Computed tomography-based analyses of baseline body composition parameters and changes in breast cancer patients under treatment with CDK 4/6 inhibitors

CONTEXT AND OBJECTIVE: Changes in metabolism have been reported in the majority of patients undergoing cancer treatment, and these are usually characterized by progressive change in body composition. The effects of aerobic exercise programs to combat the cancer and cancer treatment-related side effects, which include the negative changes in body composition, have been extensively reported in the literature. However, few resistance exercise intervention studies have hypothesized that breast cancer patients might benefit from this type of exercise. The purpose of this study was to determine whether exercise protocols that emphasize resistance training would change body composition and strength in breast cancer patients undergoing treatment. DESIGN AND SETTING: Randomized controlled trial, at the Campus Recreation Center and Rocky Mountain Cancer Rehabilitation Institute of the University of Northern Colorado, and the North Colorado Medical Center. METHODS: Twenty inactive breast cancer patients were randomly assigned to a 21-week exercise group (n = 10) or a control group (n = 10). The exercise group trained at low to moderate intensity for 60 minutes on two days/week. The primary outcome measurements included body composition (skinfold method) and muscle strength (one repetition maximum). RESULTS: Significant differences in lean body mass, body fat and strength (p = 0.004, p = 0.004, p = 0.025, respectively) were observed between the groups at the end of the study. CONCLUSION: The results suggest that exercise emphasizing resistance training promotes positive changes in body composition and strength in breast cancer patients undergoing treatment.

Download Full-text

Computed Tomography (CT) Scan Evaluation of Late Toxicity Following Hypofractionated/Accelerated Radiotherapy With Cytoprotection (HypoARC) in Breast Cancer Patients Treated With Conservative Surgery

American Journal of Clinical Oncology ◽

10.1097/01.coc.0000227482.36289.f2 ◽

2006 ◽

Vol 29 (5) ◽

pp. 479-483 ◽

Cited By ~ 3

Author(s):

John Manavis ◽

John Ambatzoglou ◽

Kyriaki Sismanidou ◽

Michael I. Koukourakis

Keyword(s):

Breast Cancer ◽

Computed Tomography ◽

Ct Scan ◽

Cancer Patients ◽

Late Toxicity ◽

Conservative Surgery ◽

Breast Cancer Patients ◽

Accelerated Radiotherapy

Download Full-text

P237 The impact of body composition change on neo-adjuvant chemotherapy for breast cancer patients

The Breast ◽

10.1016/s0960-9776(15)70269-9 ◽

2015 ◽

Vol 24 ◽

pp. S106-S107

Author(s):

T. Iwase ◽

T. Sangai ◽

E. Ishigami ◽

J. Sakakibara ◽

K. Fujisaki ◽

...

Keyword(s):

Breast Cancer ◽

Body Composition ◽

Adjuvant Chemotherapy ◽

Cancer Patients ◽

Composition Change ◽

Breast Cancer Patients ◽

Body Composition Change ◽

Neo Adjuvant Chemotherapy ◽

The Impact

Download Full-text

An observational study of post-operative Volumetric Modulated Arc Radiotherapy (VMAT) of breast cancer by immobilizing patients on All-in-one (AIOTM) solution Breast and Lung Board without usingthermoplastic mask: Risk of collusion of gantry with couch exists if acquisition of Cone-beam Computed Tomography (CBCT)is attempted for set-up verification.

10.21203/rs.3.rs-24920/v1 ◽

2020 ◽

Author(s):

Ramaiah Vinay Kumar

Keyword(s):

Breast Cancer ◽

Computed Tomography ◽

Cancer Patients ◽

Target Volume ◽

Cone Beam ◽

Breast Cancer Patients ◽

Unilateral Breast Cancer ◽

Planar Image ◽

X Ray ◽

Set Up

Abstract Background: Automatic Cone-beam computed tomography (CBCT) based image matching for set-up verification is recommended as compared to 2-D match for post-operative local / loco-regional radiotherapy of breast cancer patients by Volumetric Modulated Arc Therapy (VMAT) technique. However, in supine position, off-midline peripheral body Clinical Target Volume (CTV) of unilateral breast cancer patients immobilized on Breast and Lung board of All-in-One (AIO) positioning systemmay necessitate augmented movement of couch in ‘x’ and ‘z’ axis thereby raising the risk of collusion of x-ray sources / detectors system with couch. Methods and Materials: VMAT was planned by a pair of partial arc for whole target volume for seven consecutive post-operative breast cancer patients (five post-mastectomy and two post-breast conservation patients). Tattoo based set-up by shift of treatment table in x-, y- and z-axis as determined by Treatment Planning System followed by X-rays with planar image acquisition and online 2-D imaging matching was performed for set-up verification. In-room 360°rotation of x-ray source and detector system of linear accelerator (linac) was performed before x-ray planar image acquisition. Results: Completion of 360°rotation in-room of x-ray source and detector system of linacaround the machine iso-centre was not possible in six out of seven patients due to possibility of collusion of gantry with contralateral side of the couch. Conclusion: Performing CBCT for generating 3D images for computed tomography (CT) reconstruction may not be practical for patient set-up verification of post-operative radiotherapy of unilateral breast cancer patients positioned supine on breast and lung board.

Download Full-text