, an Arg-Gly-Asp-containing peptide, inhibits human cervical carcinoma (HeLa) cell-substratum adhesion through an RGD-dependent mechanism

Peptides ◽

10.1016/0196-9781(94)90114-7 ◽

1994 ◽

Vol 15 (8) ◽

pp. 1391-1398 ◽

Cited By ~ 10

Author(s):

Joen Rong Sheu ◽

Chao Hsin Lin ◽

Hui Chin Peng ◽

Tur Fu Huang

Keyword(s):

Hela Cell ◽

Cervical Carcinoma ◽

Human Cervical Carcinoma ◽

Dependent Mechanism

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Role of mitochondria and mitochondrial cytochrome c in tubeimoside I-mediated apoptosis of human cervical carcinoma HeLa cell line

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-005-0047-y ◽

2005 ◽

Vol 57 (3) ◽

pp. 389-399 ◽

Cited By ~ 23

Author(s):

Fang Wang ◽

Rundi Ma ◽

Lijian Yu

Keyword(s):

Cytochrome C ◽

Hela Cell ◽

Cell Line ◽

Cervical Carcinoma ◽

Mitochondrial Cytochrome ◽

Hela Cell Line ◽

Human Cervical Carcinoma ◽

Tubeimoside I ◽

Mitochondrial Cytochrome C

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Yuk-Hap-Tang Induces Apoptosis by Intervening Mn-SOD in Human Cervical Carcinoma HeLa Cells

The American Journal of Chinese Medicine ◽

10.1142/s0192415x04002491 ◽

2004 ◽

Vol 32 (06) ◽

pp. 883-895 ◽

Cited By ~ 9

Author(s):

H. J. Chae ◽

J. M. Park ◽

G. Y. Lee ◽

H. R. Park ◽

S. W. Chae ◽

...

Keyword(s):

Cell Death ◽

Cervical Carcinoma ◽

Anticancer Agents ◽

Hela Cells ◽

Caspase 3 ◽

Reduced Glutathione ◽

Cleavage Product ◽

P53 Expression ◽

Human Cervical Carcinoma ◽

Apoptotic Protein

Yuk-Hap-Tang (YHT) induces cell death in human cervical carcinoma HeLa cells. Caspase-3, -6 and -9 were markedly activated in HeLa cells treated with YHT. The preferred substrate for caspase-3 cysteine protease, PARP, was cleaved to its 85-kDa cleavage product. YHT increased the amount of the anti-apoptotic protein, Bcl-2, and the pro-apoptotic protein, Bax. Although p53 has been reported to accumulate in cancer cells in response to anticancer agents, the p53 expression level was not changed in HeLa cells treated with YHT. Manganese (Mn)-TBAP, a mitochondria-specific SOD mimetic agent and NAC/GSH (N-acetyl cysteine/reduced glutathione) reduced the YHT-induced cytotoxicity and decreased the number of the YHT-induced apoptotic cells. Furthermore, YHT reduced the expression of Mn-SOD protein and its activity in HeLa cells. The data demonstrate that YHT induces the apoptosis of human cervical carcinoma HeLa cells by intervening Mn-SOD.

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