ACE I/D Genotype, Habitual Physical Activity, and Blood Pressure in Children

2010 ◽  
Vol 22 (2) ◽  
pp. 301-313 ◽  
Author(s):  
Mark A. Sarzynski ◽  
Joey C. Eisenmann ◽  
Gregory J. Welk ◽  
Jared Tucker ◽  
Kim Glenn ◽  
...  

The present study examined the association between the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism, physical activity, and resting blood pressure (BP) in a sample of 132 children (48.4% female). Children attaining 60 min/day of moderate-to-vigorous physical activity (MVPA) possessed lower % body fat (29% vs 24%, p < .05). Resting BP did not significantly differ between genotypes. Furthermore, partial correlations between MVPA and BP were low and did not vary by ACE genotype. Thus, the ACE I/D genotype is not associated with BP and does not modify the relationship between physical activity and BP in this sample of children.

2010 ◽  
Vol 22 (3) ◽  
pp. 369-378 ◽  
Author(s):  
Joey C. Eisenman ◽  
Mark A. Sarzynski ◽  
Jerod Tucker ◽  
Kate A. Heelan

The purpose of this study was to examine if offspring physical activity may affect the relationship between maternal overweight and offspring fatness and blood pressure (BP). Subjects included 144 maternal-child pairs (n = 74 boys and 70 girls, mean age = 7.3 yrs). Maternal prepregnancy BMI was determined by self-report. Offspring characteristics included resting systolic and diastolic BP, body fatness by dual energy x-ray absorbtiometry, and moderate-to-vigorous physical activity (MVPA) using the Actigraph accelerometer. Children whose mothers were overweight or obese prepregnancy (Prepreg OW) were significantly larger and fatter than children from mothers with a normal prepregnancy BMI (Prepreg NORM). Prepreg OW children also had higher mean arterial pressure than Prepreg NORM children. BP values were not different across maternal Prepreg BMI/MVPA groups. Percent fat was significantly different across Prepreg BMI/MVPA groups. Prepreg OW children that did not meet the daily recommended value of MVPA were the fattest. Prepreg OW children that attained 360 min of MVPA/day had a mean percent body fat that was similar to Prepreg NORM children of either MVPA group.


2014 ◽  
Vol 26 (3) ◽  
pp. 221-230 ◽  
Author(s):  
Katrina D. DuBose ◽  
Andrew J. McKune

The relationship between physical activity levels, salivary cortisol, and the metabolic syndrome (MetSyn) score was examined. Twenty-three girls (8.4 ± 0.9 years) had a fasting blood draw, waist circumference and blood pressure measured, and wore an ActiGraph accelerometer for 5 days. Saliva samples were collected to measure cortisol levels. Previously established cut points estimated the minutes spent in moderate, vigorous, and moderate-to-vigorous physical activity. A continuous MetSyn score was created from blood pressure, waist circumference, high-density-lipoprotein (HDL), triglyceride, and glucose values. Correlation analyses examined associations between physical activity, cortisol, the MetSyn score, and its related components. Regression analysis examined the relationship between cortisol, the MetSyn score, and its related components adjusting for physical activity, percent body fat, and sexual maturity. Vigorous physical activity was positively related with 30 min post waking cortisol values. The MetSyn score was not related with cortisol values after controlling for confounders. In contrast, HDL was negatively related with 30 min post waking cortisol. Triglyceride was positively related with 30 min post waking cortisol and area under the curve. The MetSyn score and many of its components were not related to cortisol salivary levels even after adjusting for physical activity, body fat percentage, and sexual maturity.


2003 ◽  
Vol 28 (5) ◽  
pp. 699-709 ◽  
Author(s):  
Catrine Tudor-Locke ◽  
Barbara E. Ainsworth ◽  
Melicia C. Whitt ◽  
Raymond W. Thompson ◽  
Cheryl L. Addy ◽  
...  

The purpose of this study was to explore the relationship between objectively determined ambulatory activity and simple cardiorespiratory parameters (heart rate and blood pressure at rest and during submaximal exercise) in individuals who were stratified for self-reported participation (yes/any vs. no/none) in vigorous physical activity (PA). Ninety-eight subjects (African Americans: 7 M, 16 F; Caucasians: 33 M, 42 F; mean age 46.4 ± 15.4 yrs; mean BMI 26.7 ± 4.8) wore a pedometer for 21 consecutive days and completed a 10-min submaximal treadmill graded exercise test with HR (beats/min) and BP (mmHg) measured while walking at 4.8 km/hr and a 10% grade. Subjects averaged 7,618 ± 3,045 steps/day. There were no differences in steps/day by self-reported vigorous PA strata. There was an inverse relationship (r = −0.35, p = 0.03) between steps/day and resting HR in subjects who reported no vigorous PA. There was an inverse relationship (r = −0.22, p = 0.04) between steps/day and submaximal HR in all subjects. When stratified for self-reported vigorous PA, the inverse relationship between steps/day and submaximal HR was stronger for those reporting no vigorous PA (r = −0.39, p = 0.01) vs. those reporting any vigorous PA (r = 0.28, p = 0.05). There was no relationship between steps/day and BP at rest or during exercise in this normotensive sample. Key words: walking, blood pressure, heart rate


1999 ◽  
Vol 11 (3) ◽  
pp. 208-217 ◽  
Author(s):  
Joey C. Eisenmann ◽  
Peter T. Katzmarzyk ◽  
Germain Thériault ◽  
Thomas M.K. Song ◽  
Robert M. Malina ◽  
...  

The relationship between habitual physical activity and pulmonary function were considered in 424 boys and 366 girls, 9–18 years of age. Indicators of habitual physical activity were assessed using a 3-day activity diary and included estimated daily energy expenditure (EE) and time spent in moderate-to-vigorous physical activity (MVPA) (METs ≥ 4.8). Pulmonary function was measured according to standard procedures. Relationships were examined with partial correlations and ANCOVA, comparing the highest and lowest quartiles of EE and MVPA. When age and stature are statistically controlled, relationships between EE, MVPA, and pulmonary function was generally low and not significant, with the exception of FEV1% in 16–18-year-old girls (r ≤ −0.28). Youth in the highest and lowest quartiles of EE and MVPA do not differ in pulmonary function, except for PEER in 9–12-year-old boys, and FEV1% in 16–18-year-old boys, which are slightly greater (1–3%) in the less active group. These findings indicate that lung volumes, capacities, and flow rates are not consistently related to estimated habitual physical activity in a general, free-living population of youth.


2011 ◽  
Vol 23 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Heather M. Hayes ◽  
Joey C. Eisenmann ◽  
Kate A. Heelen ◽  
Greg J. Welk ◽  
Jared M. Tucker

The purpose of this study was to determine the joint association of fatness and physical activity on resting blood pressure in children. Subjects included 157 children (age 5.5–9.5 years). Moderate-to-vigorous physical activity (MVPA, min/day), body fatness, and resting blood pressure were measured. Four categories were created by cross tabulation of high/normal levels of fatness and high/low levels of MVPA. There were significant differences in systolic blood pressure and mean arterial pressure across the fat/MVPA groups (p < .05). Regardless of participating in an acceptable level of MVPA, overfat children had higher resting systolic blood pressure than normal fat children. MVPA did not significantly attenuate blood pressure within a fat category.


2017 ◽  
Vol 14 (11) ◽  
pp. 852-860 ◽  
Author(s):  
Emily Borgundvaag ◽  
Michael McIsaac ◽  
Michael M. Borghese ◽  
Ian Janssen

Background: A limitation of accelerometer measures of moderate to vigorous physical activity (MVPA) is nonwear time. Nonwear-time data is typically deleted prior to estimating MVPA. In this study, we used an approach that used sociodemographic, health, and time data to guide the imputation of nonwear-time data. We determined whether imputing nonwear-time data influences estimates of MVPA and the association between MVPA, body mass index, and blood pressure. Methods: Seven days of accelerometer data were collected on 332 children aged 10–13 years. MVPA was estimated in a “nonimputed dataset,” wherein nonwear-time data were deleted prior to estimating MVPA, and in an “imputed dataset,” wherein nonwear-time data were imputed using sociodemographic and health characteristics of participants and time characteristics of the nonwear period prior to estimating MVPA. Results: Nonwear time represented 7% of waking hours. Average MVPA estimates did not differ in the nonimputed and imputed datasets (56.8 vs 58.4 min/d). The strength of the relationship between MVPA and the 2 health outcomes did not differ in the nonimputed and imputed datasets. Conclusions: Studies achieving high accelerometer wear-time compliance can obtain MVPA estimates without substantial bias if they use the traditional approach of deleting nonwear-time data.


1994 ◽  
Vol 72 (01) ◽  
pp. 058-064 ◽  
Author(s):  
Goya Wannamethee ◽  
A Gerald Shaper

SummaryThe relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.


Author(s):  
Xiaoyong Xu ◽  
Xianghong Meng ◽  
Shin-ichi Oka

Abstract Objective Our work aimed to investigate the association between vigorous physical activity and visit-to-visit systolic blood pressure variability (BPV). Methods We conducted a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial), a well-characterized cohort of participants randomized to intensive (&lt;120 mmHg) or standard (&lt;140 mmHg) SBP targets. We assessed whether patients with hypertension who habitually engage in vigorous physical activity would have lower visit-to-visit systolic BPV compared with those who do not engage in vigorous physical activity. Visit-to-visit systolic BPV was calculated by standard deviation (SD), average real variability (ARV), and standard deviation independent of the mean (SDIM) using measurements taken during the 1-, 2-, 3-, 6-, 9- and 12-month study visits. A medical history questionnaire assessed vigorous physical activity, which was divided into three categories according to the frequency of vigorous physical activity. Results A total of 7571 participants were eligible for analysis (34.8% female, mean age 67.9±9.3 years). During a follow-up of 1-year, vigorous physical activity could significantly reduce SD, ARV, and SDIM across increasing frequency of vigorous physical activity. There were negative linear trends between frequency of vigorous physical activity and visit-to-visit systolic BPV. Conclusions Long-term engagement in vigorous physical activity was associated with lower visit-to-visit systolic BPV.


2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Lydia Q. Ong ◽  
John Bellettiere ◽  
Citlali Alvarado ◽  
Paul Chavez ◽  
Vincent Berardi

Abstract Background Prior research examining the relationship between cannabis use, sedentary behavior, and physical activity has generated conflicting findings, potentially due to biases in the self-reported measures used to assess physical activity. This study aimed to more precisely explore the relationship between cannabis use and sedentary behavior/physical activity using objective measures. Methods Data were obtained from the 2005–2006 National Health and Nutrition Examination Survey. A total of 2,092 participants (ages 20–59; 48.8% female) had accelerometer-measured sedentary behavior, light physical activity, and moderate-to-vigorous physical activity. Participants were classified as light, moderate, frequent, or non-current cannabis users depending on how often they used cannabis in the previous 30 days. Multivariable linear regression estimated minutes in sedentary behavior/physical activity by cannabis use status. Logistic regression modeled self-reported moderate-to-vigorous physical activity in relation to current cannabis use. Results Fully adjusted regression models indicated that current cannabis users’ accelerometer-measured sedentary behavior did not significantly differ from non-current users. Frequent cannabis users engaged in more physical activity than non-current users. Light cannabis users had greater odds of self-reporting physical activity compared to non-current users. Conclusions This study is the first to evaluate the relationship between cannabis use and accelerometer-measured sedentary behavior and physical activity. Such objective measures should be used in other cohorts to replicate our findings that cannabis use is associated with greater physical activity and not associated with sedentary behavior in order to fully assess the potential public health impact of increases in cannabis use.


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