Albumin-Coated Porous Hollow Poly(Lactic-co-Glycolic Acid) Microparticles Bound with Palmityl-Acylated Exendin-4 as a Long-Acting Inhalation Delivery System for the Treatment of Diabetes

2011 ◽  
Vol 28 (8) ◽  
pp. 2008-2019 ◽  
Author(s):  
Hyunuk Kim ◽  
Juho Lee ◽  
Tae Hyung Kim ◽  
Eun Seong Lee ◽  
Kyung Taek Oh ◽  
...  
Keyword(s):  
Delivery System ◽  
Glycolic Acid ◽  
Inhalation Delivery ◽  
Treatment Of Diabetes ◽  
Long Acting

scholarly journals Exenatide-loaded inside-porous poly(lactic-co-glycolic acid) microspheres as a long-acting drug delivery system with improved release characteristics

Drug Delivery ◽  
2020 ◽  
Vol 27 (1) ◽  
pp. 1667-1675
Author(s):  
Junqiu Zhai ◽  
Zhanlun Ou ◽  
Liuting Zhong ◽  
Yu-e Wang ◽  
Li-Ping Cao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Glycolic Acid ◽  
Long Acting ◽  
Porous Poly

scholarly journals Long-acting reversible contraception by effervescent microneedle patch

2019 ◽  
Vol 5 (11) ◽  
pp. eaaw8145 ◽  
Author(s):  
Wei Li ◽  
Jie Tang ◽  
Richard N. Terry ◽  
Song Li ◽  
Aurelie Brunie ◽  
...  
Keyword(s):  
Biodegradable Polymer ◽  
Glycolic Acid ◽  
Interstitial Fluid ◽  
Threshold Level ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Human Participants ◽  
Microneedle Patch ◽  
Long Acting

To increase access to long-acting contraception, we developed a reversible contraceptive microneedle patch that is simple-to-administer, slowly releases contraceptive hormone (levonorgestrel) for >1 month, and generates no biohazardous sharps waste. After manually pressing the patch to skin for 1 min, microneedles rapidly separate from the patch within the skin due to effervescence triggered by contact with skin’s interstitial fluid, as demonstrated in rats and human participants. Long-acting contraception is achieved by formulating microneedles with a biodegradable polymer [poly(lactic-co-glycolic) acid] that slowly releases levonorgestrel for ~1 month in vitro. In rats, the patch maintained levonorgestrel concentration above the human contraceptive threshold level for >1 month, and a placebo microneedle patch was well-tolerated in human participants. Women of reproductive age in three continents demonstrated interest in and preference for long-acting contraception by microneedle patch. These studies indicate that an effervescent microneedle patch could facilitate greater access to long-acting contraception.

scholarly journals Shear Speed-Regulated Properties of Long-Acting Docetaxel Control Release Poly (Lactic-Co-Glycolic Acid) Microspheres

2020 ◽  
Vol 11 ◽  
Author(s):  
Yuhao Zheng ◽  
Fan Sheng ◽  
Zihang Wang ◽  
Guang Yang ◽  
Chenguang Li ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Control Release ◽  
Shear Speed ◽  
Long Acting

scholarly journals A potential long-acting bictegravir loaded nano-drug delivery system for HIV-1 infection: A proof-of-concept study

2019 ◽  
Vol 167 ◽  
pp. 83-88 ◽  
Author(s):  
Subhra Mandal ◽  
Pavan Kumar Prathipati ◽  
Michael Belshan ◽  
Christopher J. Destache
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Proof Of Concept ◽  
Concept Study ◽  
Nano Drug Delivery ◽  
Long Acting ◽  
Hiv 1

A long-acting formulation of a polypeptide drug exenatide in treatment of diabetes using an injectable block copolymer hydrogel

Biomaterials ◽  
2013 ◽  
Vol 34 (11) ◽  
pp. 2834-2842 ◽  
Author(s):  
Kun Li ◽  
Lin Yu ◽  
Xiaojun Liu ◽  
Chang Chen ◽  
Qinghua Chen ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Copolymer Hydrogel ◽  
Treatment Of Diabetes ◽  
Long Acting
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