scholarly journals Shared and specific patterns of structural and functional thalamo-frontal disturbances in manic and euthymic pediatric bipolar disorder

2021 ◽  
Vol 15 (5) ◽  
pp. 2671-2680
Author(s):  
Yi-Bing Guo ◽  
Wei-Jia Gao ◽  
Zhi-Liang Long ◽  
Wei-Fang Cao ◽  
Dong Cui ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cortical Thickness ◽  
Vital Role ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
Detailed Knowledge ◽  
Precentral Gyrus ◽  
Treatment Target ◽  
Clinical Indices ◽  
Left Thalamus

AbstractBipolar disorder (BD) is clinically defined by alternating depressive and manic episodes with a separated period of euthymia. Thalamo-frontal loop plays vital role in psychotic symptoms, altered motor control and executive difficulties in BD. It remains unclear that structural and functional alterations of thalamo-frontal loop among the different mood states in BD, especially in pediatric BD(PBD).Twenty manic PBD (mPBD), 20 euthymic PBD (ePBD) and 19 healthy controls (HCs) were included in the study. By analyzing the T1 images and fMRI signals, thalamus volume and frontal grey matter cortical thickness were tested, and functional connectivity (FC) between bilateral thalamus and frontal cortex was calculated. Relationship between clinical indices and thalamo-frontal FC was also evaluated in mPBD and ePBD adolescents.Compared to HCs, the cortical thickness of left middle frontal gyrus (MFG), bilateral superior frontal gyrus (SFG) was significantly decreased in both mPBD and ePBD patients, and volume of left thalamus and cortical thickness of right MFG significantly decreased in mPBD patients. Compared to that of the HCs and ePBD subjects, thalamo-frontal hyperconnectivity with MFG was found in mPBD, and compared with that of HCs, thalamo-frontal hypoconnectivity with precentral gyrus/SFG was found in ePBD. In ePBD patients, episode times positively correlated with FC values between thalamus and precentral gyrus.The findings of the present study demonstrate detailed knowledge regarding shared and specific structural and functional disruption in thalamo-frontal loop in mPBD and ePBD subjects. Thalamo-frontal abnormalities reported in adult BD subjects were also observed in adolescent BD patients, and thalamo-frontal dysfunction may be a crucial treatment target in BD.

scholarly journals Shared And Specific Patterns Of Structural And Functional Thalamo-Frontal Disturbances In Manic And Euthymic Pediatric Bipolar Disorder

2021 ◽  
Author(s):  
Yi-Bing Guo ◽  
Wei-Jia Gao ◽  
Zhi-Liang Long ◽  
Wei-Fang Cao ◽  
Dong Cui ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cortical Thickness ◽  
Vital Role ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
Detailed Knowledge ◽  
Precentral Gyrus ◽  
Treatment Target ◽  
Clinical Indices ◽  
Left Thalamus

Abstract Bipolar disorder (BD) is clinically defined by alternating depressive and manic episodes with a separated period of euthymia. Thalamo-frontal loop plays vital role in psychotic symptoms, altered motor control and executive difficulties in BD. It remains unclear that structural and functional alteration of thalamo-frontal loop among the different mood states in BD, especially in pediatric BD(PBD).Twenty manic PBD(mPBD), 20 euthymic PBD(ePBD) and 19 healthy controls were included in the study. By analyzing the T1 images and fMRI signals, thalamus volume and frontal grey matter cortical thickness were tested, and functional connectivity(FC) between bilateral thalamus and frontal cortex was calculated. Relationship between clinical indices and thalamo-frontal FC was also evaluated in mPBD and ePBD adolescents.Compared to HCs, the cortical thickness of left MFG, bilateral superior frontal gyrus(SFG) was significantly decreased in both mPBD and ePBD patients, and volume of left thalamus and cortical thickness of right middle frontal gyrus(MFG) significantly decreased in mPBD patients. It was shown that thalamo-frontal hyperconnectivity with MFG in mPBD compared to HCs and ePBD subjects, and thalamo-frontal hypoconnectivity with precentral gyrus/SFG in ePBD subjects compared with that of HCs. In ePBD patients, episode times positively correlated with FC values between thalamus and precentral gyrusThe findings of the present study demonstrate detailed knowledge regarding shared and specific structural and functional disruption in thalamo-frontal loop in mPBD and ePBD subjects. Thalamo-frontal abnormalities reported in adult BD subjects were also observed in adolescent BD patients, and thalamo-frontal dysfunction may be a crucial treatment target in BD.

Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness

2006 ◽  
Vol 96 (1-2) ◽  
pp. 127-131 ◽  
Author(s):  
Richard Rende ◽  
Boris Birmaher ◽  
David Axelson ◽  
Michael Strober ◽  
Mary Kay Gill ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Psychiatric Illness ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
History Of

scholarly journals Cortical Correlates of Impulsive Aggressive Behavior in Pediatric Bipolar Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Alessio Simonetti ◽  
Sherin Kurian ◽  
Johanna Saxena ◽  
Christopher D. Verrico ◽  
Antonio Restaino ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cortical Thickness ◽  
Clinical Findings ◽  
Anterior Cingulate ◽  
Pediatric Bipolar Disorder ◽  
Magnetic Resonance Imaging Scan ◽  
Frontoparietal Network ◽  
Impulsive Aggression ◽  
Left And Right ◽  
The Relationship

Background: Impulsive aggression represents a frequent characteristic of pediatric bipolar disorder (PBD). Cortical alterations associated with impulsive aggression and its multiple facets have not been investigated yet in youth with bipolar disorder.Aim: To investigate the relationship between cortical thickness and facets of impulsive aggression in youth with PBD.Materials and Methods: Twenty-three youth with PBD and 23 healthy controls (HC) were administered the aggression questionnaire (AQ) and underwent 3T magnetic resonance imaging scan. Cortical thickness was assessed with FreeSurfer. Canonical correlation analyses were used to investigate the relationship between AQ total and subscale scores and cortical thickness in youth with PBD.Results: Youth with PBD had increased scores in the subscales of AQ-anger and AQ-hostility and cortical thinning in in areas belonging to the affective network (AN), frontoparietal network (FPN) and cingulo-opercular network (CON), i.e., right rostral anterior cingulate, right caudal anterior cingulate, right lateral orbitofrontal, right medial orbitofrontal, left and right inferior parietal, left posterior cingulate, left and right supramarginal left lingual cortices. Greater thickness in these networks positively correlated with the AQ-hostility subscale and negatively correlated with AQ-anger subscale.Conclusions: The opposite patterns observed between areas belonging to AN, FPN, CON, and the two facets of IA, namely anger and hostility, corroborate clinical findings supporting the different nature of these two constructs.

scholarly journals Disrupted brain structural connectivity in Pediatric Bipolar Disorder with psychosis

2017 ◽  
Author(s):  
Henrique M. Fernandes ◽  
Joana Cabral ◽  
Tim J. Van Hartevelt ◽  
Louis-David Lord ◽  
Carsten Gleesborg ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Network Topology ◽  
Orbitofrontal Cortex ◽  
Emotional Processing ◽  
Brain Connectivity ◽  
Structural Connectivity ◽  
Brain Regions ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
Integrative Processing

AbstractBipolar disorder (BD) has been linked to disrupted structural and functional connectivity between prefrontal networks and limbic brain regions. Studies of patients with pediatric bipolar disorder (PBD) can help elucidate the developmental origins of altered structural connectivity underlying BD and provide novel insights into the aetiology of BD. Here we compare the network properties of whole-brain structural connectomes of PBD patients with psychosis and euthymic matched healthy controls. Our results show widespread changes in the structural connectivity of PBD patients in both cortical and subcortical networks, notably affecting the orbitofrontal cortex, frontal gyrus, amygdala, hippocampus and basal ganglia. Graph theoretical analysis revealed that PBD connectomes have fewer hubs, weaker rich club organization, different modular fingerprint and inter-modular communication, compared to healthy participants. The relationship between network features and neurocognitive and psychotic scores was also assessed. Patients’ IQ and psychotic symptoms significantly correlated with the local efficiency of the orbitofrontal cortex. Our findings reveal that PBD is associated with significant widespread changes in structural network topology, thus strengthening the hypothesis of a reduced capacity for integrative processing of information across brain regions. Localised network changes involve core regions for emotional processing and regulation, as well as memory and executive function, some of which correlate with neurocognitive faculties and symptoms. Together, our findings provide the first comprehensive characterisation of the alterations in local and global structural brain connectivity and network topology, which may contribute to the deficits in cognition and emotion processing and regulation found in PBD.

Psychotic symptoms in pediatric bipolar disorder

2004 ◽  
Vol 80 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Mani N. Pavuluri ◽  
Ellen S. Herbener ◽  
John A. Sweeney
Keyword(s):  
Bipolar Disorder ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder

scholarly journals Alterations of Cognition and Cerebral Ventricle Volume in Manic and Euthymic Pediatric Bipolar Disorder

2020 ◽  
Vol 11 ◽  
Author(s):  
Liangfeng Kuang ◽  
Dong Cui ◽  
Qing Jiao ◽  
Yongxin Guo ◽  
Weifang Cao ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Performance ◽  
Digit Span ◽  
Third Ventricle ◽  
Magnetic Resonance Images ◽  
Pediatric Bipolar Disorder ◽  
Ventricular Volumes ◽  
Clinical Indices ◽  
Ventricle Volume ◽  
The Relationship

Introduction: It remains unknown whether volumetric alterations of ventricles are similar or not in pediatric bipolar disorder (PBD) among different mood states. The present study aims to estimate ventricular volumetric alteration of PBD patients in manic and euthymic status, as well as the relationship between this alteration and cognitive changes.Methods: T1 magnetic resonance images were obtained from 20 manic PBD patients, 21 euthymic PBD patients, and 19 healthy controls (HCs). Ventricular volumes were automatically obtained via FreeSurfer 6.0 software. Ventricular volumes and cognitive indices were compared among the three groups, and the relationship between ventricular volumes and cognitive/clinical indices was analyzed.Results: In contrast to HCs, manic and euthymic PBD patients exhibited decreased cognitive scores of the Stroop color-word test and the digit span subtest. Manic PBD subjects presented enlarged volumes in the bilateral ventricles, third ventricle, and whole ventricles, and euthymic PBD participants displayed increased volumes in the third ventricle, fourth ventricle, and whole ventricles. No significant differences in cognitive performance and ventricular volumes were found between PBD groups. No significant correlation was discovered between ventricular volumes and cognitive/clinical indices in both manic and euthymic PBD patients.Conclusions: No significant differences in cognitive performance and ventricle volume were observed between euthymic and manic PBD groups, which may imply that the alterations are not specific to mood state. It may indicate structural and functional damage of corresponding brain circuits in euthymic PBD patients similar with that of manic PBD, which may provide clues to the diagnosis and treatment of euthymic PBD.

scholarly journals Disrupted brain structural connectivity in Pediatric Bipolar Disorder with psychosis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Henrique M. Fernandes ◽  
Joana Cabral ◽  
Tim J. van Hartevelt ◽  
Louis-David Lord ◽  
Carsten Gleesborg ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Network Topology ◽  
Orbitofrontal Cortex ◽  
Emotional Processing ◽  
Brain Connectivity ◽  
Structural Connectivity ◽  
Brain Regions ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
Integrative Processing

Abstract Bipolar disorder (BD) has been linked to disrupted structural and functional connectivity between prefrontal networks and limbic brain regions. Studies of patients with pediatric bipolar disorder (PBD) can help elucidate the developmental origins of altered structural connectivity underlying BD and provide novel insights into the aetiology of BD. Here we compare the network properties of whole-brain structural connectomes of euthymic PBD patients with psychosis, a variant of PBD, and matched healthy controls. Our results show widespread changes in the structural connectivity of PBD patients with psychosis in both cortical and subcortical networks, notably affecting the orbitofrontal cortex, frontal gyrus, amygdala, hippocampus and basal ganglia. Graph theoretical analysis revealed that PBD connectomes have fewer hubs, weaker rich club organization, different modular fingerprint and inter-modular communication, compared to healthy participants. The relationship between network features and neurocognitive and psychotic scores was also assessed, revealing trends of association between patients’ IQ and affective psychotic symptoms with the local efficiency of the orbitofrontal cortex. Our findings reveal that PBD with psychosis is associated with significant widespread changes in structural network topology, thus strengthening the hypothesis of a reduced capacity for integrative processing of information across brain regions. Localised network changes involve core regions for emotional processing and regulation, as well as memory and executive function, some of which show trends of association with neurocognitive faculties and symptoms. Together, our findings provide the first comprehensive characterisation of the alterations in local and global structural brain connectivity and network topology, which may contribute to the deficits in cognition and emotion processing and regulation found in PBD.

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