The relationship between resting blood pressure and acute pain sensitivity: effects of chronic pain and alpha-2 adrenergic blockade

2007 ◽  
Vol 31 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Stephen Bruehl ◽  
Ok Y. Chung ◽  
Laura Diedrich ◽  
André Diedrich ◽  
David Robertson
Keyword(s):  
Blood Pressure ◽  
Chronic Pain ◽  
Acute Pain ◽  
Pain Sensitivity ◽  
Adrenergic Blockade ◽  
Resting Blood Pressure ◽  
The Relationship

Blood pressure control in pregnant rabbits: norepinephrine and prostaglandin interactions

1984 ◽  
Vol 247 (5) ◽  
pp. R786-R791 ◽  
Author(s):  
R. Venuto ◽  
I. Min ◽  
P. Barone ◽  
A. Donker ◽  
E. Cunningham
Keyword(s):  
Blood Pressure ◽  
Pressor Response ◽  
Pressure Control ◽  
Systemic Blood Pressure ◽  
Blood Levels ◽  
Adrenergic Blockade ◽  
Resting Blood Pressure ◽  
Pge2 Concentration ◽  
The Relationship ◽  
Hypotensive Response

The relationship between norepinephrine (NE) and prostaglandins in the regulation of systemic blood pressure during pregnancy was examined in conscious rabbits. The arterial prostaglandin E2 (PGE2) concentration was higher in pregnant than in nonpregnant rabbits. Resting blood pressure was slightly lower in the gravid animals. The pressor response to incremental doses of intravenous NE was blunted in the pregnant rabbits. Meclofenamate, a cyclooxygenase inhibitor, failed to alter the resting blood pressure in either group of animals, although it reduced PGE2 levels more than 60% in the pregnant rabbits. The pressor response to NE was significantly increased only in the pregnant rabbits when the NE infusion was repeated following meclofenamate. Pregnant rabbits could also be differentiated from nonpregnant by their higher peripheral blood levels of NE and their uniform hypotensive response to alpha-adrenergic blockade. These observations define an altered responsiveness to both endogenous and exogenous NE in pregnant rabbits that appears to be related to an increase in vasodilator prostaglandins.

Gender Differences in Pain Sensitivity and Resting Blood Pressure

2010 ◽  
Author(s):  
Suzanne G. Helfer ◽  
Ashley D. Bugeja ◽  
Sarah E. Jackson ◽  
Elizabeth Woltja
Keyword(s):  
Blood Pressure ◽  
Gender Differences ◽  
Pain Sensitivity ◽  
Resting Blood Pressure

System-Justifying Beliefs Moderate the Relationship Between Perceived Discrimination and Resting Blood Pressure

2011 ◽  
Vol 29 (3) ◽  
pp. 303-321 ◽  
Author(s):  
Dina Eliezer ◽  
Sarah S. M. Townsend ◽  
Pamela J. Sawyer ◽  
Brenda Major ◽  
Wendy Berry Mendes
Keyword(s):  
Blood Pressure ◽  
Perceived Discrimination ◽  
Resting Blood Pressure ◽  
The Relationship

scholarly journals The effects of propranolol on heart rate variability and quantitative, mechanistic, pain profiling: a randomized placebo-controlled crossover study

2018 ◽  
Vol 18 (3) ◽  
pp. 479-489 ◽  
Author(s):  
Kristian Kjær Petersen ◽  
Hjalte Holm Andersen ◽  
Masato Tsukamoto ◽  
Lincoln Tracy ◽  
Julian Koenig ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Chronic Pain ◽  
Pain Sensitivity ◽  
Experimental Pain ◽  
Central Pain ◽  
Healthy Male ◽  
Pain Pathways ◽  
Β Blocker ◽  
Chronic Pain Conditions

AbstractBackground and aimsThe autonomic nervous system (ANS) is capable of modulating pain. Aberrations in heart rate variability (HRV), reflective of ANS activity, are associated with experimental pain sensitivity, chronic pain, and more recently, pain modulatory mechanisms but the underlying mechanisms are still unclear. HRV is lowered during experimental pain as well as in chronic pain conditions and HRV can be increased by propranolol, which is a non-selective β-blocker. Sensitization of central pain pathways have been observed in several chronic pain conditions and human mechanistic pain biomarkers for these central pain pathways include temporal summation of pain (TSP) and conditioned pain modulation (CPM). The current study aimed to investigate the effect of the β-blocker propranolol, and subsequently assessing the response to standardized, quantitative, mechanistic pain biomarkers.MethodsIn this placebo-controlled, double-blinded, randomized crossover study, 25 healthy male volunteers (mean age 25.6 years) were randomized to receive 40 mg propranolol and 40 mg placebo. Heart rate, blood pressure, and HRV were assessed before and during experimental pain tests. Cuff pressure pain stimulation was used for assessment of pain detection (cPDTs) and pain tolerance (cPTTs) thresholds, TSP, and CPM. Offset analgesia (OA) was assessed using heat stimulation.ResultsPropranolol significantly reduced heart rate (p<0.001), blood pressure (p<0.02) and increased HRV (p<0.01) compared with placebo. No significant differences were found comparing cPDT (p>0.70), cPTT (p>0.93), TSP (p>0.70), OA-effect (p>0.87) or CPM (p>0.65) between propranolol and placebo.ConclusionsThe current study demonstrated that propranolol increased HRV, but did not affect pressure pain sensitivity or any pain facilitatory or modulatory outcomes.ImplicationsAnalgesic effects of propranolol have been reported in clinical pain populations and the results from the current study could indicate that increased HRV from propranolol is not associated with peripheral and central pain pathways in healthy male subjects.

Health Related Fitness and Blood Pressure in Boys and Girls Ages 10 to 17 Years

1992 ◽  
Vol 4 (2) ◽  
pp. 128-135 ◽  
Author(s):  
Carmelo Bazzano ◽  
Lee N. Cunningham ◽  
Giustino Varrassi ◽  
Tony Falconio
Keyword(s):  
Blood Pressure ◽  
Body Composition ◽  
Aerobic Fitness ◽  
School System ◽  
Physical Fitness Test ◽  
Test Items ◽  
Resting Blood Pressure ◽  
Health Related ◽  
Criterion Referenced ◽  
The Relationship

The present study examined the relationships among the AAHPERD Physical Best health related physical fitness test (HRPFT) items to resting blood pressure in 80 boys and 84 girls from the Lanciano, Italy, school system. Systolic blood pressure (SBP) was significantly associated with age for both sexes. Diastolic blood pressure (DBP) for boys was found to be associated with fatness when age was held constant. To examine the relationship between blood pressure and the HRPFT, data were sorted into two groups of students passing or failing to meet the criterion-referenced standard (CRS) by 1-mile run performance and sum of skinfolds. SBP did not differ significantly between groups for either sex. Boys who failed to meet the CRS for 1-mile run performance showed a higher DBP of 4 mmHg when compared to boys who achieved the CRS. The group passing the aerobic fitness and body composition tests tended to perform better on all test items. With the possible exception of DBP for boys, it is concluded that performance on the Physical Best HRPFT is not associated with resting blood pressure in children and adolescents.

ACE I/D Genotype, Habitual Physical Activity, and Blood Pressure in Children

2010 ◽  
Vol 22 (2) ◽  
pp. 301-313 ◽  
Author(s):  
Mark A. Sarzynski ◽  
Joey C. Eisenmann ◽  
Gregory J. Welk ◽  
Jared Tucker ◽  
Kim Glenn ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Vigorous Physical Activity ◽  
Lower Body ◽  
Converting Enzyme ◽  
Resting Blood Pressure ◽  
Female Children ◽  
Partial Correlations ◽  
Ace Genotype ◽  
The Relationship

The present study examined the association between the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism, physical activity, and resting blood pressure (BP) in a sample of 132 children (48.4% female). Children attaining 60 min/day of moderate-to-vigorous physical activity (MVPA) possessed lower % body fat (29% vs 24%, p < .05). Resting BP did not significantly differ between genotypes. Furthermore, partial correlations between MVPA and BP were low and did not vary by ACE genotype. Thus, the ACE I/D genotype is not associated with BP and does not modify the relationship between physical activity and BP in this sample of children.

Sign in / Sign up

Export Citation Format

Share Document