Dietary Enrichment with Medium Chain Triglycerides (AC-1203) Elevates Polyunsaturated Fatty Acids in the Parietal Cortex of Aged Dogs: Implications for Treating Age-Related Cognitive Decline

2009 ◽  
Vol 34 (9) ◽  
pp. 1619-1625 ◽  
Author(s):  
Ameer Y. Taha ◽  
Samuel T. Henderson ◽  
W. M. Burnham
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Cognitive Decline ◽  
Parietal Cortex ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Age Related ◽  
Age Related Cognitive Decline

scholarly journals Randomized Trial of Marine n-3 Polyunsaturated Fatty Acids for the Prevention of Cerebral Small Vessel Disease and Inflammation in Aging (PUFA Trial): Rationale, Design and Baseline Results

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 735 ◽  
Author(s):  
Gene Bowman ◽  
Lisa Silbert ◽  
Hiroko Dodge ◽  
David Lahna ◽  
Kirsten Hagen ◽  
...  
Keyword(s):  
Older Adults ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Cognitive Decline ◽  
Small Vessel Disease ◽  
Controlled Trial ◽  
Cerebral White Matter ◽  
Operational Experience ◽  
Age Related ◽  
Age Related Cognitive Decline

Vascular risk factors for age-related cognitive decline are significant, and their management may ultimately prove the most successful strategy for reducing risk and sustaining cognitive health. This randomized, double-blinded, placebo-controlled trial with parallel group allocation to either marine n-3 polyunsaturated fatty acids (n-3 PUFA) or soybean oil placebo assesses the effects on the total volume of accumulation in cerebral white matter hyperintensities (WMH), a potentially modifiable neurovascular component of age-related cognitive decline. Total WMH accumulation over 3 years is the primary endpoint. The safety and efficacy of n-3 PUFA is evaluated in older adults with significant WMH and suboptimum plasma n-3 PUFA as inclusion criteria. One hundred and two non-demented older adults were enrolled with a mean age of 81.1 (±4.4) years, WMH of 19.4 (±16.1) cm3, and a plasma n-3 PUFA of 86.64 (±29.21) µg/mL. 61% were female, 28% were apolipoprotein E epsilon 4 carriers, and the mean mini-mental state exam (MMSE) was 27.9 (±1.7). This trial provides an initial evaluation of n-3 PUFA effects on WMH, a reproducible and valid risk biomarker for cognitive decline, as well as on inflammatory biomarkers thought to play a role in WMH accumulation. We present the baseline results and operational experience of enriching a study population on advanced age, blood n-3 PUFA, and magnetic resonance imaging (MRI) derived WMH with biomarker outcomes (WMH, inflammation markers) in a dementia prevention paradigm.

Dietary fatty acids, age-related cognitive decline, and mild cognitive impairment

2008 ◽  
Vol 12 (6) ◽  
pp. 382-386 ◽  
Author(s):  
V. Solfrizzi ◽  
C. Capurs ◽  
A. D’Introno ◽  
A. M. Colacicco ◽  
V. Frisardi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Dietary Fatty Acids ◽  
Age Related ◽  
Age Related Cognitive Decline

High monounsaturated fatty acids intake protects against age-related cognitive decline

Neurology ◽  
1999 ◽  
Vol 52 (8) ◽  
pp. 1563-1563 ◽  
Author(s):  
V. Solfrizzi ◽  
F. Panza ◽  
F. Torres ◽  
F. Mastroianni ◽  
A. Del Parigi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cognitive Decline ◽  
Monounsaturated Fatty Acids ◽  
Age Related ◽  
Age Related Cognitive Decline

The role of olive oil in Mediterranean diet: Unsaturated fatty acids protect from age-related cognitive decline

1997 ◽  
Vol 135 ◽  
pp. S3
Author(s):  
A. Capurso ◽  
V. Solfrizzi ◽  
F. Panza ◽  
F. Torres ◽  
F. Mastroianni ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cognitive Decline ◽  
Olive Oil ◽  
Mediterranean Diet ◽  
Unsaturated Fatty Acids ◽  
Age Related ◽  
Age Related Cognitive Decline

Dietary intake of unsaturated fatty acids and age-related cognitive decline: A 8.5-year follow-up of the Italian Longitudinal Study on Aging

2006 ◽  
Vol 27 (11) ◽  
pp. 1694-1704 ◽  
Author(s):  
Vincenzo Solfrizzi ◽  
Anna Maria Colacicco ◽  
Alessia D’Introno ◽  
Cristiano Capurso ◽  
Francesco Torres ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Longitudinal Study ◽  
Dietary Intake ◽  
Cognitive Decline ◽  
Unsaturated Fatty Acids ◽  
Age Related ◽  
Age Related Cognitive Decline

Activity Engagement in Cognitive Aging: A Review of the Evidence

2013 ◽  
Vol 23 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Yvonne Rogalski ◽  
Muriel Quintana
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Cognitive Aging ◽  
Social Activity ◽  
Current Evidence ◽  
Omega 3 ◽  
Neuroprotective Effects ◽  
Activity Engagement ◽  
Age Related ◽  
Age Related Cognitive Decline

The population of older adults is rapidly increasing, as is the number and type of products and interventions proposed to prevent or reduce the risk of age-related cognitive decline. Advocacy and prevention are part of the American Speech-Language-Hearing Association’s (ASHA’s) scope of practice documents, and speech-language pathologists must have basic awareness of the evidence contributing to healthy cognitive aging. In this article, we provide a brief overview outlining the evidence on activity engagement and its effects on cognition in older adults. We explore the current evidence around the activities of eating and drinking with a discussion on the potential benefits of omega-3 fatty acids, polyphenols, alcohol, and coffee. We investigate the evidence on the hypothesized neuroprotective effects of social activity, the evidence on computerized cognitive training, and the emerging behavioral and neuroimaging evidence on physical activity. We conclude that actively aging using a combination of several strategies may be our best line of defense against cognitive decline.

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