scholarly journals Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

2021 ◽  
Author(s):  
Fabio de Moliner ◽  
Ina Biazruchka ◽  
Karolina Konsewicz ◽  
Sam Benson ◽  
Suraj Singh ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Small Molecule ◽  
Near Infrared ◽  
Aqueous Media ◽  
Biological Imaging ◽  
Low Molecular Weight ◽  
Synthetic Approach ◽  
Spectral Window ◽  
Infrared Spectral ◽  
Environmentally Sensitive

AbstractThe development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging. In this work, we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors. C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most near-infrared dyes. We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+ and Fe3+ ions in aqueous media.

scholarly journals A targeted low molecular weight near-infrared fluorescent probe for prostate cancer

2010 ◽  
Vol 20 (23) ◽  
pp. 7124-7126 ◽  
Author(s):  
Tiancheng Liu ◽  
Lisa Y. Wu ◽  
Mark R. Hopkins ◽  
Joseph K. Choi ◽  
Clifford E. Berkman
Keyword(s):  
Prostate Cancer ◽  
Molecular Weight ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Low Molecular Weight

Low molecular weight polyethylenimine-conjugated gold nanospheres: a platform for selective gene therapy controlled by near-infrared light

Nanomedicine ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. 511-534 ◽  
Author(s):  
Fei Liu ◽  
Fen-fen Kong ◽  
Qing-po Li ◽  
Hong Yuan ◽  
Yong-zhong Du ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Molecular Weight ◽  
Near Infrared ◽  
Infrared Light ◽  
Low Molecular Weight ◽  
Gold Nanospheres ◽  
Near Infrared Light

scholarly journals Core remodeling leads to long wavelength fluoro-coumarins

2020 ◽  
Vol 11 (28) ◽  
pp. 7302-7307 ◽  
Author(s):  
Siddharth S. Matikonda ◽  
Joseph Ivanic ◽  
Miguel Gomez ◽  
Gabrielle Hammersley ◽  
Martin J. Schnermann
Keyword(s):  
Molecular Weight ◽  
Near Infrared ◽  
Low Molecular Weight ◽  
Long Wavelength

Fluoro-Coumarins are a novel class of far-red and near-infrared solvent sensitive dyes of exceptionally low molecular weight.

scholarly journals Polythiophenes with Cationic Phosphonium Groups as Vectors for Imaging, siRNA Delivery, and Photodynamic Therapy

Nanomaterials ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1432
Author(s):  
Laure Lichon ◽  
Clément Kotras ◽  
Bauyrzhan Myrzakhmetov ◽  
Philippe Arnoux ◽  
Morgane Daurat ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Combined Therapy ◽  
Sirna Delivery ◽  
Aqueous Media ◽  
Low Molecular Weight ◽  
Oxygen Species ◽  
Cationic Polymers ◽  
Intracellular Location

In this work, we exploit the versatile function of cationic phosphonium-conjugated polythiophenes to develop multifunctional platforms for imaging and combined therapy (siRNA delivery and photodynamic therapy). The photophysical properties (absorption, emission and light-induced generation of singlet oxygen) of these cationic polythiophenes were found to be sensitive to molecular weight. Upon light irradiation, low molecular weight cationic polythiophenes were able to light-sensitize surrounding oxygen into reactive oxygen species (ROS) while the highest were not due to its aggregation in aqueous media. These polymers are also fluorescent, allowing one to visualize their intracellular location through confocal microscopy. The most promising polymers were then used as vectors for siRNA delivery. Due to their cationic and amphipathic features, these polymers were found to effectively self-assemble with siRNA targeting the luciferase gene and deliver it in MDA-MB-231 cancer cells expressing luciferase, leading to 30–50% of the gene-silencing effect. In parallel, the photodynamic therapy (PDT) activity of these cationic polymers was restored after siRNA delivery, demonstrating their potential for combined PDT and gene therapy.

scholarly journals Binding assay for low molecular weight analytes based on reflectometry of absorbing molecules in porous substrates

The Analyst ◽  
2014 ◽  
Vol 139 (8) ◽  
pp. 1987-1992 ◽  
Author(s):  
Milena Stephan ◽  
Corinna Kramer ◽  
Claudia Steinem ◽  
Andreas Janshoff
Keyword(s):  
Molecular Weight ◽  
Small Molecule ◽  
Binding Assay ◽  
Pharmaceutical Research ◽  
Low Molecular Weight ◽  
Porous Substrates

Small molecule sensing is of great importance in pharmaceutical research.

Interactions governing the entrapment of anticancer drugs by low-molecular-weight hydrogelator for drug delivery applications

RSC Advances ◽  
2016 ◽  
Vol 6 (24) ◽  
pp. 19751-19757 ◽  
Author(s):  
Siddhi Gupta ◽  
Manish Singh ◽  
Amarendar Reddy M. ◽  
Prabhu S. Yavvari ◽  
Aasheesh Srivastava ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Anticancer Drugs ◽  
Small Molecule ◽  
Low Molecular Weight ◽  
Drug Encapsulation ◽  
Drug Delivery Applications

We present the effect of size, charge, and hydrophobicity of anticancer drugs on their drug encapsulation efficacy in anl-alanine-based small-molecule hydrogelator.

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