Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study

Abstract BackgroundAccumulating data have highlighted the prominence of supplementation as an effective approach for vitamin D deficiency. But individuals vary in their response to vitamin D supplementation. In this study, the effect of cardiometabolic risk factors were evaluate on magnitude of response to vitamin D supplementation by using novel statistical analysis, artificial neural networks(ANNs).Methods608 participants aged between 12 to 19 years old were assed in this prospective interventional study. Nine vitamin D capsules containing 50000IU vitamin D/weekly were given to all participants over the 9 week period. The change in serum 25(OH)D level was calculated as the difference between post-supplementation and basal levels. Suitable ANNs model were selected between different algorithms in the hidden and output layers and different numbers of neurons in the hidden layer. Then, the major determinants in predicting response to vitamin D supplementations were identified (Trial registration: IRCT201509047117N7; 2015-11-25; Retrospectively registered)ResultsSigmoid in both hidden and output layers with 4 hidden neurons had acceptable sensitivity, specificity and accuracy area under the ROC curve in our study. Baseline serum vitamin D (30.4%), waist to hip ratio (10.5%), BMI (10.5%), systolic blood pressure (8%), heart rate (6.4%), and waist circumference (6.1%) were the greatest importance in predicting the response in serum vitamin D levels. ConclusionWe provide the first attempt to relate anthropometric specific recommendations to attain serum vitamin D targets. With the exception of cardiometabolic risk factor, the relative importance of other factors and the mechanisms by which these factors may affect the response requires further analysis in future studies.

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Serum Vitamin D Levels in Male Blood Donors and Male Patients Coinfected With Human Immunodeficiency Virus and Tuberculosis: A Comparative Study

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqy092.159 ◽

2018 ◽

Vol 150 (suppl_1) ◽

pp. S64-S65

Author(s):

Carol Njeru

Keyword(s):

Vitamin D ◽

Human Immunodeficiency Virus ◽

Comparative Study ◽

Blood Donors ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Immunodeficiency Virus ◽

Male Patients

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A17942 Vitamin D deficiency would be a potential risk factor of severe obstructive sleep apnea in males aged than 45-year-old

Journal of Hypertension ◽

10.1097/01.hjh.0000549039.58222.9d ◽

2018 ◽

Vol 36 ◽

pp. e254

Author(s):

Xiaoguang Yao ◽

Mei Li ◽

Zhen Wei ◽

Mulalibieke Heizhati ◽

Xiufang Li ◽

...

Keyword(s):

Vitamin D ◽

Obstructive Sleep Apnea ◽

Risk Factor ◽

Sleep Apnea ◽

Vitamin D Deficiency ◽

Potential Risk ◽

Potential Risk Factor ◽

Severe Obstructive Sleep Apnea ◽

Obstructive Sleep

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Low Vitamin D Serum Levels May Be a Modifiable Risk Factor for Obesity and Cognitive Impairment in Middle-Age Egyptian Women

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2014.047 ◽

2014 ◽

Vol 2 (2) ◽

pp. 283-288

Author(s):

Yusr I. Kazem ◽

Maha I. A. Moaty ◽

Salwa M. El-Shebini ◽

Salwa T. Tapozada ◽

Laila M. Hanna

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Risk Factor ◽

Blood Glucose ◽

Serum Level ◽

Cognitive Functions ◽

Middle Age ◽

Fasting Blood Glucose ◽

Serum Vitamin ◽

Serum Vitamin D

OBJECTIVE: To evaluate the levels of serum vitamin D (25-hydroxyvitamin D) among obese Egyptian females and search possible association with cognitive functions and insulin resistance.SUBJECTS AND METHODS: This study included 2 groups, Group-1(cases) consists of 120 obese females and Group-2 (controls) consists of 30 non-obese females. The included females were subjected to full clinical examination, anthropometric measurements and Kendrick Battery for evaluation of cognitive functions (short term memory and attention). Evaluation of serum Vitamin D, Parathyroid hormone, C-peptide and fasting blood glucose were done. The obese group was put on a balanced low caloric diet (900-1000 K Calories/day) for 2 months, where reevaluation was performed.RESULTS: Comparing obese group with non-obese control group revealed significant lower mean level of serum vitamin D associated with significant lower cognitive functions test and higher fasting blood glucose. After 2 months of low caloric diet, a significant increase in the serum level of vitamin D, accompanied with improvement in cognitive functions and decrease in fasting blood glucose and improved insulin resistance was seen. A correlation is found between vitamin D serum level and cognitive functions.CONCLUSION: A lower vitamin D serum level could be a modifiable risk factor for obesity, insulin resistance and cognitive impairment in middle age females.

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Relationship between serum vitamin D and insulin resistance in normal weight and overweight or obese men.

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.11.237 ◽

2019 ◽

Vol 26 (11) ◽

pp. 1810-1814

Author(s):

Sabiha Iqbal ◽

Syed Imran Ali Shah ◽

Mirza Zeeshan Sikandar

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Comparative Study ◽

Serum Insulin ◽

Serum Vitamin ◽

Fasting Serum ◽

Cross Sectional ◽

Serum Vitamin D ◽

Glucose Levels ◽

Group Ii

Obesity is a common clinical disorder featuring excessive buildup of body fat. The bioavailability of vitamin D in obese subjects is lowered because of its sequestration in the superfluous fat tissue. Hypovitaminosis D itself is associated with glucose intolerance, insulin resistance, dyslipidemia and hypertension, which are also linked to obesity. Objectives: To compare and correlate serum vitamin D and insulin resistance in controls and overweight / obese males. Study Design: Cross Sectional, Comparative Study. Setting: The study was conducted in the Department of Physiology, Post – Graduate Medical Institute (PGMI) in collaboration with Lahore General Hospital and Central Park Medical College. Period: From 7th June 2018 to 10th Oct 2018. Material and Methods: Eighty male subjects (age range 35-50 years) included in this cross-sectional comparative study were divided into two groups on the basis of BMI; Group I: non-obese (control) BMI < 25 Kg/m2 (n=40) and Group II: overweight / obese males with BMI ˃25 Kg/m2 (n=40). Fasting serum vitamin D (25 hydroxy cholecalciferol; 25-OH D, serum insulin and blood glucose levels were measured. Insulin resistance (IR) was estimated from fasting serum glucose levels taken in mmol/l and the fasting serum insulin taken in µIU/ml by using Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR index). Results: Group II had lower serum 25-OH vitamin D levels and higher HOMA-IR index than control group. Significant negative correlation was present between serum vitamin D and HOMA-IR. Conclusion: Vitamin D deficiency may promote insulin resistance in overweight or obese individuals.

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PRESENCE OF LOW VITAMIN D AND HIGH SERUM LIPOPROTEIN 'A' LEVELS IN CAD: DO THEY IMPART RISK IN SYNERGISM?

10.36106/ijsr/0303309 ◽

2021 ◽

pp. 1-3

Author(s):

Prabhash Bhavsar ◽

Charanjeet Kaur ◽

BC Kabi

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Risk Factor ◽

Coronary Artery ◽

Serum Vitamin ◽

Inflammatory Disorder ◽

Lipoprotein A ◽

Serum Vitamin D ◽

Triple Vessel Disease ◽

Artery Disease

Aims: Coronary artery disease (CAD) is an inflammatory disorder. Recently low vitamin D and high lipoprotein ‘a’ (Lp‘a’) have been linked in causation of coronary artery disease. This study was conducted to see the the combined effect of these two modifiable risk factors i.e. low vitamin D and high Lp‘a’ in etiology of CAD. Methods: It was a cross sectional study. Triple vessel disease patients (n=31) admitted for bypass surgery were taken as cases and age and gender matched healthy persons were taken as controls (n=30). Serum vitamin D estimation was done by competitive ELISA method. Serum Lp‘a’ estimation was done by immunoturbidimetric assay. Results: when subjects were compared for dual risk factor (Vitamin D deficiency and Hyperlipoproteinemia‘a’), it was observed that the odds of having disease were very high (OR=30.00; p=0.0004) than the single risk factor (OR for Hypovitaminosis D = 3.33; p=0.03 and OR for Hyperlipoproteinemia ‘a’ = 5.00; p=0.004). The Pearson’s correlation coefficient for the relationship between serum Vitamin D and Lipoprotein ‘a’ shows no correlation (r = ̶ 0.1019). Conclusion: Risk of having CAD increases many folds when subject has vitamin D deficiecy as well as high Lp‘a’.

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Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin signaling

Aging ◽

10.18632/aging.103510 ◽

2020 ◽

Vol 12 (13) ◽

pp. 13824-13844 ◽

Cited By ~ 1

Author(s):

Ricardo Gómez-Oliva ◽

Noelia Geribaldi-Doldán ◽

Samuel Domínguez-García ◽

Livia Carrascal ◽

Cristina Verástegui ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Cognitive Decline ◽

Vitamin D Deficiency ◽

Potential Risk ◽

Accelerated Aging ◽

Hippocampal Neurogenesis ◽

Potential Risk Factor

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2332. Low Serum Vitamin D Levels Are Related to Life-Threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.2010 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S801-S801

Author(s):

Fausto Martin Ferolla ◽

Eduardo Walter Yfran ◽

Maria Gabriela Ballerini ◽

Analia Toledano ◽

Ana Caratozzolo ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Respiratory Syncytial Virus ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Healthy Infants ◽

Vitamin D Levels ◽

Life Threatening ◽

Rsv Infection ◽

Syncytial Virus

Abstract Background Serum 25-hydroxy-vitamin D (VD) effects on lung growth and immune system modulation might affect respiratory infections outcomes. Data are controversial regarding the role of VD status in the severity of Respiratory Syncytial Virus (RSV) infection. The aim of this study was to assess serum VD levels and its association with life-threatening disease (LTD) in previously healthy infants infected with RSV. Methods Prospective cohort study including previously healthy infants <12 months, hospitalized with a first RSV infection in 2017–2018. Viral load (VL) was assessed by qRT–PCR in nasopharyngeal aspirates and serum VD levels measured by ECLIA, in samples obtained on admission. VD deficiency was defined as levels <20 ng/mL, VD insufficiency 20–29 ng/mL, and LTD as need of intensive care and mechanical or noninvasive ventilation Results 98 patients, mean age 4.5 months (±3.1), 55 (56.1%) male. VD status: 18 (18.4%) with deficiency, 32 (32.6%) with insufficiency; 14 (77.8%) patients with deficiency had not received VD supplementation. There was no relationship between VD deficiency and anemia (P = 0.28) or age (P = 0.27). LTD was observed in 17 infants, with no significant differences in socioeconomic, pregnancy and infant variables compared with other RSV cases. Patients with LTD had significantly lower levels of VD (17.5 ng/mL [IQR 15.2–26.3] vs. 31.8 ng/mL [IQR 23.5–52.1, P < 0.001)], Figure 1. 15 patients, 88.2% of all infants with VD levels ≤29 ng/mL developed LTD compared with a study population frequency of LTD of 17.3%. Multivariable regression analysis including breastfeeding confirmed VD deficiency as a risk factor for LTD (aOR 14.3, 95% CI 3.9–51.5, P < 0.001). Normal VD values conferred protection (aOR 0.1, 95% CI 0.02–0.49, P = 0.004). VD levels inversely correlated with days of hypoxemia (P = 0.007); VD deficiency increased the risk of requiring O2 supplementation >7 days (aOR 8.5, P < 0.001). VL did not correlate with VD levels (P = 0.696), length of stay (P = 0.378), days of hypoxemia (P = 0.681). VL was not associated with LTD (P = 0.42). Conclusion Vitamin D deficiency was a risk factor for LTD in previously healthy infants with RSV infection. Viral titers did not correlate with VD levels. These findings provide additional evidence for the development of low-cost preventive and therapeutic strategies. Disclosures All authors: No reported disclosures.

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