scholarly journals Decreased Serum Selenium Levels of COVID-19 Patients in Comparison with Healthy Individuals

Author(s):  
Ommolbanin Younesian ◽  
Behnaz Khodabakhshi ◽  
Nafiseh Abdolahi ◽  
Alireza Norouzi ◽  
Nasser Behnampour ◽  
...  
2010 ◽  
Vol 6 (2) ◽  
pp. 227
Author(s):  
Mutaz Suyagh ◽  
Peter Sedman ◽  
Prashant Jain ◽  
El-Naseer Salim ◽  
Khaled Hamdan

2010 ◽  
Vol 345 (1-2) ◽  
pp. 23-27 ◽  
Author(s):  
Barbara Kutil ◽  
Petr Ostadal ◽  
Jiri Vejvoda ◽  
Jiri Kukacka ◽  
Jana Cepova ◽  
...  

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 991
Author(s):  
Emilia Rogoża-Janiszewska ◽  
Karolina Malińska ◽  
Piotr Baszuk ◽  
Wojciech Marciniak ◽  
Róża Derkacz ◽  
...  

Melanoma is one of the most aggressive human malignancies. The determination of prognostic biomarkers is important for the early detection of recurrence and for the enrollment of the patients into different treatment regimens. Herein, we report the 10-year survival of 375 melanoma patients depending on their serum selenium levels. The study group was followed up from the date of melanoma diagnosis until death or 2020. Patients were assigned to one of four categories, in accordance with the increasing selenium level (I–IV quartiles). The subgroup with low selenium levels had a significant lower survival rate in relation to patients with high selenium levels, HR = 8.42; p = 0.005 and HR = 5.83; p = 0.02, for uni- and multivariable models, respectively. In the univariable analysis, we also confirmed the association between Breslow thickness, Clark classification and age at melanoma prognosis. In conclusion, a low serum selenium level was associated with an increased mortality rate in the 10 years following melanoma diagnosis. Future studies in other geographic regions with low soil selenium levels should be conducted to confirm our findings.


The Prostate ◽  
2018 ◽  
Vol 78 (4) ◽  
pp. 279-288 ◽  
Author(s):  
Dede N. Ekoue ◽  
Emmanuel Ansong ◽  
Li Liu ◽  
Virgilia Macias ◽  
Ryan Deaton ◽  
...  

1982 ◽  
Vol 15 (6) ◽  
pp. 281-283 ◽  
Author(s):  
Jan Aaseth ◽  
Jan Alexander ◽  
Yngvar Thomassen ◽  
Jan P. Blomhoff ◽  
Sverre Skrede

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1844 ◽  
Author(s):  
Soon Bo Choi ◽  
Yun Tae Jung ◽  
Jae Gil Lee

Low serum selenium levels are commonly observed in critically injured multiple trauma patients. This study aimed to identify the association between initial serum selenium levels and in-hospital infectious complications in multiple trauma patients. We retrospectively reviewed multiple trauma patients admitted between January 2015 and November 2017. We selected 135 patients whose serum selenium levels were checked within 48 h of admission. Selenium deficiency was defined as a serum selenium level <70 ng/mL. Survival analyses of selenium deficiency and 30-day mortality were performed. Multivariate logistic regression analysis was performed to identify the association between initial serum selenium level and in-hospital infectious complications. Thirty-day mortality (8.3% vs. 0.0%; p = 0.018) and incidence rates of pneumonia (66.7% vs. 28.3%; p < 0.001) and infectious complications (83.3% vs. 46.5%; p < 0.001) were higher in patients with selenium deficiency than in patients without selenium deficiency. Kaplan–Meier survival cures also showed similar results (log rank test, p = 0.021). Of 135 patients, 76 (56.3%) experienced at least one infectious complication during admission. High injury severity score (ISS, odds ratio (OR) 1.065, 95% confidence interval (CI) 1.024–1.108; p = 0.002) and selenium deficiency (OR 3.995, 95% CI 1.430–11.156; p = 0.008) increased the risk of in-hospital infectious complications in multiple trauma patients. Patients with selenium deficiency showed higher 30-day mortality and higher risks of pneumonia and infectious complications.


PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0238263
Author(s):  
Stephen Chijioke Eze ◽  
Nathan Azubuike Ododo ◽  
Emmanuel Onyebuchi Ugwu ◽  
Joseph Tochukwu Enebe ◽  
Onyema Athanatius Onyegbule ◽  
...  

1995 ◽  
Vol 47 (1-3) ◽  
pp. 355-364 ◽  
Author(s):  
W. -C. Wang ◽  
A. -L. Mäkelä ◽  
V. Näntö ◽  
P. Mäkelä

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 10061-10061
Author(s):  
N. Tacyildiz ◽  
T. Ucar ◽  
D. Ozyoruk ◽  
G. Yavuz ◽  
E. Unal ◽  
...  

10061 Background: High cumulative doses of an anthracyclin (300–500 mg/m2) are used in the several treatment protocols of children with Cancer. Probrain natriuretic peptit (Pro-BNP), is relased by cardiac cells and elevated even before overt cardiac distress symptoms. Selenium, is an antioxidant which its’ absence cause cardiomyopathy in people living in the poor selenium soil area. Aim 1: Assesment of anthracycline-induced cardiotoxicity with Pro-BNP levels, correlated with echo-cardiographic (ECHO) findings. Aim 2: Determine possible effects of selenium levels and supplemantation on cardiac toxicity. Methods: Plasma levels of Pro-BNP have been measured in 58 pediatric cancer patients (leukemias, lymphomas,solid tumors; 38 boys, 20 girls; between 2–18 years, median:12) after completed their anthracycline containing regimens. Serum selenium levels examined in 12 patients (six patients were with high and other six with normal pro-BNP levels). Three of four Patients with low level of selenium showed cardiac failure according to ECHO and supplemanted with selenium besides digoxine, ACE inhibitors. Results: Eleven patients have found with high pro-BNP levels (120–8022 pg/ml; normal: lower than 120 pg/ml).Six of these patients (with 170–8022 pg/ml, median:798pg/ml pro-BNP) and other six patients with normal levels of pro-BNP (10–74pg/ml, median: 67pg/ml) examined for their serum selenium levels. All patients with normal pro-BNP levels have found in normal levels of selenium levels (71–150 μg/L,median:125 μg/L). Four patients in high pro-BNP group showed low levels of selenium (52–129 μg/L; median:67.5 μg/L). Since three of that four patients have cardiac failure, treated accordingly and supplemented with 100 μg/day selenium to maintain normal levels. During follow-up periods of 27; 8 and 2 months, all 3 patients are doing well with normal ECHO finding. Two patients reached normal Pro-BNP levels while one of them has 80 % decrease. Conclusions: Serum Pro-BNP levels can be used as a marker for anthracycline toxicity and as follow-up marker for protective agents. Selenium suplemantation may have a potential role to protect and/or overcome the difficulties related anthracyclin-induced toxicities. No significant financial relationships to disclose.


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