Antibiotic-loaded chitosan–Laponite films for local drug delivery by titanium implants: cell proliferation and drug release studies

2015 ◽  
Vol 26 (12) ◽  
Author(s):  
Farideh Ordikhani ◽  
Mehdi Dehghani ◽  
Arash Simchi
Keyword(s):  
Drug Delivery ◽  
Cell Proliferation ◽  
Drug Release ◽  
Titanium Implants ◽  
Local Drug Delivery ◽  
Release Studies

scholarly journals Formulation and characterization of flurbiprofen loaded microsponge based gel for sustained drug delivery

2019 ◽  
Vol 10 (4) ◽  
pp. 2765-2776
Author(s):  
Naresh Kshirasagar ◽  
Goverdhan Puchchakayala ◽  
Balamurgan K
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Diffusion Method ◽  
Skin Delivery ◽  
Sustained Action ◽  
Release Studies ◽  
Ft Ir ◽  
Polymer Ratio

The new investigation in this present work is to develop microsponges constructed novel drug delivery system for sustained action of Flurbiprofen. Quai-emulsion solvent diffusion method was engaged using Ethyl cellulose and Eudragit RS100 with drug: polymer ratio for development of microsponges. For optimization purposes, several factors are considered in the investigation. Several evaluation studies for the formed microsponges were carried out FT-IR, SEM, DSC, X-RD, particle size analysis, morphology, drug loading and In vitro drug release studies were carried out. Finally, it was concluded that there is no drug-polymer interaction as per DSC & FT-IR. Encapsulation efficiency, particle size and drug content showed a higher impact on alteration of drug-polymer ratio. SEM studies showed that morphological microsponges are spherical and porous in nature and with the mean particle size of 38.86 μm. The gel loaded with microsponges, were followed by In vitro and Ex vivo drug release studies by modified Franz diffusion cell. Skin delivery of optimized formulation enhanced the drug residence time and maintained therapeutic concentration for an extended period of time, which is possible to show sustained action of the drug.

scholarly journals Monitoring of Antimicrobial Drug Chloramphenicol Release from Electrospun Nano- and Microfiber Mats using UV Imaging and Bacterial Bioreporters

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 487 ◽  
Author(s):  
Preem ◽  
Bock ◽  
Hinnu ◽  
Putrinš ◽  
Sagor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Bacterial Infections ◽  
High Performance ◽  
Model Systems ◽  
Local Drug Delivery ◽  
Imaging Method ◽  
Release Behavior ◽  
Buffer Solution ◽  
Uv Imaging

New strategies are continuously sought for the treatment of skin and wound infections due to increased problems with non-healing wounds. Electrospun nanofiber mats with antibacterial agents as drug delivery systems provide opportunities for the eradication of bacterial infections as well as wound healing. Antibacterial activities of such mats are directly linked with their drug release behavior. Traditional pharmacopoeial drug release testing settings are not always suitable for analyzing the release behavior of fiber mats intended for the local drug delivery. We tested and compared different drug release model systems for the previously characterized electrospun chloramphenicol (CAM)-loaded nanofiber (polycaprolactone (PCL)) and microfiber (PCL in combination with polyethylene oxide) mats with different drug release profiles. Drug release into buffer solution and hydrogel was investigated and drug concentration was determined using either high-performance liquid chromatography, ultraviolet-visible spectrophotometry, or ultraviolet (UV) imaging. The CAM release and its antibacterial effects in disc diffusion assay were assessed by bacterial bioreporters. All tested model systems enabled to study the drug release from electrospun mats. It was found that the release into buffer solution showed larger differences in the drug release rate between differently designed mats compared to the hydrogel release tests. The UV imaging method provided an insight into the interactions with an agarose hydrogel mimicking wound tissue, thus giving us information about early drug release from the mat. Bacterial bioreporters showed clear correlations between the drug release into gel and antibacterial activity of the electrospun CAM-loaded mats.

Fabrication of Vesicular Drug Delivery of Niosomal Topical Formulation for the Effective Treatment of Osteoarthritis

2016 ◽  
Vol 12 ◽  
pp. 1-8
Author(s):  
S. Nagalakshmi ◽  
T. Sandeep ◽  
S. Shanmuganathan
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Methyl Cellulose ◽  
Entrapment Efficiency ◽  
Lipid Vesicles ◽  
Tween 20 ◽  
Injection Method ◽  
Topical Gel ◽  
Release Studies

Delivery of drug through topical route, delivers most convenient and novel approach. The Skin can offer several advantages as a route of drug administration although its barrier nature makes it difficult for most drugs to penetrate in to and permeate through it. During the past decades there has been a lot of interest in lipid vesicles as a tool to improve topical drug delivery. Vesicular system such as liposomes, niosomes, ethosomes and elastic deformable vesicles provide an alternative for improved skin drug delivery. In fact vesicles can act as drug carriers controlling drug release. The Research findings were intended to develop sustained release of aceclofenac niosomes formulations in order to reduce gastrointestinal disturbances and to provide better effect when applied topically. Niosomes of aceclofenac was prepared by modified ether injection method using different ratio of surfactants (Tween 20, 40, 60 & 80) with cholesterol and drug. The developed formulations were optimized based on the high entrapment efficiency and in-vitro release studies. Optimized batch was selected and made in to topical niosomal gel using gelling agents like carbopol and sodium carboxy methyl cellulose. Formulation were evaluated for various parameters like vesicle shape, vesicle size, entrapment efficiency, drug content, compatibility studies, in-vitro release studies and stability studies. Ether injection method was found to be most satisfactory in terms of niosome particle size, drug entrapment efficiency was found to be 88.68 ±0.64 % and in-vitro release studies showed 40% of sustain drug release at the end of 8 hrs of study when compared with marketed formulation. Hence, the formulated niosomal topical gel was found to be a better alternative when compared to the marketed formulation in terms of better efficacy, bioavailability and permeation.

scholarly journals A Review of Sustained Drug Release Studies from Nanofiber Hydrogels

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1612
Author(s):  
Ilker S. Bayer
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cell Function ◽  
High Surface ◽  
Polymer Networks ◽  
Cellular Interactions ◽  
Sustained Drug Release ◽  
Sustained Drug Delivery ◽  
Recent Advances ◽  
Release Studies

Polymer nanofibers have exceptionally high surface area. This is advantageous compared to bulk polymeric structures, as nanofibrils increase the area over which materials can be transported into and out of a system, via diffusion and active transport. On the other hand, since hydrogels possess a degree of flexibility very similar to natural tissue, due to their significant water content, hydrogels made from natural or biodegradable macromolecular systems can even be injectable into the human body. Due to unique interactions with water, hydrogel transport properties can be easily modified and tailored. As a result, combining nanofibers with hydrogels would truly advance biomedical applications of hydrogels, particularly in the area of sustained drug delivery. In fact, certain nanofiber networks can be transformed into hydrogels directly without the need for a hydrogel enclosure. This review discusses recent advances in the fabrication and application of biomedical nanofiber hydrogels with a strong emphasis on drug release. Most of the drug release studies and recent advances have so far focused on self-gelling nanofiber systems made from peptides or other natural proteins loaded with cancer drugs. Secondly, polysaccharide nanofiber hydrogels are being investigated, and thirdly, electrospun biodegradable polymer networks embedded in polysaccharide-based hydrogels are becoming increasingly popular. This review shows that a major outcome from these works is that nanofiber hydrogels can maintain drug release rates exceeding a few days, even extending into months, which is an extremely difficult task to achieve without the nanofiber texture. This review also demonstrates that some publications still lack careful rheological studies on nanofiber hydrogels; however, rheological properties of hydrogels can influence cell function, mechano-transduction, and cellular interactions such as growth, migration, adhesion, proliferation, differentiation, and morphology. Nanofiber hydrogel rheology becomes even more critical for 3D or 4D printable systems that should maintain sustained drug delivery rates.

scholarly journals Influence of sterilization on the drug release behaviour of drug coated silicone

2021 ◽  
Vol 7 (2) ◽  
pp. 672-675
Author(s):  
Katharina Wulf ◽  
Stefan Raggl ◽  
Thomas Eickner ◽  
Gerrit Paasche ◽  
Niels Grabow
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Polymer Coating ◽  
Drug Loading ◽  
In Vitro Release ◽  
Physical Chemical ◽  
Release Studies ◽  
Vitro Release ◽  
Dual Drug

Abstract Sterilization processes ensure sterility of drug delivery systems, but may negatively affect the properties of biomaterials and incorporated drugs by changing their physical, chemical, mechanical properties and drug release behaviour. Therefore, it is important to investigate their influence. In this study, the influence of ethylene oxide (EtO) sterilization on the drug loading and release behaviour of incorporated Diclofenac (DCF) in a Poly-L-lactide (PLLA) coating and Dexamethasone (DMS) in the silicone carrier is presented. Silicone samples containing DMS were coated with PLLA containing DCF varying in layer thickness (5, 10, and 20 μm). Half of the samples underwent EtO sterilization, the other half was not sterilized. All un-/sterilized sample surfaces were in view of the morphology and hydrophilicity examined. Furthermore, in vitro release studies of DMS and DCF were conducted. The sterilized sample surfaces showed no morphological and hydrophilicity changes. The DCF and DMS loadings were similar for the sterile and untreated samples. This also applied to the in vitro DMS release profiles apart from the end of the studies where slight differences were evident. The results indicate that both drugs loaded in the polymer coating and the silicone were not impaired by the sterilization process. Thus, EtO sterilization appears suitable for DMS containing silicone and DCF incorporated PLLA coatings as a dual drug delivery system.

scholarly journals Stimulus-responsive liquids for encapsulation storage and controlled release of drugs from nano-shell capsules

2010 ◽  
Vol 8 (56) ◽  
pp. 451-456 ◽  
Author(s):  
Ming-Wei Chang ◽  
Eleanor Stride ◽  
Mohan Edirisinghe
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Polymeric Materials ◽  
Controlled Drug Release ◽  
Ambient Conditions ◽  
Smart Polymer ◽  
Release Studies ◽  
Stimulus Responsive ◽  
New Strategy

Drug-delivery systems with a unique capability to respond to a given stimulus can improve therapeutic efficacy. However, development of such systems is currently heavily reliant on responsive polymeric materials and pursuing this singular strategy limits the potential for clinical translation. In this report, with a model system used for drug-release studies, we demonstrate a new strategy: how a temperature-responsive non-toxic, volatile liquid can be encapsulated and stored under ambient conditions and subsequently programmed for controlled drug release without relying on a smart polymer. When the stimulus temperature is reached, controlled encapsulation of different amounts of dye in the capsules is achieved and facilitates subsequent sustained release. With different ratios of the liquid (perfluorohexane): dye in the capsules, enhanced controlled release with real-time response is provided. Hence, our findings offer great potential for drug-delivery applications and provide new generic insights into the development of stimuli drug-release systems.

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