Gut Microbiota Diversity and Overweight/Obesity in Infancy: Results from a Nested Case-control Study

2022 ◽  
Author(s):  
Hong Mei ◽  
Neng Li ◽  
Yan Zhang ◽  
Dan Zhang ◽  
An-na Peng ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Microbiota Diversity ◽  
Control Study

scholarly journals Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study

2017 ◽  
Vol 5-6 ◽  
pp. 11-13 ◽  
Author(s):  
Deborah Traversi ◽  
Ivana Rabbone ◽  
Maria Giovanna Ignaccolo ◽  
Giulia Carletto ◽  
Irene Racca ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Preliminary Data ◽  
Case Control Study ◽  
Case Control ◽  
Microbiota Diversity ◽  
Control Study

Association Of Gut Microbiota During Early Pregnancy With Risk Of Incident Gestational Diabetes Mellitus: A Nested Case-Control Study

2020 ◽  
Author(s):  
Ping Hu ◽  
Xiuyi Chen ◽  
Xufeng Chu ◽  
Mengran Fan ◽  
Yi Ye ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gut Microbiota ◽  
Early Pregnancy ◽  
Case Control Study ◽  
Postprandial Glucose ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study ◽  
Subsequent Risk

Abstract Background: We aimed to assess gut bacterial biomarkers during early pregnancy and subsequent risk of gestational diabetes mellitus (GDM) in Chinese pregnant women.Methods: Based on the Tongji-Shuangliu Birth Cohort study, we conducted a nested case-control study among 201 incident GDM cases and 201 matched controls individual matched on age, gestational week, and date of fecal sample collection. Fecal samples were collected during early pregnancy, and GDM was diagnosed at 24-28 weeks of pregnancy. Community DNA isolated from fecal samples and V3-V4 region of 16S rRNA gene amplicon libraries were sequenced. Results: In GDM cases versus controls, Rothia, Actinomyces, Bifidobacterium, Adlercreutzia, and Coriobacteriaceae, and Lachnospiraceae spp. were significantly reduced, while Enterobacteriaceae, Ruminococcaceae spp. and Veillonellaceae were over-represented. It was also found that the abundance of Staphylococcus relative to Clostridium, Roseburia and Coriobacteriaceae as reference microorganisms were positively correlated with fasting blood glucose, 1-h postprandial glucose, and 2-h postprandial glucose levels. Conditional Logistic regression showed that 4 microbial taxa during early pregnancy were associated with subsequent GDM risk, including Actinobacteria, Coriobacteriaceae, genus 26 of Coriobacteriaceae and an unknown specie of the Coprococcus.Conclusion: Gut microbiota during early pregnancy was associated with subsequent risk of GDM. Several beneficial and commensal gut microorganisms showed inverse relations with incident GDM, while opportunistic pathogenic members involving in GDM development, where they positively correlated with clinical measurements on OGTT. Our study provided promising biological markers that may be used in monitoring pregnant women’s health and developing therapeutic interventions on GDM at early stage of gestation.

Association between glycaemic control and fracture risk in diabetic patients: a nested case control study

2019 ◽  
Author(s):  
J Vavanikunnel ◽  
S Charlier ◽  
C Becker ◽  
C Schneider ◽  
SS Jick ◽  
...  
Keyword(s):  
Glycaemic Control ◽  
Fracture Risk ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Patients ◽  
Nested Case Control ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document