Reply to the Response to: Impact of COVID-19 Lockdown on Short-Term Weight Loss in a Single Italian Institution: 1-Year Updated Data

We evaluated the association between short-term change in body mass index (BMI) and breast density during a 1 year weight-loss intervention (Manchester, UK). We included 65 premenopausal women (35–45 years, ≥7 kg adult weight gain, family history of breast cancer). BMI and breast density (semi-automated area-based, automated volume-based) were measured at baseline, 1 year, and 2 years after study entry (1 year post intervention). Cross-sectional (between-women) and short-term change (within-women) associations between BMI and breast density were measured using repeated-measures correlation coefficients and multivariable linear mixed models. BMI was positively correlated with dense volume between-women (r = 0.41, 95%CI: 0.17, 0.61), but less so within-women (r = 0.08, 95%CI: −0.16, 0.28). There was little association with dense area (between-women r = −0.12, 95%CI: −0.38, 0.16; within-women r = 0.01, 95%CI: −0.24, 0.25). BMI and breast fat were positively correlated (volume: between r = 0.77, 95%CI: 0.69, 0.84, within r = 0.58, 95%CI: 0.36, 0.75; area: between r = 0.74, 95%CI: 0.63, 0.82, within r = 0.45, 95%CI: 0.23, 0.63). Multivariable models reported similar associations. Exploratory analysis suggested associations between BMI gain from 20 years and density measures (standard deviation change per +5 kg/m2 BMI: dense area: +0.61 (95%CI: 0.12, 1.09); fat volume: −0.31 (95%CI: −0.62, 0.00)). Short-term BMI change is likely to be positively associated with breast fat, but we found little association with dense tissue, although power was limited by small sample size.

Download Full-text

Short-term Effects of Supplementation with a Multi-ingredient Weight-loss Product on Weight Maintenance and Fat Oxidation in Obese Female with Weight Reduction: Preliminary Results

Journal of Obesity & Weight loss Therapy ◽

10.4172/2165-7904.1000231 ◽

2014 ◽

Vol 04 (04) ◽

Cited By ~ 1

Author(s):

Naoki Sakane

Keyword(s):

Weight Loss ◽

Weight Reduction ◽

Weight Maintenance ◽

Fat Oxidation ◽

Short Term ◽

Loss Product ◽

Preliminary Results ◽

Weight Loss Product ◽

Obese Female ◽

Short Term Effects

Download Full-text

The influence of food restriction on the small bowel: Does intensive short‑term food restriction lead to weight loss?

Bratislava Medical Journal ◽

10.4149/bll_2017_068 ◽

2017 ◽

Vol 118 (06) ◽

pp. 361-365

Author(s):

P. Makovicky ◽

E. Tumova ◽

Z. Volek ◽

P. Makovicky ◽

J. M. Arnone ◽

...

Keyword(s):

Weight Loss ◽

Small Bowel ◽

Food Restriction ◽

Short Term ◽

Influence Of Food

Download Full-text

Adding Rifaximin and Midodrine Enhances Diuresis in Refractory or Recurrent Ascites with Improvement in Clinical Outcome including Renal Function, Weight Loss and Short Term Survival

Journal of Hepatology ◽

10.1016/s0168-8278(16)01223-x ◽

2016 ◽

Vol 64 (2) ◽

pp. S653

Author(s):

A.S. Hanafy

Keyword(s):

Weight Loss ◽

Renal Function ◽

Clinical Outcome ◽

Short Term ◽

Term Survival ◽

Short Term Survival

Download Full-text

Short-Term Results of Single-Anastomosis Gastric Bypass After Failed Sleeve Gastrectomy

QJM ◽

10.1093/qjmed/hcab097.039 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Alaa Abbas Sabry ◽

Karim Sabry Abd-Elsamee ◽

Mohamed Ibrahim Mohamed ◽

Mohammed Mohamed Ahmed Abd-Elsalam

Keyword(s):

Weight Loss ◽

Gastric Bypass ◽

Sleeve Gastrectomy ◽

Weight Regain ◽

Revisional Surgery ◽

One Anastomosis Gastric Bypass ◽

Short Term ◽

Multicenter Studies ◽

Metabolic Outcomes

Abstract Background It is already known that Laparoscopic sleeve gastrectomy (LSG) has gained popularity as a stand-alone procedure with good short-term results for weight loss. However, in the long-term, weight regain is considered as a complication. Demand for secondary surgery is rising, partly for this reason, but through that study we try to discover the efficacy of conversion of failed sleeve gastrectomy to one anastomosis gastric bypass (OAGB) regarding weight loss and metabolic outcomes. Objective To asses the efficacy and safety of one anastomosis gastric bypass (OAGB) as a conversion surgery post Sleeve Gastrectomy failure as regard weight loss and metabolic outcomes. Patients and Methods This study is a retrospective cohort study which included 20 patients underwent one anastomosis gastric bypass at Ain-Shams University El-Demerdash Hospital, Cairo, Egypt and specialized bariatric center, Cairo, Egypt From February 2019 to July 2019 with 6 months of postoperative follow up till January 2019. Results In this study, we reviewed and analyzed the outcomes from the revision of the SG due to either inadequate weight loss or weight regain to one anastomosis gastric bypass (OAGB) with %EBWL of 6.65% at 1 month, 13.61 % at 3 months and 20.86% at 6 months. Conclusion OAGB appears to be an effective and safe therapeutic technique as a revisional surgery for failed primary SG with good short-term results for treating morbid obesity and its associated comorbidities with a significantly low rate of complications. However the EBWL was less than what is reported after primary OAGB weight. Multicenter studies with larger series of patients and longer term follow up after SG revisions to OAGB are warranted.

Download Full-text

Abstract P290: Short-term Weight Change and Long-term Mortality in the Trials of Hypertension Prevention

Circulation ◽

10.1161/circ.133.suppl_1.p290 ◽

2016 ◽

Vol 133 (suppl_1) ◽

Author(s):

Nancy R Cook ◽

Lawrence J Appel ◽

Paul K Whelton

Keyword(s):

Weight Loss ◽

Weight Change ◽

Phase 1 ◽

Total Mortality ◽

Weight Loss Intervention ◽

Phase 2 ◽

Short Term ◽

Hypertension Prevention ◽

Long Term Mortality

Introduction: Although weight loss has favorable effects on intermediate outcomes, such as blood pressure and insulin resistance, few studies have examined its effects on long-term outcomes including total mortality. Methods: In the Trials of Hypertension Prevention (TOHP) individuals aged 30-54 years with high normal BP were randomized to a weight loss intervention, to one of several other lifestyle or dietary supplement interventions, or to usual care. All participants from Phase 1 (1987-90) and Phase 2 (1990-5) were followed for mortality through 2013. The association of weight change during any of the interventions with long-term mortality up to 18-24 years after the trial periods was examined among 3828 participants who fell into a high baseline weight stratum, defined as body mass index at least 26 kg/m2 in men and 24 kg/m2 in women. Results and Conclusions: There were 1477 high-weight participants in Phase 1 and 2351 in Phase 2, of whom 21% and 50%, respectively, were assigned to a weight loss intervention. Overall, mean weight change during the trial period was -1.8 lbs (-0.8% of baseline body weight) over 1.5 years in Phase 1 and 1.6 lbs (0.8%) over 3-4 years in Phase 2. A total of 556 (15%) lost > 5%, 1,101 (29%) lost <=5%, 1,567 (41%) gained less than 5%, and 604 (16%) gained > 5% in body weight. Corresponding hazard ratios (HRs) for total mortality were 0.82 (95% confidence interval (CI)=0.57-1.18), 0.94 (95% CI=0.72-1.23), 1.00 (reference), and 1.29 (95% CI=0.92-1.80) (p-trend = 0.046). There was a direct linear relationship with percent change in weight during the trial period and later mortality (HR=1.14 per 5% change, 95% CI=1.02-1.28, p=0.019). This association persisted throughout the course of mortality follow-up (Figure). In these healthy individuals taking part in lifestyle and nutrition supplement trials , short-term weight change was directly associated with mortality about two decades later. These results are consistent with a long-term beneficial effect of presumed intentional weight loss on total mortality.

Download Full-text

Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2017-211472 ◽

2017 ◽

Vol 76 (11) ◽

pp. 1870-1882 ◽

Cited By ~ 40

Author(s):

Sabrina M Nielsen ◽

Else M Bartels ◽

Marius Henriksen ◽

Eva E Wæhrens ◽

Henrik Gudbergsen ◽

...

Keyword(s):

Systematic Review ◽

Bariatric Surgery ◽

Weight Loss ◽

Longitudinal Studies ◽

Randomised Trial ◽

Risk Of Bias ◽

Current Evidence ◽

Short Term ◽

Quality Of Evidence

ObjectivesWeight loss is commonly recommended for gout, but the magnitude of the effect has not been evaluated in a systematic review. The aim of this systematic review was to determine benefits and harms associated with weight loss in overweight and obese patients with gout.MethodsWe searched six databases for longitudinal studies, reporting the effect of weight loss in overweight/obese gout patients. Risk of bias was assessed using the tool Risk of Bias in Non-Randomised Studies of Interventions. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation.ResultsFrom 3991 potentially eligible studies, 10 were included (including one randomised trial). Interventions included diet with/without physical activity, bariatric surgery, diuretics, metformin or no intervention. Mean weight losses ranged from 3 kg to 34 kg. Clinical heterogeneity in study characteristics precluded meta-analysis. The effect on serum uric acid (sUA) ranged from −168 to 30 μmol/L, and 0%–60% patients achieving sUA target (<360 μmol/L). Six out of eight studies (75%) showed beneficial effects on gout attacks. Two studies indicated dose–response relationship for sUA, achieving sUA target and gout attacks. At short term, temporary increased sUA and gout attacks tended to occur after bariatric surgery.ConclusionsThe available evidence is in favour of weight loss for overweight/obese gout patients, with low, moderate and low quality of evidence for effects on sUA, achieving sUA target and gout attacks, respectively. At short term, unfavourable effects may occur. Since the current evidence consists of a few studies (mostly observational) of low methodological quality, there is an urgent need to initiate rigorous prospective studies (preferably randomised controlled trials).Systematic review registrationPROSPERO, CRD42016037937.

Download Full-text

The PROMOTE study (High-protein and resistance-training combination in overweight and obesity) for short-term weight loss and long-term weight maintenance for Chinese people: a protocol for a pilot randomized controlled trial

Trials ◽

10.1186/s13063-019-3954-7 ◽

2020 ◽

Vol 21 (1) ◽

Cited By ~ 1

Author(s):

Shaoyong Xu ◽

Juan Zhang ◽

Yuxiang Dong ◽

Ruikun Chen ◽

Wenlei Xu ◽

...

Keyword(s):

Weight Loss ◽

Resistance Training ◽

Controlled Trial ◽

Weight Maintenance ◽

High Protein Diet ◽

Diet Group ◽

High Protein ◽

Protein Diet ◽

Short Term ◽

Low Fat Diet

Abstract Background It is very important for clinicians and dieticians to explore reasonable weight management strategies for obese people that address both short-term weight loss and subsequent weight maintenance. We hypothesized that resistance training combined with a high-protein diet would result in similar short-term weight loss but better long-term weight maintenance than either a conventional low-fat diet control or a high-protein diet alone. Methods/design This is an 8-week randomized parallel controlled trial followed by a 24-week observational follow-up study. A 48-week supplementary follow-up study will be carried out if necessary. The study will be conducted between June 2019 and October 2020. The 90 overweight or obese participants will be randomly assigned to the conventional low-fat diet group, the high-protein diet group and the high-protein diet and resistance training combination group. Primary outcomes are body weight change at week 8 and week 24 compared with the baseline level. Discussion High-quality research on the effect of a high-protein diet combined resistance training on weight loss and weight maintenance is limited in the Chinese population. Our study will provide a basis for obesity management in China and will promote the development of exercise- and diet-related studies. Trial registration Chinese Clinical Trial Registry, ChiCTR1900023841. Registered on 14 June 2019.

Download Full-text