scholarly journals Rate and Predictors of Persistent Major Depressive Disorder in a Nationally Representative Sample

2014 ◽  
Vol 51 (6) ◽  
pp. 701-707 ◽  
Author(s):  
Elizabeth Reisinger Walker ◽  
Benjamin G. Druss
2012 ◽  
Vol 201 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Femke Lamers ◽  
Marcy Burstein ◽  
Jian-ping He ◽  
Shelli Avenevoli ◽  
Jules Angst ◽  
...  

BackgroundAlthough techniques such as latent class analysis have been used to derive empirically based subtypes of depression in adult samples, there is limited information on subtypes of depression in youth.AimsTo identify empirically based subtypes of depression in a nationally representative sample of US adolescents, and to test the comparability of subtypes of depression in adolescents with those derived from a nationally representative sample of adults.MethodRespondents included 912 adolescents and 805 adults with a 12-month major depressive disorder, selected from the National Comorbidity Survey Adolescent Supplement and the National Comorbidity Survey Replication samples respectively. Latent class analysis was used to identify subtypes of depression across samples. Sociodemographic and clinical correlates of derived subtypes were also examined to establish their validity.ResultsThree subtypes of depression were identified among adolescents, whereas four subtypes were identified among adults. Two of these subtypes displayed similar diagnostic profiles across adolescent and adult samples (P=0.43); these subtypes were labelled ‘severe typical’ (adults 45%, adolescents 35%) and ‘atypical’ (adults 16%, adolescents 26%). The latter subtype was characterised by increased appetite and weight gain.ConclusionsThe structure of depression observed in adolescents is highly similar to the structure observed in adults. Longitudinal research is necessary to evaluate the stability of these subtypes of depression across development.


2011 ◽  
Vol 168 (3) ◽  
pp. 257-264 ◽  
Author(s):  
Andrew E. Skodol ◽  
Carlos M. Grilo ◽  
Katherine M. Keyes ◽  
Timothy Geier ◽  
Bridget F. Grant ◽  
...  

2011 ◽  
Vol 26 (S2) ◽  
pp. 842-842
Author(s):  
A. Manetti ◽  
N. Hoertel ◽  
Y. Le Strat ◽  
J.-P. Schuster ◽  
F. Limosin

IntroductionDepression in later life is a major public heath issue. Few studies to date examined the psychiatric correlates of depression in elderly surveys in the general population.ObjectiveTo provide nationally representative data on the prevalence, sociodemographic correlates and comorbidity of current major depressive disorder in late life.MethodsThis study is based on a nationally representative survey, the National Epidemiologic Survey on Alcohol and Related Conditions, of the noninstitutionalized household population (8,205 respondents aged 65 and above). The past 12-months prevalence of major depressive disorder was estimated, and logistic regression analyses were used to examine the relationship between 12-months major depressive disorder and sociodemographic characteristics, general medical condition and psychiatric disorder. Diagnoses were made according to the of DSM-IV criteria.ResultsAmong the respondents, 3.2% individuals with a past 12-months diagnosis of major depressive disorder were identified. Women and individuals living in urban areas were more likely to be diagnosed with a major depressive disorder. Significant associations between major depressive disorder and cardiovascular, gastrointestinal diseases, arthritis were found. Several psychiatric disorder were associated with past 12-months major depressive disorder, including dysthymia, bipolar disorder, panic disorder, specific phobia, generalized anxiety disorder, nicotine and alcohol dependence, and histrionic personality disorder.ConclusionRecent Major depressive disorder in the elderly was associated with a large number of psychiatric disorders. This study highlights the need to develop effective and targeted intervention initiatives to detect major depressive disorder in elderly.


2012 ◽  
Vol 200 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Cheng-Ta Li ◽  
Ya-Mei Bai ◽  
Yu-Lin Huang ◽  
Ying-Sheue Chen ◽  
Tzeng-Ji Chen ◽  
...  

BackgroundPeople with major depressive disorder who fail to respond to adequate trials of antidepressant treatment may harbour hidden bipolar disorder.AimsWe aimed to compare the rates of a change in diagnosis to bipolar disorder among people with major depressive disorder with stratified responses to antidepressants during an 8-year follow-up period.MethodInformation on individuals with major depressive disorder identified during 2000 (cohort 2000, n = 1485) and 2003 (cohort 2003, n = 2459) were collected from a nationally representative cohort of 1 000 000 health service users in Taiwan. Participants responding well to antidepressants were compared with those showing poor responses to adequate trials of antidepressants.ResultsIn 7.6–12.1% of those with a diagnosis of unipolar major depressive disorder this diagnosis was subsequently changed to bipolar disorder, with a mean time to change of 1.89–2.98 years. Difficult-to-treat participants presented higher rates of change to a bipolar diagnosis (25.6% in cohort 2000; 26.6% in cohort 2003) than easy-to-treat participants (8.8–8.9% in cohort 2000; 6.8–8.6% in cohort 2003; P<0.0001). Regression analysis showed that the variable most strongly associated with the change in diagnosis was antidepressant use history. The difficult-to-treat participants were associated most with diagnostic changing (cohort 2000: odds ratio (OR) = 1.88 (95% CI 1.12–3.16); cohort 2003: OR = 4.94 (95% CI 2.81–8.68)).ConclusionsThis is the first large-scale study to report an association between antidepressant response history and subsequent change in diagnosis from major depressive disorder to bipolar disorder. Our findings support the view that a history of poor response to antidepressants in unipolar depression could be a useful predictor for bipolar diathesis.


Sign in / Sign up

Export Citation Format

Share Document