<p>Mangosteen is known for its wide variety of healing properties, but studies on its toxicity remained insufficient. Toxicological profile of commercially available Garcinia mangostana xanthone capsule was evaluated using a true experimental research design. Acute oral toxicity and toxicant category were employed. After the test animal was administered with xanthone capsule, biomarker such as Alanine Transaminase (ALT), Serum Glutamic Pyruvate Transaminase (SGPT), Blood Urea Nitrogen (BUN) and Serum Creatinine levels were evaluated using the Swiss albino mice. Histopathological (liver and kidney) analyses were conducted and determination of mutagenicity and heavy metals (Cd, Pb and Hg) were also pursued. Results reveal that acute oral toxicity dose had zero deaths from 300, 2000 up to 5000 mg/ kg. This classified in category 5 as nontoxic (OECD 423). ALT/SGPT value of 125.00±21.9317 was higher than the normal (0-41 u/L). BUN (7.75 ± 0.1858) and serum creatinine (93.00±20.0749) exhibited higher than the normal at 1.78-6.07 umol/L and 44 umol/L, respectively. This means the sample may cause hepatotoxicity and nephrotoxicity. Analysis on positive likelihood ratio of 1.333 was higher than the negative ratio of 0.6667 while kidney had 1.333 higher than the negative ratio of 0.6667. No revertant colony was observed using Salmonella typhimurium TA98 compared to the benzene (368 colonies). It was within the allowable limits for lead (0.003 µg/g) and mercury (0.002 µg/g). However, cadmium exceeded the limits of 0.01 having a mean of 0.23 µg/g.</p><p> </p><p><strong>Keywords:</strong> Pharmacology, toxicology, Garcinia mangostana, xanthone, experimental, Davao City, Philippines.</p>
Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)
