Investigation of antiulcer activity of Pergularia extensa Linn

2020 ◽  
Vol 9 (2) ◽  
pp. 23-26
Author(s):  
Pavani C H
Keyword(s):  
Cardiac Glycosides ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Antiulcer Activity ◽  
Acute Oral Toxicity ◽  
Gastric Lesions ◽  
Oral Toxicity ◽  
Control Groups ◽  
Dose Dependent

This study was based on determination of the antiulcer activity from methanol extract was prepared by using barks of pergularia extensa linn.. Priliminary investigations showed presence of saponins, terpenes, cardiac glycosides, alkaloids and sterols. Based on OECD-423 Guidelines, the pharmacology and acute oral toxicity studies were conducted by using methanolic extract. Ulcer development was prevented by Tannins because of their vasoconstriction effects and due to protein precipitation. Similarly, the Methanolic extract of Pergularia extensa Linn shows triterpenoids and saponins. The phytoconstituents are present in the extract and these could be possible agents which are involved in order to prevent gastric lesions induced by aspirin. When compared to ulcerative control groups, this Pergularia extensa Linn., shows a dose dependent curative ratio. The extracts exhibited an inhibition percentage of 27.18, 45.47 and 61.28 at doses of 100, 200 and 400mg/kg doses respectively. 

Acute Oral Toxicity Determination of Methyl Pyridyl Ketone in the Rat

1992 ◽  
Vol 11 (6) ◽  
pp. 681-681 ◽  
Author(s):  
A. C. Costello ◽  
R. C. Myers ◽  
C. E. Manderfield ◽  
T. G. Osimitz
Keyword(s):  
Acute Oral Toxicity ◽  
Oral Toxicity

Evaluation of anticonvulsant potential of aqueous methanolic extract and various fractions of Ajuga bracteosa wall

2017 ◽  
Vol 2 (2) ◽  
pp. 137
Author(s):  
Sumera Qasim ◽  
Ambreen Malik Uttra ◽  
Umme Habiba Hasan ◽  
Amna Batool
Keyword(s):  
Plant Extract ◽  
Anticonvulsant Activity ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Anticonvulsant Effect ◽  
Gaba Level ◽  
Animal Models Of Epilepsy ◽  
Dose Dependent ◽  
Brain Gaba ◽  
Models Of Epilepsy

We aim to assess the anticonvulsant potential of Ajuga bracteosa Wall. The aqueous methanol extract (30:70) of Ajuga bracteosa and its n-hexane, chloroform and ethyl acetate fractions were prepared. Anticonvulsant effect was evaluated using different animal models of epilepsy. Crude extract along with its fractions at 500 and 1000 mg/kg doses, administered orally to albino mice were appraised against pentylenetetrazole-induced, strychnine-induced and picrotoxin-induced convulsions. Moreover, effect of test substances on brain GABA level and phenobarbitone induced hypnosis was also studied at dose level of 350 and 400 mg/kg. The plant extract and its fractions produced potent dose dependent anticonvulsant activity in all models of epilepsy. In addition, plant extract and fractions increased brain GABA level and potentiated phenobarbitone-induced sleep duration. From the results it can be deduced that Ajuga bracteosa possess potent anticonvulsant activity, supporting its folkloric use in the treatment of epilepsy.

Acute Oral Toxicity Study of Asiasari radix Extract in Mice

2007 ◽  
Vol 26 (3) ◽  
pp. 247-251 ◽  
Author(s):  
T. Ramesh ◽  
K. Lee ◽  
H. W. Lee ◽  
S. J. Kim
Keyword(s):  
Body Weight ◽  
Oral Administration ◽  
Food Consumption ◽  
Methanol Extract ◽  
The Body ◽  
Toxicity Study ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Organ Weights ◽  
Icr Mice

Acute oral toxicity of methanol extract of Asiasari radix was evaluated in ICR mice of both sexes. In this study, mice were administrated orally with dosages of 1000, 3000, and 5000 mg/kg body weight of Asiasari radix extract. Mortality, signs of toxicity, body weight, food consumption, and gross findings were observed for 14 days post treatment of Asiasari radix extract. No mortality, signs of toxicity, and abnormalities in gross findings were observed. In addition, no significant differences were noticed in the body and organ weights between the control and treated groups of both sexes. These results show that the methanol extract of Asiasari radix is toxicologically safe by oral administration.

Determination of the acute oral toxicity of theophylline in conscious dogs

1988 ◽  
Vol 11 (4) ◽  
pp. 381-389 ◽  
Author(s):  
I.J. MUNSIFF ◽  
B.C. MCKIERNAN ◽  
C. A. NEFF-DAVIS ◽  
G. D. KORITZ
Keyword(s):  
Conscious Dogs ◽  
Acute Oral Toxicity ◽  
Oral Toxicity

scholarly journals Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat

2019 ◽  
Vol 7 (2) ◽  
pp. 59-61
Author(s):  
R. K. Gupta ◽  
Ravi Vishwakarma ◽  
Yashwant Giri ◽  
Varinder Singh
Keyword(s):  
Gastric Ulcer ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Gastric Volume ◽  
Gastric Ulceration ◽  
Antiulcer Activity ◽  
Free Acidity ◽  
Ulcer Index ◽  
Whole Plant ◽  
Symplocos Racemosa

Peptic ulcer is a condition which results from an imbalance between offensive and defensive factors of gastrointestinal system. The investigation was designed to evaluate the antiulcer activity of Symplocos racemosa whole plant methanol extract (MESR) in rat model of indomethacininduced gastric ulceration. The total acidity, gastric volume, pH and free acidity were measured to determine the anti-ulcer activity of MESR. Pretreatment with MESR (125-500 mg/kg) markedly reduced the indomethacin-induced increase in gastric ulcer index and score. These results revealed that antisecretory effects MESR were responsible for antiulcer activity of MESR.

Evaluation of Anti-hyperuricemic Activity of the Alcoholic Extract of Dried Capparis moonii Wight Fruits in Wistar Rats

2021 ◽  
pp. 3173-3178
Author(s):  
Shruti Ramesh Shettigar ◽  
Vanita G. Kanase
Keyword(s):  
Wistar Rats ◽  
The Body ◽  
Alcoholic Extract ◽  
Phenol Red ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Dried Fruits ◽  
Treatment Agent ◽  
Dose Dependent ◽  
Potassium Oxonate

Evaluation of anti-hyperuricemic activity of alcoholic extract of Capparis moonii Wight fruits in Wistar rats, by utilizing Indian caper typically occurring in the Konkan area which grows full-fledged in the hot and dry atmosphere that can be generally found throughout asia. The dried fruits of Capparis moonii W. were extracted using absolute ethanol to get an alcoholic extract. Acute oral toxicity studies were performed to decide the doses. The anti-hyperuricemic activity was estimated by the phenol red excretion in rats and the potassium oxonate induced hyperuricemia models respectively. The alcoholic extract showed dose-dependent mode of action where the higher concentration of 200 mg/kg showed higher amount of retention of phenol red in the blood suggesting that it has better ability to secrete urate out of the body of rats as compared to 100mg/kg. Also in potassium oxonate induced hyperuricemia, similar results were obtained with significant reduction in serum uric acid levels and serum creatinine levels as compared to 100mg/kg. The conclusion of this study was that; it proved that Capparis moonii W. alcoholic extract of the fruits can be beneficial as anti-hyperuricemic treatment agent. It would be encouraging to undertake further studies in future to decode the exact mechanism.

scholarly journals CNS Depressant and Antiepileptic Activities of the Methanol Extract of the Leaves ofIpomoea AquaticaForsk

2010 ◽  
Vol 7 (4) ◽  
pp. 1555-1561 ◽  
Author(s):  
Dhanasekaran Sivaraman ◽  
Palayan Muralidaran
Keyword(s):  
Exploratory Behavior ◽  
Methanol Extract ◽  
Complete Protection ◽  
Oral Toxicity ◽  
Sleeping Time ◽  
Cns Depressant ◽  
The Central Nervous System ◽  
Hole Board ◽  
Dose Dependent ◽  
Pentobarbitone Sleeping Time

The central nervous system (CNS) depressant and antiepileptic activities of the methanol extract of the leaves ofIpomoea aquaticaForsk (IAF) were investigated on various animal models including pentobarbitone sleeping time and hole-board exploratory behavior for sedation tests and strychnine, picrotoxin and pentylenetetrazole-induced convulsions in mice. IAF (200 and 400 mg/kg, p.o.), like chlorpromazine HCl (1 mg/kg, i.m.), produced a dose-dependent prolongation of pentobarbitone sleeping time and suppression of exploratory behavior. IAF (200 and 400 mg/kg) produced dose-dependent and significant increases in onset to clonic and tonic convulsions and at 400 mg/kg, showed complete protection against seizures induced by strychnine and picrotoxin but not with pentylenetetrazole. Acute oral toxicity test, up to 14 days, did not produce any visible signs of toxicity. These results suggest that potentially antiepileptic compounds are present in leaf extract of IAF that deserve the study of their identity and mechanism of action.

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