scholarly journals Study of cytotoxic activity of Ti–13Nb–13Zr medical alloy with different surface finishing techniques

2021 ◽  
Author(s):  
Viktoria Hoppe ◽  
Patrycja Szymczyk-Ziółkowska ◽  
Małgorzata Rusińska ◽  
Dominik Poradowski ◽  
Maciej Janeczek ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Chemical Characterization ◽  
Surface Finishing ◽  
Laser Confocal Scanning Microscopy ◽  
Scale Levels ◽  
Confocal Scanning ◽  
Characterization Of Materials ◽  
New Generation

AbstractThe characterization of materials surface is essential, as the initial in vivo response is highly dependent on surface properties. Surface topography is a key aspect that influences the response of cells to products resulting from interaction with the surface of a titanium alloy, including parameters such as adhesion, spread, migration, proliferation, and differentiation of cells. Various surface modifications are used to improve the interface properties between MC3T3 and NHDF cells and the Ti–13Nb–13Zr-based surface. Among the techniques discussed in this paper, scanning electron microscopy, laser confocal scanning microscopy, and computed tomography are adequate to investigate materials topography at different scale levels. Chemical characterization of the outer layers of Ti–13Nb–13Zr samples was performed with X-ray photoelectron spectrometry. Studies have shown that the surfaces resulting from the treatment enabling the formation of titanium oxide and zirconium oxide show the lowest cytotoxicity. Implants made from the new generation of titanium alloy, not containing toxic elements, with the use of surface modification could be an essential innovation in implantology.

Radiological and physico-chemical characterization of materials from phosphoric acid production plant to assess the workers radiological risks

Chemosphere ◽  
2020 ◽  
Vol 253 ◽  
pp. 126682
Author(s):  
J.L. Guerrero ◽  
S.M. Pérez-Moreno ◽  
F. Mosqueda ◽  
M.J. Gázquez ◽  
J.P. Bolívar
Keyword(s):  
Phosphoric Acid ◽  
Acid Production ◽  
Chemical Characterization ◽  
Production Plant ◽  
Physico Chemical ◽  
Characterization Of Materials

Chemical Characterization of a Procyanidin-Rich Extract from Sorghum Bran and Its Effect on Oxidative Stress and Tumor Inhibition in Vivo

2011 ◽  
Vol 59 (16) ◽  
pp. 8609-8615 ◽  
Author(s):  
Li Wu ◽  
Zhaohui Huang ◽  
Peiyou Qin ◽  
Yang Yao ◽  
Xianjun Meng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chemical Characterization ◽  
Tumor Inhibition ◽  
Sorghum Bran

scholarly journals Chemical Characterization of the Lichen-symbiont Microalga Asterochloris erici and Study of Its Cytostatic Effect on the L929 Murine Fibrosarcoma Cell Line

2021 ◽  
Author(s):  
M. Concepción Matesanz ◽  
Mercedes Villa-Carvajal ◽  
Javier Linares ◽  
Sonia Morante-Zarcero ◽  
Isabel Sierra ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Chemical Characterization ◽  
Human Consumption ◽  
Cytostatic Effect ◽  
In Vitro Biocompatibility ◽  
Murine Fibrosarcoma ◽  
Terrestrial Lichen

New resources of food, pharmaceuticals or biotechnological products are needed. The huge biodiversity of aero-terrestrial lichen-symbiont microalgae remains unexplored. Viability of these for human consumption demands the demonstration of the absence of toxic effects. In vitro biocompatibility of crude homogenates of axenic microalga Asterochloris erici, symbiotic in the lichen Cladonia cristatella, was analyzed after treatment of cultured L929 fibroblasts with different doses of microalgal homogenates. The results show that crude homogenates of A. erici do not induce fibroblast cytotoxicity but seem to have some cytostatic effect inducing slight cell cycle alterations and intracellular reactive oxygen species (ROS) increase at the highest dose. Carotenoid analysis demonstrates high content of lutein, a xanthophyll with antioxidant and cytostatic properties in vivo. These findings confirm that Asterochloris erici can be considered suitable for the development of alimentary or pharmaceutical applications. The cytostatic effects should be further investigated for antitumor agents.

Chemical characterization of bioactive peptides from in vivo digests of casein

1989 ◽  
Vol 56 (3) ◽  
pp. 343-349 ◽  
Author(s):  
Hans Meisel ◽  
Herman Frister
Keyword(s):  
Trace Elements ◽  
Bioactive Peptides ◽  
Binding Assay ◽  
Chemical Characterization ◽  
Opiate Receptor ◽  
Opioid Peptide ◽  
Biologically Active ◽  
Opioid Activity

SummaryThe in vivo formation of biologically active caseinopeptides was studied. It was proved that bioactive peptides were released in the small intestine of minipigs in the course of luminal digestion of diets containing bovine casein. An opioid peptide and a phosphopeptide were isolated from jejunal chyme and were chemically characterized. The opioid peptide has been identified as a fragment of β-casein (60–70). This peptide, named β-casomorphin-ll, displayed substantial opioid activity in an opiate receptor-binding assay. The caseinophosphopeptide has been shown to be a fragment of αs1-casein (66–74). Casein-derived phosphopeptides exhibit a potent ability to form soluble complexes with Ca and trace elements. Evidence exists that casomorphins and caseinophosphopeptides participate in the regulation of nutrient entry.

Chemical Characterization and In Vivo Anti-Inflammatory Activities of Actinidia callosa var. ephippioides via Suppression of Proinflammatory Cytokines

2013 ◽  
Vol 41 (02) ◽  
pp. 405-423 ◽  
Author(s):  
Jung-Chun Liao ◽  
Shyh-Shyun Huang ◽  
Jeng-Shyan Deng ◽  
Chao-Ying Lee ◽  
Ying-Chih Lin ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Ethyl Acetate Fraction ◽  
Paw Edema ◽  
Inflammatory Mechanism ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Factor Α ◽  
Oxide Synthase

Actinidia callosa var. ephippioides (ACE) has been widely used to treat anti-pyretic, antinociceptive, anti-inflammation, abdominal pain and fever in Taiwan. This study aims to determine the mechanism of anti-inflammatory activities of ethyl acetate fraction of ACE (EA-ACE) using a model of λ-carrageenan (Carr)-induced paw edema in mouse model. In HPLC analysis, chemical characterization of EA-ACE was established. In order to investigate the anti-inflammatory mechanism of EA-ACE, we have detected the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and the levels of malondialdehyde (MDA) in the paw edema. Serum NO, tumor necrosis factor α (TNF-α), and interleukin-1β (IL-1β) were evaluated. Chemical characterization from HPLC indicated that EA-ACE contains betulinic acid, ursolic acid and oleanolic acid. In the anti-inflammatory test, EA-ACE decreased the paw edema after Carr administration, increased the activities of CAT, SOD, and GPx and decreased the MDA level in the edema paw at the 5th hr after Carr injection. EA-ACE affects the serum NO, TNF-α, and IL-1β levels at the 5th hr after Carr injection. EA-ACE decreased Carr-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions by Western blotting. Actinidia callosa var. ephippioides have the potential to provide a therapeutic approach to inflammation-associated disorders.

New Method for (Nano)Micro-Characterization of Materials - Correlative Microscopy

2014 ◽  
Vol 1000 ◽  
pp. 265-268
Author(s):  
Jaromír Wasserbauer ◽  
Martin Zmrzlý
Keyword(s):  
Building Materials ◽  
Chemical Characterization ◽  
Material Distribution ◽  
Correlative Microscopy ◽  
Materials Analysis ◽  
Characterization Of Materials ◽  
Alkali Activated Concrete ◽  
Alkali Activated ◽  
Scanning Electron

New building materials must meet strict requirements on mechanical properties. Therefore structural and chemical characterization of new building materials is very important. The correlative microscopy is a new possibility of materials analysis. This method combines light microscopy (LM) and scanning electron microscopy (SEM). LM images can be then precisely extended by their morphological background and/or material distribution, e.g. with energy dispersive spectroscopy (EDS). With using correlative microscopy, the weakest places of alkali-activated concrete were found.

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