Vitamin E reduces cholesterol esterification and uptake of acetylated low density lipoprotein in macrophages

Lipids ◽  
1998 ◽  
Vol 33 (12) ◽  
pp. 1169-1175 ◽  
Author(s):  
Hideki Shige ◽  
Toshitsugu Ishikawa ◽  
Michio Suzukawa ◽  
Masato Nishiwaki ◽  
Takeshi Yamashita ◽  
...  
Keyword(s):  
Vitamin E ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cholesterol Esterification ◽  
Low Density

scholarly journals POTENSI BUAH MERAH (Pandanus conoideus Lam.) DALAM MENURUNKAN KADAR LDL DARAH TIKUS PUTIH

2017 ◽  
Vol 3 (1) ◽  
pp. 48 ◽  
Author(s):  
Oki Sandra Agnesa ◽  
Joko Waluyo ◽  
Jekti Prihatin ◽  
Sri Rahayu Lestari
Keyword(s):  
Reactive Oxygen Species ◽  
Vitamin E ◽  
Rattus Norvegicus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Reactive Oxygen ◽  
Low Density ◽  
Oxygen Species ◽  
One Way Anova

Penyakit jantung koroner (PJK) terutama disebabkan oleh aterosklerosis karena hiperkolesterolimia. Oksidasi low density lipoprotein (LDL) oleh reactive oxygen species (ROS) sebagai penyebab utama proses aterogenik dapat dicegah dengan kehadiran antioksidan seperti vitamin E. Buah dan sayuran banyak mengandung vitamin. Salah satu buah yang mengandung vitamin E adalah buah merah (Pandanus conoideus Lam.). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak buah merah terhadap kadar LDL darah pada tikus putih (Rattus norvegicus L.). Jenis penelitian ini adalah penelitian eksperimental laboratorium yang didesain mengikuti Rancangan Acak Lengkap (RAL) dengan 6 perlakuan dan 4 kali ulangan dengan parameter penelitian adalah kadar LDL darah tikus putih. Data dianalisis menggunakan one way anova dilanjutkan dengan uji Duncan 95%. Berdasarkan hasil penelitian, minyak buah merah memiliki kemampuan untuk menurunkan kadar LDL darah tikus putih.

scholarly journals Comparative study between the prophylactics Effects of aqueous extract of Black Currant (Vitis vinferia.L) and vitamin E on some biological parameters related with heart diseases in oxidative Stressed rats

2008 ◽  
Vol 32 (2) ◽  
pp. 227-252
Author(s):  
Abdul-Katum A. H.
Keyword(s):  
Drinking Water ◽  
Platelet Count ◽  
Vitamin E ◽  
Prothrombin Time ◽  
Aqueous Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Black Currant ◽  
Oral Intubation

This study was designed to investigate the prophylactic effect of aqueousextract of black currant concentrate on some biological markers related withheart disease in male rat treated H2O2. It also aimed at comparing theprophylactic effect of black currant concentrate to that of vit E.Forty adult male rats were divided randomly into equal groups (tenrat/group) & were treated as follows for 42 days. Rats in the first group (G І)were received normal water with oral intubation of sun flower oil 1ml /rat andconsider as control group. Animals of the second group (G Π) were received0.5% H2O2 in drinking water, while rats of the third group (G Ш) were received0.5% H2O2 in drinking water with oral intubation of vit E 400 I.U/Kg.B.Wdiluting in sun flower oil for each rat daily .While animals in the fourth group (GІV) were intubated daily 60mg/kg body weight of aqueous extract of blackcurrant concentrate plus 0.5% H2O2 in drinking water.Fasting blood samples were collected at 0, 21, and 42 days of experimentto study the following parameters:A - Platelet count (PC) and prothrombin time (PT).B- Serum concentration of total cholesterol TC, triacylglycerol TAG, Highdensity lipoprotein-cholesterol HDL-C, Low density lipoprotein-cholesterolLDL-C and Very low density lipoprotein- cholesterol VLDL-C of each groupwere measured. These parameters were regarded as biomarkers ofatherosclerosis and coronary heart disease (CHD). Furthermore section of heart& aorta were assessed for histopathogical studies.The result revealed that administration of 0.5% H2O2 in drinking water for sixweeks (42days) caused significant increase (p<0.05) in platelet count & in serumTC,TAG,LDL-C, and VLDL-C concentration with significant decrease(p<0.05)in prothrombin time and HDL-C concentration as compared to other groups, onother hand oral intubation of vitamin E or aqueous extract of black currantconcentrate in addition to H2O2 (groups Ш and ІV respectively) decreased theserum concentration of TC, TAG, LDL-C, VLDL-C, and platelet countIraqi Journal of Veterinary Medicine Vol. 32, No. 2, 2008228

scholarly journals Atherogenic Lipoproteins Support Assembly of the Prothrombinase Complex and Thrombin Generation: Modulation by Oxidation and Vitamin E

Blood ◽  
1998 ◽  
Vol 91 (2) ◽  
pp. 508-515 ◽  
Author(s):  
Simin Rota ◽  
Nicola A. McWilliam ◽  
Trevor P. Baglin ◽  
Christopher D. Byrne
Keyword(s):  
Endothelial Cells ◽  
Vitamin E ◽  
Thrombin Generation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Lipoprotein Oxidation ◽  
Prothrombinase Complex

AbstractThe importance of lipoproteins in the etiology of atherosclerosis is well established. Evidence is now accumulating to implicate thrombin in the pathogenesis of atherosclerosis. We have investigated whether atherogenic lipoproteins can support thrombin generation. In the absence of platelets or endothelial cells, both very low-density lipoprotein (VLDL) and oxidized low-density lipoprotein (LDL) support assembly of the prothrombinase complex and generation of thrombin. Thrombin generation (per μg of apolipoprotein) supported by VLDL was 19.4-fold greater than that supported by high-density lipoprotein (HDL), P < .00001, and 11.7-fold greater than that supported by LDL, P < .00001. Oxidation of LDL increased lipoprotein-supported thrombin generation 12-fold compared to unmodified LDL, P < .0001. We have shown that the phenomenon of lipoprotein-supported thrombin generation is mediated predominantly by specific phospholipids and is enhanced by oxidation of these phospholipids. The addition of vitamin E (α-tocopherol) markedly reduced the increase in thrombin generation observed after oxidation of LDL (822 ± 57 v 138 ± 47 nmol/L;P < .0001). These effects suggest that lipoproteins are important in the production of thrombin and that vitamin E may confer protection from the detrimental effects of lipoprotein oxidation by limiting thrombin formation. These results suggest that atherogenic lipoproteins are linked to the development of atherosclerosis in part by their capacity to support thrombin generation.

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