scholarly journals Anti-angiogenic Effects of Bumetanide Revealed by DCE-MRI with a Biodegradable Macromolecular Contrast Agent in a Colon Cancer Model

2015 ◽  
Vol 32 (9) ◽  
pp. 3029-3043 ◽  
Author(s):  
Anthony S. Malamas ◽  
Erlei Jin ◽  
Qi Zhang ◽  
John Haaga ◽  
Zheng-Rong Lu
Keyword(s):  
Colon Cancer ◽  
Contrast Agent ◽  
Cancer Model ◽  
Dce Mri ◽  
Biodegradable Macromolecular Contrast Agent

An Orthotopic Colon Cancer Model for Studying the B7-H3 Antitumor Effect In Vivo

2006 ◽  
Vol 10 (5) ◽  
pp. 635-645 ◽  
Author(s):  
C LUPU ◽  
C EISENBACH ◽  
M KUEFNER ◽  
J SCHMIDT ◽  
A LUPU ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Antitumor Effect ◽  
Cancer Model

Effect of Tumor Volume on Drug Delivery in Heterogeneous Vasculature of Human Brain Tumors

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Ajay Bhandari ◽  
Ankit Bansal ◽  
Rishav Jain ◽  
Anup Singh ◽  
Niraj Sinha
Keyword(s):  
Drug Delivery ◽  
Brain Tumors ◽  
Human Brain ◽  
Contrast Agent ◽  
Large Volume ◽  
Interstitial Fluid ◽  
Tumor Volume ◽  
Drug Distribution ◽  
Dce Mri ◽  
Concentration Of Contrast Agent

Drug distribution in tumors is strongly dependent on tumor biological properties such as tumor volume, vasculature, and porosity. An understanding of the drug distribution pattern in tumors can help in enhancing the effectiveness of anticancer treatment. A numerical model is employed to study the distribution of contrast agent in the heterogeneous vasculature of human brain tumors of different volumes. Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) has been done for a number of patients with different tumor volumes. Leaky tracer kinetic model (LTKM) is employed to obtain perfusion parameters from the DCE-MRI data. These parameters are used as input in the computational fluid dynamics (CFD) model to predict interstitial fluid pressure (IFP), interstitial fluid velocity (IFV), and distribution of the contrast agent in different tumors. Numerical results demonstrate that the IFP is independent of tumor volume. On the other hand, the IFV increases as the tumor volume increases. Further, the concentration of contrast agent also increases with the tumor volume. The results obtained in this work are in line with the experimental DCE-MRI data. It is observed that large volume tumors tend to retain a higher concentration of contrast agent for a longer duration of time because of large extravasation flux and slow washout as compared to smaller tumors. These results may be qualitatively extrapolated to chemotherapeutic drug delivery, implying faster healing in large volume tumors. This study helps in understanding the effect of tumor volume on the treatment outcome for a wide range of human tumors.

Su1740 The Intestinal Stem Cells Marker LGR5 Is Regulated by Nutrients Availability and Differentiation in a Colon Cancer Model: Implications for Metabolism Based Therapies

2013 ◽  
Vol 144 (5) ◽  
pp. S-464-S-465
Author(s):  
Valentina Tesori ◽  
Maria Ausiliatrice Puglisi ◽  
Giovanni Gasbarrini ◽  
Antonio Gasbarrini
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Intestinal Stem Cells ◽  
Cancer Model ◽  
Nutrients Availability

Co-operation of α-galactosylceramide-loaded tumour cells and TLR9 agonists induce potent anti-tumour responses in a murine colon cancer model

2015 ◽  
Vol 473 (1) ◽  
pp. 7-19 ◽  
Author(s):  
Tiangeng Dong ◽  
Tuo Yi ◽  
Mengxuan Yang ◽  
Shengli Lin ◽  
Wenxiang Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumour Cells ◽  
Toll Like Receptor ◽  
Cancer Model ◽  
Cancer Vaccination ◽  
Tlr9 Agonist ◽  
Broad Applicability ◽  
Human Cancers ◽  
Anti Cancer ◽  
Murine Colon

This is the first demonstration that α-galactosylceramide (α-Galcer)-loaded tumour cells (tumour–Gal) plus the Toll-like receptor 9 (TLR9) agonist as therapeutic anti-cancer vaccination. This strategy may have broad applicability and lead to development of effective immunotherapy against various human cancers.

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