scholarly journals Cancer Mortality and Long-Term Environmental Exposure of Cadmium in Contaminated Community Based on a Third Retrospective Cause of Death Investigation of Residents Living in the Guangdong Province from 2004 to 2005

2021 ◽  
Author(s):  
Aili Jiang ◽  
Lijuan Gong ◽  
Hao Ding ◽  
Mao Wang
Keyword(s):  
Lung Cancer ◽  
Esophageal Cancer ◽  
Cancer Mortality ◽  
Total Population ◽  
Guangdong Province ◽  
Exposure Group ◽  
Low Exposure ◽  
Cd Exposure ◽  
Cancer Mortality Risk

AbstractThis study compared the temporal and geographic trends of cancer in China with a specific focus on the long-term exposure to soil cadmium (Cd) pollution. The geographic information system (GIS; kriging interpolation method) was used to detect the Cd contained in the soil from the Dabaoshan area, Guangdong Province. The standard rate ratio (SRR) was calculated to describe the relationship between Cd exposure and cancer mortality risk using the low-exposure group as a reference. Eight hundred six cancer deaths (533 male and 273 female) in the total population of 972,970 were identified, and the age-standardized rate (world) was 145.64 per 100,000. Significant dose-response relationships were found using the low-exposure group as the reference group. The Cd soil levels were positively associated with the cancer mortality risk in the community population, particularly for all cancers (SRR = 3.27; 95% CI = 2.42–4.55), esophageal cancer (SRR = 5.42; 95% CI = 1.07–30.56), stomach cancer (SRR = 5.99; 95% CI = 2.00–18.66), liver cancer (SRR = 4.45; 95% CI = 2.16–10.34), and lung cancer (SRR = 2.86; 95% CI = 1.62–5.31) for the total population. Additionally, similar results were obtained when using the 2000 China standard population. Cd exposure significantly affected the standardized mortality rates (China) by age group for all cancers, esophageal cancer, stomach cancer, liver cancer, and lung cancer in the total population, particularly in the age groups of 35–54, 55–74, and ≥ 75 years, respectively. Cd soil level is likely positively associated with increased cancer mortality of all cancer types and esophageal, stomach, liver, and lung cancers but not for other specific categories of cancer.

scholarly journals Long-Term PM2.5 Exposure and Respiratory, Cancer, and Cardiovascular Mortality in Older US Adults

2017 ◽  
Vol 186 (8) ◽  
pp. 961-969 ◽  
Author(s):  
Vivian C Pun ◽  
Fatemeh Kazemiparkouhi ◽  
Justin Manjourides ◽  
Helen H Suh
Keyword(s):  
Lung Cancer ◽  
Particulate Matter ◽  
Confidence Interval ◽  
Cancer Mortality ◽  
Moving Average ◽  
Lung Cancer Mortality ◽  
Pm2.5 Exposure ◽  
Risk Ratios ◽  
Cancer Mortality Risk

Abstract The impact of chronic exposure to fine particulate matter (particulate matter with an aerodynamic diameter less than or equal to 2.5 μm (PM2.5)) on respiratory disease and lung cancer mortality is poorly understood. In a cohort of 18.9 million Medicare beneficiaries (4.2 million deaths) living across the conterminous United States between 2000 and 2008, we examined the association between chronic PM2.5 exposure and cause-specific mortality. We evaluated confounding through adjustment for neighborhood behavioral covariates and decomposition of PM2.5 into 2 spatiotemporal scales. We found significantly positive associations of 12-month moving average PM2.5 exposures (per 10-μg/m3 increase) with respiratory, chronic obstructive pulmonary disease, and pneumonia mortality, with risk ratios ranging from 1.10 to 1.24. We also found significant PM2.5-associated elevated risks for cardiovascular and lung cancer mortality. Risk ratios generally increased with longer moving averages; for example, an elevation in 60-month moving average PM2.5 exposures was linked to 1.33 times the lung cancer mortality risk (95% confidence interval: 1.24, 1.40), as compared with 1.13 (95% confidence interval: 1.11, 1.15) for 12-month moving average exposures. Observed associations were robust in multivariable models, although evidence of unmeasured confounding remained. In this large cohort of US elderly, we provide important new evidence that long-term PM2.5 exposure is significantly related to increased mortality from respiratory disease, lung cancer, and cardiovascular disease.

scholarly journals Portable stove use is associated with lower lung cancer mortality risk in lifetime smoky coal users

2008 ◽  
Vol 99 (11) ◽  
pp. 1934-1939 ◽  
Author(s):  
H D Hosgood ◽  
R Chapman ◽  
M Shen ◽  
A Blair ◽  
E Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mortality Risk ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
Lower Lung ◽  
Smoky Coal ◽  
Cancer Mortality Risk

County-level variation in the long-term association between PM2.5 and lung cancer mortality in China

2020 ◽  
Vol 738 ◽  
pp. 140195 ◽  
Author(s):  
Ning Wang ◽  
Kerrie Mengersen ◽  
Shilu Tong ◽  
Michael Kimlin ◽  
Maigeng Zhou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
County Level ◽  
Level Variation

BMI, long-term changes in BMI, and risk of cancer mortality in a large cohort study.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1502-1502
Author(s):  
Niloofar Taghizadeh ◽  
Judith M. Vonk ◽  
H. Marike Boezen
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Lung Cancer ◽  
Cohort Study ◽  
Mortality Risk ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
Prostate Cancer Mortality ◽  
Risk Of Mortality ◽  
Cancer Mortality Risk

1502 Background: There are indications of an association between Body Mass Index (BMI) and risk of different cancer types. There is dispute whether this association differs between males and females. Methods: We studied the association of BMI at the first survey with risk of mortality from the most common types of cancer (lung, colorectal, breast and prostate cancer) in a large general population-based cohort study (Vlagtwedde-Vlaardingen, 1965-1990) with follow-up on mortality status until 2009. Additionally, we assessed this association based on tertiles of the annual change in BMI (defined as the difference between BMI at last survey and first survey divided by the time between last and first survey). We used 3 categories of BMI (< 25 kg/m2, 25-30 kg/m2, and ≥ 30 kg/m2) and changes in BMI (< 0.02 kg/m2/yr, 0.02-0.2 kg/m2/yr, and > 0.2 kg/m2/yr) in the analyses. The multivariate Cox regression model was adjusted for age, smoking, gender. Analyses were additionally stratified by gender and smoking. Results: Among all 8645 subjects, 1194 died due to cancer (lung cancer: 275; colorectal cancer: 134; breast cancer: 117; prostate cancer: 83). Mortality from all types of cancer was significantly increased in subjects with BMI > 30 kg/m2 (HR (95 % CI)) = 1.22 (1.00-1.48)), especially in females (1.38 (1.06-1.81)) and in never smokers (1.39 (1.02-1.90)). Prostate cancer mortality was significantly increased in males with BMI 25-30 kg/m2 (2.04 (1.90-3.83)) and > 30 kg/m2 (2.61 (1.02-6.67)). This association between prostate cancer mortality and BMI was higher in smokers. Lung cancer mortality risk was decreased in subjects with BMI 25-30 kg/m2 (0.71 (0.54-0.93)) and > 30 kg/m2 (0.82 (0.50-1.32)), especially in males, in smokers, and in smoking males. There were no significant associations between BMI and colorectal or breast cancer mortality nor between change in BMI and mortality from all analyzed types of cancer. Conclusions: We show that an increase in BMI is associated with an increased risk of mortality from all types of cancer in females and with an increased mortality risk from prostate cancer in males but with a decreased lung cancer mortality risk, especially in males. More research is needed into the biological mechanisms that link BMI to cancer.

LONG-TERM EXPOSURE TO AIR POLLUTION AND LUNG CANCER MORTALITY IN SCOTLAND

Epidemiology ◽  
2005 ◽  
Vol 16 (5) ◽  
pp. S79 ◽  
Author(s):  
C Yap ◽  
I Beverland ◽  
R M. Agius ◽  
C Robertson ◽  
D J. Hole ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Air Pollution ◽  
Cancer Mortality ◽  
Lung Cancer Mortality

Long-Term Changes in Premature Death of Lung Cancer in a Developed Region of China: A Population-Based Study From 1973 to 2019

2021 ◽  
Author(s):  
Wenjing Ye ◽  
Weiwei Lu ◽  
Yibo Ding ◽  
Yichen Chen ◽  
Lin Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mortality Rate ◽  
Total Population ◽  
Temporal Trends ◽  
Demographic Factors ◽  
Premature Death ◽  
Years Of Life Lost ◽  
Registration System ◽  
Long Term Changes

Abstract Background: Lung cancer is a leading cause of deaths worldwide, and its incidence shows an upward trend. The study in the long-term changes in premature death of lung cancer in a developed region of China has a great exploratiory significance to further clarify the effectiveness of intervention measures.Methods: Cancer death data were collected from the Mortality Registration System of Shanghai Pudong New Area (PNA). We analysed crude mortality rate (CMR), age-standardized mortality rate by Segi’s world standard population (ASMRW), and years of life lost (YLL) of lung cancer from 1973 to 2019. Temporal trends of CMR, ASMRW, and rate of YLL were calculated by joinpoint regression expressed as an annual percent change (APC) with corresponding 95% confidence interval.Results: 80,543,137 person-years were enrolled in this study in PNA from 1973 to 2019. There were 42,229 deaths in permanent residents from lung cancer. The CMR and ASMRW were 52.43/105 person-years and 27.79/105 person-years. YLL due to premature death from lung cancer was 481779.14 years, and the rate of YLL was 598.16/105 person-years. The CMR, and rate of YLL for deaths had significantly increasing trends in males, females, and the total population (P<0.001). The CMR in the total population increased by 2.86% (95% CI=2.66%-3.07%, P < 0.001) per year during the study period. The YLL rate increased with an APCC of 2.21% (95% CI = 1.92% to 2.51%, P < 0.001) per year. The contribution rates of increased values of CMR caused by demographic factors were more evident than non-demographic factors.Conclusion: The aging population, progress of treatment, smoking, and even environmental pollution may be the factors that affect the long-term changes in premature death of lung cancer in PNA from1973 to 2019. Our research can help us to understand the changes of lung cancer mortality, and our results could also be used for other similar cities in designing future prevention plans.

Long-term changes in premature death of lung cancer in a developed region of China: a population-based study from 1973 to 2019 (Preprint)

2021 ◽  
Author(s):  
Wenjing Ye ◽  
Weiwei Lu ◽  
Xiaopan Li ◽  
Yichen Chen ◽  
Lin Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mortality Rate ◽  
Total Population ◽  
Demographic Factors ◽  
Premature Death ◽  
Years Of Life Lost ◽  
Registration System ◽  
Long Term Changes ◽  
Epidemiological Characteristics

BACKGROUND Lung cancer is the leading cause of cancer deaths worldwide, with 2,206,771 new lung cancer cases and 1,796,144 deaths in 2020. Many studies showed tremendous effort in the discovery of potential biomarkers for the detection, classification and progression monitoring of lung cancer. The treatment of lung cancer has made great progress over the past decade. The study on the long-term changes of disease burden of lung cancer has great exploratiory significance to further clarify the epidemiological characteristics of lung cancer and improve the survival time of patients OBJECTIVE The study in the long-term changes in premature death of lung cancer in a developed region of China has a great exploratiory significance to further clarify the effectiveness of intervention measures METHODS Cancer death data were collected from the Mortality Registration System of Shanghai Pudong New Area (PNA). We analysed crude mortality rate (CMR), age-standardized mortality rate by Segi’s world standard population (ASMRW), and years of life lost (YLL) of lung cancer from 1973 to 2019. Temporal trends of CMR, ASMRW, and rate of YLL were calculated by joinpoint regression expressed as an annual percent change (APC) with corresponding 95% confidence interval. RESULTS 80,543,137 person-years were enrolled in this study in PNA from 1973 to 2019. There were 42,229 deaths in permanent residents from lung cancer. The CMR and ASMRW were 52.43/105 person-years and 27.79/105 person-years. YLL due to premature death from lung cancer was 481779.14 years, and the rate of YLL was 598.16/105 person-years. The CMR, and rate of YLL for deaths had significantly increasing trends in males, females, and the total population (P<0.001). The CMR in the total population increased by 2.86% (95% CI=2.66%-3.07%, P < 0.001) per year during the study period. The YLL rate increased with an APCC of 2.21% (95% CI = 1.92% to 2.51%, P < 0.001) per year. The contribution rates of increased values of CMR caused by demographic factors were more evident than non-demographic factors. CONCLUSIONS The aging population, progress of treatment, smoking, and even environmental pollution may be the factors that affect the long-term changes in premature death of lung cancer in PNA from1973 to 2019. Our research can help us to understand the changes of lung cancer mortality, and our results could also be used for other similar cities in designing future prevention plans.

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