Optimization of β-carotene loaded solid lipid nanoparticles preparation using a high shear homogenization technique

2008 ◽  
Vol 11 (3) ◽  
pp. 601-614 ◽  
Author(s):  
Michael D. Triplett ◽  
James F. Rathman
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
High Shear ◽  
Solid Lipid ◽  
Homogenization Technique ◽  
High Shear Homogenization ◽  
Β Carotene

scholarly journals Karakter Solid Lipid Nano Particle (SLN) – Ubiquinon (Q10) dengan Beda Jenis Kosurfaktan: Poloxamer 188, Lesitin, Propilen Glikol

2019 ◽  
Vol 6 (1) ◽  
pp. 17
Author(s):  
Noorma Rosita ◽  
Qurrotu A’yunin ◽  
Esti Hendradi
Keyword(s):  
Coenzyme Q10 ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
High Shear ◽  
Nano Particle ◽  
Poloxamer 188 ◽  
Solid Lipid ◽  
High Shear Homogenization

Pendahuluan: Ubiquinon atau Coenzyme Q10 (CoQ10) merupakan senyawa kimia yang tidak stabil terhadap cahaya, sehingga mudah terdegradasi. Oleh karena itu, sistem penghantaran yang bisa meningkatkan kestabilan dari CoQ10 sangat dibutuhkan. Solid lipid nanoparticles (SLN) diketahui mampu meningkatan stabilitas molekul, dan memiliki karakteristik pelepasan terkontrol. Karakteristik SLN (ukuran partikel dan efisiensi penjebakan obat), sangat dipengaruhi kompoen penyusun SLN. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui pengaruh perbedaan jenis kosurfaktan terhadap karakteristik SLN-CoQ10. SLN-CoQ10 dibuat dengan metode high shear homogenization pada kecepatan 24000 rpm selama 2 menit, 4 siklus. Metode: Pada penelitian ini dibuat empat formula SLN-CoQ10 dengan propilen glikol (A1), poloxamer 188 (B1), lesitin (C1) sebagai kosurfaktan dan pembanding tanpa kosurfaktan (D1). Hasil: Ukuran diameter partikel SLN-CoQ10 yang dihasilkan dari kosurfaktan propilen glikol, poloxamer 188, lesitin dan yang tanpa menggunakan surfaktan berturut-turut adalah: 556,1 ± 4,89; 174,1 ± 6,69; 220,4 ± 12,01 dan 556,8 ± 17,96 nm  sementara itu persen efisiensi penjebakan yang dihasilkan berturut-turut adalah 32,47 ± 6,88; 77,38 ± 8,63; 19,77 ± 5,69; dan 16,09 ± 3,70 %.  Kesimpulan: Berdasarkan hasil evaluasi karakteristik, disimpulkan bahwa SLN-CoQ10 yang dibuat dengan ko-surfaktan poloxamer 188 memiliki karakteristik yang paling baik karena memiliki ukuran partikel kecil dan persen efisiensi penjebakan yang paling besar dibandingkan dengan SLN-CoQ10 dengan formula yang menggunakan ko-surfaktan propilen glikol, lesitin atau yang tanpa kosurfaktan.

Development of Mupirocin- Tinidazole solid- Lipid Nanoparticles Loaded Topical gel for the Management of Bacterial Wound Infections

2021 ◽  
pp. 2785-2790
Author(s):  
Veintramuthusankar Veintramuthusankar ◽  
Pushparajudayakumar Pushparajudayakumar ◽  
Rajanduraibabyroselin Rajanduraibabyroselin
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Fickian Diffusion ◽  
Standard Drug ◽  
Topical Gel ◽  
Solid Lipid ◽  
Homogenization Technique ◽  
Significant Difference

Solid lipid nanoparticles (SLNs) are novel drug carrier system which consists of a solid matrix composed of a lipid being solid at both room and body temperatures with a mean Particle Size (PS) between 50 and 1000 nm Mupirocin -Tinidazole solid-lipid nanoparticles were prepared using hot homogenization technique using Glyceryl monosterate, Stearic acid, Tween 80 and Poloxamer 188 using hot homogenization technique. Size of the nanoparticles was in the range of 83 to 211 nm with the zeta potential values between -2.1 to -5.2. Atomic Force Microscopy (AFM) confirms the spherical shape of solid lipid nanoparticles. Entrapment efficiency was best in the F1 formulation. In vitro release of the pure drug was found to be 75% of mupirocin and 66.5% of tinidazole at the end of 1 hr. Drug release from SLNs dispersion followed Korsermeyrs peppas-model, indicating fickian diffusion drug release, while that from the gel followed non Fickian model drug release. Antibacterial activity of the SLNs was less but the SLNs based gel shows no significant difference in activity to that of standard drug gentamycin against aerobic bacteria. The SLNs dispersion exhibited physicochemical stability under refrigeration upto 45 days without significant difference in particle size. Best formulation was developed into a topical gel using sodium alginate and it was evaluated for pH, viscosity, spreadbility, extrudability, bloom strength, Minimum Inhibitory Concentration (MIC) and Methicillin resistant staphylococcus aureus (MRSA). Extrudability and spreadability parameters of the gel are similar to that of marketed Mupirocin 2% cream formulation

scholarly journals The lipid type affects the in vitro digestibility and β-carotene bioaccessibility of liquid or solid lipid nanoparticles

2020 ◽  
Vol 311 ◽  
pp. 126024 ◽  
Author(s):  
Heloísa Helena de Abreu-Martins ◽  
María Artiga-Artigas ◽  
Roberta Hilsdorf Piccoli ◽  
Olga Martín-Belloso ◽  
Laura Salvia-Trujillo
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vitro Digestibility ◽  
Solid Lipid ◽  
Β Carotene

Formulation and characterization of β‐carotene loaded solid lipid nanoparticles

2019 ◽  
Vol 43 (12) ◽  
Author(s):  
Sivakamasundari Selvakumar ◽  
Anu Bhushani Janakiraman ◽  
Maria Leena Michael ◽  
Moses Jeyan Arthur ◽  
Anandharamakrishnan Chinnaswamy
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Β Carotene

Stearyl ferulate-based solid lipid nanoparticles for the encapsulation and stabilization of β-carotene and α-tocopherol

2009 ◽  
Vol 72 (2) ◽  
pp. 181-187 ◽  
Author(s):  
Sonia Trombino ◽  
Roberta Cassano ◽  
Rita Muzzalupo ◽  
Attilio Pingitore ◽  
Erika Cione ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Β Carotene
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