Determination of acute oral toxicity of glyphosate isopropylamine salt in rats

2020 ◽  
Vol 27 (16) ◽  
pp. 19298-19303
Author(s):  
Ruhi Turkmen ◽  
Ilkay Dogan
Keyword(s):  
Acute Oral Toxicity ◽  
Oral Toxicity

Investigation of antiulcer activity of Pergularia extensa Linn

2020 ◽  
Vol 9 (2) ◽  
pp. 23-26
Author(s):  
Pavani C H
Keyword(s):  
Cardiac Glycosides ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Antiulcer Activity ◽  
Acute Oral Toxicity ◽  
Gastric Lesions ◽  
Oral Toxicity ◽  
Control Groups ◽  
Dose Dependent

This study was based on determination of the antiulcer activity from methanol extract was prepared by using barks of pergularia extensa linn.. Priliminary investigations showed presence of saponins, terpenes, cardiac glycosides, alkaloids and sterols. Based on OECD-423 Guidelines, the pharmacology and acute oral toxicity studies were conducted by using methanolic extract. Ulcer development was prevented by Tannins because of their vasoconstriction effects and due to protein precipitation. Similarly, the Methanolic extract of Pergularia extensa Linn shows triterpenoids and saponins. The phytoconstituents are present in the extract and these could be possible agents which are involved in order to prevent gastric lesions induced by aspirin. When compared to ulcerative control groups, this Pergularia extensa Linn., shows a dose dependent curative ratio. The extracts exhibited an inhibition percentage of 27.18, 45.47 and 61.28 at doses of 100, 200 and 400mg/kg doses respectively. 

Acute Oral Toxicity Determination of Methyl Pyridyl Ketone in the Rat

1992 ◽  
Vol 11 (6) ◽  
pp. 681-681 ◽  
Author(s):  
A. C. Costello ◽  
R. C. Myers ◽  
C. E. Manderfield ◽  
T. G. Osimitz
Keyword(s):  
Acute Oral Toxicity ◽  
Oral Toxicity

Determination of the acute oral toxicity of theophylline in conscious dogs

1988 ◽  
Vol 11 (4) ◽  
pp. 381-389 ◽  
Author(s):  
I.J. MUNSIFF ◽  
B.C. MCKIERNAN ◽  
C. A. NEFF-DAVIS ◽  
G. D. KORITZ
Keyword(s):  
Conscious Dogs ◽  
Acute Oral Toxicity ◽  
Oral Toxicity

Acute Oral Toxicity Determination of Acetylcyclopentanone in the Rat

1992 ◽  
Vol 11 (6) ◽  
pp. 680-680
Author(s):  
A. C. Costello ◽  
R. C. Myers ◽  
C. E. Manderfield ◽  
T. G. Osimitz
Keyword(s):  
Acute Oral Toxicity ◽  
Oral Toxicity

Estimation of acute oral toxicity in rates by determination of the approximate lethal dose rather than the LD50

1986 ◽  
Vol 6 (3) ◽  
pp. 145-148 ◽  
Author(s):  
Gerald L. Kennedy ◽  
Rayanne L. Ferenz ◽  
Bruce A. Burgess
Keyword(s):  
Lethal Dose ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Approximate Lethal Dose

scholarly journals Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Toxins ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 75 ◽  
Author(s):  
Paula Abal ◽  
M. Louzao ◽  
Alvaro Antelo ◽  
Mercedes Alvarez ◽  
Eva Cagide ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Lethal Dose ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Adverse Effect Level ◽  
Effect Level

scholarly journals Determination of Acute Oral Toxicity of Flumethrin in Honey Bees

2012 ◽  
Vol 105 (6) ◽  
pp. 1890-1894 ◽  
Author(s):  
H. H. Oruc ◽  
J. M. Hranitz ◽  
A. Sorucu ◽  
M. Duell ◽  
I. Cakmak ◽  
...  
Keyword(s):  
Honey Bees ◽  
Acute Oral Toxicity ◽  
Oral Toxicity

Determination of the Starting dose for Acute Oral Toxicity (LD50) Testing in the up and down Procedure (UDP) from Cytotoxicity Data

1999 ◽  
Vol 27 (6) ◽  
pp. 957-966 ◽  
Author(s):  
Horst Spielmann ◽  
Elke Genschow ◽  
Manfred Liebsch ◽  
Willi Halle
Keyword(s):  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Starting Dose

scholarly journals Preliminary Acute Toxicological Analysis and Profiling of a Commercially Available Mangosteen (Garcinia mangostana) Xanthone Capsule

10.17158/487 ◽  
2016 ◽  
Vol 19 (1) ◽  
Author(s):  
Kenny James Merin
Keyword(s):  
Serum Creatinine ◽  
Positive Likelihood Ratio ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Test Animal ◽  
Garcinia Mangostana ◽  
Toxicological Profile ◽  
Liver And Kidney ◽  
Serum Glutamic Pyruvate Transaminase

<p>Mangosteen is known for its wide variety of healing properties, but studies on its toxicity remained insufficient. Toxicological profile of commercially available Garcinia mangostana xanthone capsule was evaluated using a true experimental research design. Acute oral toxicity and toxicant category were employed. After the test animal was administered with xanthone capsule, biomarker such as Alanine Transaminase (ALT), Serum Glutamic Pyruvate Transaminase (SGPT), Blood Urea Nitrogen (BUN) and Serum Creatinine levels were evaluated using the Swiss albino mice. Histopathological (liver and kidney) analyses were conducted and determination of mutagenicity and heavy metals (Cd, Pb and Hg) were also pursued. Results reveal that acute oral toxicity dose had zero deaths from 300, 2000 up to 5000 mg/ kg. This classified in category 5 as nontoxic (OECD 423). ALT/SGPT value of 125.00±21.9317 was higher than the normal (0-41 u/L). BUN (7.75 ± 0.1858) and serum creatinine (93.00±20.0749) exhibited higher than the normal at 1.78-6.07 umol/L and 44 umol/L, respectively. This means the sample may cause hepatotoxicity and nephrotoxicity. Analysis on positive likelihood ratio of 1.333 was higher than the negative ratio of 0.6667 while kidney had 1.333 higher than the negative ratio of 0.6667. No revertant colony was observed using Salmonella typhimurium TA98 compared to the benzene (368 colonies). It was within the allowable limits for lead (0.003 µg/g) and mercury (0.002 µg/g). However, cadmium exceeded the limits of 0.01 having a mean of 0.23 µg/g.</p><p> </p><p><strong>Keywords:</strong> Pharmacology, toxicology, Garcinia mangostana, xanthone, experimental, Davao City, Philippines.</p>

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