Aldehyde and Xanthine Oxidase Activities in Tissues of Streptozotocin-Induced Diabetic Rats: Effects of Vitamin E and Selenium Supplementation

2012 ◽  
Vol 147 (1-3) ◽  
pp. 217-225 ◽  
Author(s):  
Tayyebeh Ghaffari ◽  
Mohammad Nouri ◽  
Amir Ata Saei ◽  
Mohammad-Reza Rashidi
Keyword(s):  
Vitamin E ◽  
Xanthine Oxidase ◽  
Diabetic Rats ◽  
Selenium Supplementation

scholarly journals Tocotrienol Rich Palm Oil Extract Is More Effective Than Pure Tocotrienols at Improving Endothelium-Dependent Relaxation in the Presence of Oxidative Stress

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Saher F. Ali ◽  
Owen L. Woodman
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Endothelial Function ◽  
Xanthine Oxidase ◽  
Palm Oil ◽  
Oxidant Stress ◽  
Rat Aorta ◽  
Isolated Aorta ◽  
Oil Extract ◽  
Endothelium Dependent Relaxation

Oxidative endothelial dysfunction is a critical initiator of vascular disease. Vitamin E is an effective antioxidant but attempts to use it to treat vascular disorders have been disappointing. This study investigated whether tocotrienols, the less abundant components of vitamin E compared to tocopherols, might be more effective at preserving endothelial function. Superoxide generated by hypoxanthine/xanthine oxidase or rat aorta was measured using lucigenin-enhanced chemiluminescence. The effect ofα-tocopherol,α-,δ-, andγ-tocotrienols and a tocotrienol rich palm oil extract (tocomin) on levels of superoxide was assessed. Endothelial function in rat aorta was assessed in the presence of the auto-oxidant pyrogallol. Whilst all of the compounds displayed antioxidant activity, the tocotrienols were more effective when superoxide was produced by hypoxanthine/xanthine oxidase whereas tocomin andα-tocopherol were more effective in the isolated aorta. Tocomin andα-tocopherol restored endothelial function in the presence of oxidant stress butα-,δ-, andγ-tocotrienols were ineffective. The protective effect of tocomin was replicated when the tocotrienols were present with, but not without,α-tocopherol. Tocotrienol rich tocomin is more effective thanα-tocopherol at reducing oxidative stress and restoring endothelium-dependent relaxation in rat aortae and althoughα-,δ-, andγ-tocotrienols effectively scavenged superoxide, they did not improve endothelial function.

Functional Recovery and Vitamin E Level Following Sciatic Nerve Crush Injury in Normal and Diabetic Rats

1998 ◽  
Vol 96 (3-4) ◽  
pp. 245-254 ◽  
Author(s):  
Khalaf Al Moutaery ◽  
Mohammed Arshaduddin ◽  
Mohammad Tariq ◽  
Saleh Al Deeb
Keyword(s):  
Vitamin E ◽  
Sciatic Nerve ◽  
Functional Recovery ◽  
Diabetic Rats ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Crush Injury

Effects of Vitamin E on Serum Glucose Levels and Nephropathy in Streptozotocin-Diabetic Rats

2005 ◽  
pp. 268-272
Author(s):  
M. James C. Crabbe ◽  
B. Üstündag ◽  
M. Cay ◽  
M. Naziroglu ◽  
N. Ilhan ◽  
...  
Keyword(s):  
Vitamin E ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Glucose Levels ◽  
Streptozotocin Diabetic Rats
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