Synthesis, antimicrobial activity, and structure–activity relationships of eugenol, menthol, and genistein esters

2011 ◽  
Vol 47 (4) ◽  
pp. 550-555 ◽  
Author(s):  
Gulay Zengin
Keyword(s):  
Antimicrobial Activity ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure-Activity Relationships of Protoberberines Having Antimicrobial Activity

Planta Medica ◽  
1998 ◽  
Vol 64 (08) ◽  
pp. 748-751 ◽  
Author(s):  
Kinuko Iwasa ◽  
Hiroaki Nanba ◽  
Dong-Ung Lee ◽  
So-lm Kang
Keyword(s):  
Antimicrobial Activity ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals The Antimicrobial Activity of Cannabinoids

Antibiotics ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 406
Author(s):  
John A. Karas ◽  
Labell J. M. Wong ◽  
Olivia K. A. Paulin ◽  
Amna C. Mazeh ◽  
Maytham H. Hussein ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Natural Products ◽  
Antimicrobial Agents ◽  
Cannabis Sativa ◽  
Antimicrobial Properties ◽  
Herbaceous Plant ◽  
Structure Activity Relationships ◽  
Modes Of Action ◽  
Structure Activity ◽  
Rapid Emergence

A post-antibiotic world is fast becoming a reality, given the rapid emergence of pathogens that are resistant to current drugs. Therefore, there is an urgent need to discover new classes of potent antimicrobial agents with novel modes of action. Cannabis sativa is an herbaceous plant that has been used for millennia for medicinal and recreational purposes. Its bioactivity is largely due to a class of compounds known as cannabinoids. Recently, these natural products and their analogs have been screened for their antimicrobial properties, in the quest to discover new anti-infective agents. This paper seeks to review the research to date on cannabinoids in this context, including an analysis of structure–activity relationships. It is hoped that it will stimulate further interest in this important issue.

Highly functionalized pyranopyrazoles: synthesis, antimicrobial activity, simulation studies and their structure activity relationships (SARs)

2018 ◽  
Vol 44 (12) ◽  
pp. 7491-7507 ◽  
Author(s):  
Guda Mallikarjuna Reddy ◽  
Gundala Sravya ◽  
Gutha Yuvaraja ◽  
Alexandre Camilo ◽  
Grigory V. Zyryanov ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Simulation Studies ◽  
Structure Activity Relationships ◽  
Structure Activity

Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships

2021 ◽  
Vol 21 ◽  
Author(s):  
Kong Zhang ◽  
Tianze Li ◽  
Xijie Shan ◽  
Rongfei Lu ◽  
Shaoyong Zhang ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Anticancer Activity ◽  
Structural Modification ◽  
Biological Properties ◽  
Mechanisms Of Action ◽  
Inflammatory Activity ◽  
Anti Psychotic ◽  
Structure Activity Relationships ◽  
Structure Activity

: Cholesterol, a steroid alcohol, was discovered by M.E. Chevreul in 1815. Cholesterol and its derivatives showed a large variety of biological properties such as anticancer activity, anticardiac activity, anti-inflammatory activity, antimicrobial activity, anti-psychotic activity, antioxidant activity, drug-loaded activity, etc. In this mini-review, the advances of structural modification of cholesterol from 2014 to 2020 were summarized. In addition, the bioactivities, mechanisms of action and structure-activity relationships of cholesterol and its related derivatives were involved.

scholarly journals Antimicrobial Properties of Volatile Phenylpropanes

2010 ◽  
Vol 5 (9) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Alexander Pauli ◽  
Karl-Heinz Kubeczka
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Properties ◽  
Substitution Pattern ◽  
Structure Activity Relationships ◽  
Specific Effects ◽  
Structure Activity ◽  
Microbial Characteristics ◽  
Cis And Trans Isomers ◽  
Species Specific ◽  
Cis And Trans

The examination of antimicrobial structure-activity relationships of 93 volatile phenylpropanes (VPs) and 21 related aromatic compounds revealed a dependence of antimicrobial activity from the kind and number of substituents on the aromatic ring, their substitution pattern and microbial characteristics, such as Gram coloring and strain specific factors. Eugenol isomers were predominantly inhibitory in a concentration range from 25 to 2000 mg/L against all microorganisms tested, which were three strains of Escherichia Coli and Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Listeria monocytogenes, and Candida albicans. Etherified VPs were either less active or inactive depending on the type of side chain and/or substitution pattern. Differences in the antimicrobial activity of cis- and trans-isomers were observed. Species specific structure-activity relationships exist as was demonstrated with the Gram-negative bacteria (inactivity of E-ortho-eugenol) C. albicans (activity of di- and threefold methoxylated 1-propenylbenzenes), S. aureus and B. subtilis (activity of di-ortho methoxylated phenolic allylbenzenes and hydroquinone derivatives). With regard to the variety of observed specific effects and natural variation of susceptibility towards VPs according to literature reference data, the chances for successful prediction by computational analysis (QSAR) appear to be limited.

1,5-Benzodiazepine derivatives as potential antimicrobial agents: design, synthesis, biological evaluation, and structure–activity relationships

2015 ◽  
Vol 13 (19) ◽  
pp. 5497-5509 ◽  
Author(s):  
Lan-Zhi Wang ◽  
Xiao-Qing Li ◽  
Ying-Shuang An
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Benzodiazepine Derivatives

36 novel 1,5-benzodiazepine derivatives were synthesized and evaluated for their in vitro antimicrobial activity. The results revealed that most of the 1,5-benzodiazepine derivatives exhibited considerable potency against all of the tested strains.

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