Association of Matrix Metalloproteinase-2 (MMP-2) and MMP-9 Promoter Polymorphisms, Their Serum Levels, and Activities with Coronary Artery Calcification (CAC) in an Iranian Population

2021 ◽  
Author(s):  
Saeed Elahirad ◽  
Daniel Elieh Ali Komi ◽  
Amir Kiani ◽  
Ehsan Mohammadi-Noori ◽  
Asad Vaisi‑Raygani ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Matrix Metalloproteinase ◽  
Coronary Artery Calcification ◽  
Serum Levels ◽  
Iranian Population ◽  
Matrix Metalloproteinase 2 ◽  
Promoter Polymorphisms

Association between Vitamins and Minerals with Antioxidant Effects and Coronary Artery Calcification in Adults and Older Adults: A Systematic Review

2019 ◽  
Vol 25 (22) ◽  
pp. 2474-2479 ◽  
Author(s):  
Alisson Diego Machado ◽  
Gustavo Rosa Gentil Andrade ◽  
Jéssica Levy ◽  
Sara Silva Ferreira ◽  
Dirce Maria Marchioni
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Serum Levels ◽  
Antioxidant Compounds ◽  
Increased Risk ◽  
Coronary Events ◽  
Antioxidant Effects

Background: Coronary Artery Calcification (CAC) is considered an important cardiovascular risk factor. There is evidence that CAC is associated with an increased risk of atherosclerosis, coronary events and cardiovascular mortality. Inflammation is one of the factors associated with CAC and despite the interest in antioxidant compounds that can prevent CAC, its association with antioxidants remains unclear. Objective: This study aimed to systematically review the association between vitamins and minerals with antioxidant effects and CAC in adults and older adults. Methods: We conducted a systematic review using PubMed for articles published until October 2018. We included studies conducted in subjects aged 18 years and older with no previous cardiovascular disease. Studies involving animal or in vitro experiments and the ones that did not use reference methods to assess the CAC, dietary intake or serum levels of vitamin or mineral were excluded. Results: The search yielded 390 articles. After removal of duplicates, articles not related to the review, review articles, editorials, hypothesis articles and application of the inclusion and exclusion criteria, 9 articles remained. The results of the studies included in this systematic review suggest that magnesium is inversely associated with CAC and results on the association between CAC and vitamin E have been conflicting. Conclusion: Additional prospective studies are needed to elucidate the role of these micronutrients on CAC.

scholarly journals Serum levels and tissue expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinases 2 (TIMP-2) in colorectal cancer patients

Tumor Biology ◽  
2014 ◽  
Vol 35 (4) ◽  
pp. 3793-3802 ◽  
Author(s):  
Magdalena Groblewska ◽  
Barbara Mroczko ◽  
Mariusz Gryko ◽  
Anna Pryczynicz ◽  
Katarzyna Guzińska-Ustymowicz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Patients ◽  
Serum Levels ◽  
Tissue Expression ◽  
Matrix Metalloproteinase 2 ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Tissue Inhibitor ◽  
Colorectal Cancer Patients

scholarly journals Serum levels of matrix metalloproteinase-2 in patients with oral submucous fibrosis and oral squamous cell carcinoma

2020 ◽  
Vol 8 (2) ◽  
pp. 636
Author(s):  
Pooja Kherde ◽  
Suchitra Gosavi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Matrix Metalloproteinase ◽  
Healthy Subjects ◽  
Oral Submucous Fibrosis ◽  
Positive Association ◽  
Serum Levels ◽  
Matrix Metalloproteinase 2 ◽  
Submucous Fibrosis ◽  
The Mean

Background: Matrix metalloproteinase-2 (MMP-2), which is supposed to enable cancer cells cross the basement membrane and metastasize by selectively cleaving type IV collagen, is anticipated to be a good diagnostic and prognostic marker in oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSMF). Thus, the study is aimed to estimate and compare the serum MMP-2 levels in patients with OSMF and OSCC.Methods: The study was conducted on 88 subjects, divided into three groups; Group I (healthy subjects, n=28), Group II (patients with OSMF, n=30), and Group III (patients with OSCC, n=30). Serum levels of MMP-2 were estimated and compared among the groups and further with the clinical parameters within the groups.Results: The mean serum MMP-2 levels in patients with OSMF (2.87±1.04 ng/mL) and with OSCC (11.55±2.16 ng/mL) were significantly higher than the healthy subjects (0.93±0.26 ng/mL) (p <0.0001, for both). Furthermore, the mean serum MMP-2 levels in OSMF subjects had a positive association with inter-incisal opening (IIO), however, there was no association with the degree of burning sensation. Likewise, in subjects with OSCC, levels of serum MMP-2 showed positive association with histopathological grades, however, significant association with the site of occurrence and primary tumor size was not found.Conclusions: Elevated serum MMP-2 levels can be used as a screening tool in the early detection of OSMF and OSCC cases. Moreover, MMP-2 might be a good marker in evaluating the tumor grade in OSCC and the IIO in OSMF.

Investigating the Association of Matrix Metalloproteinase-2 Gene Variants with Endometriosis in an Iranian Population

2020 ◽  
Author(s):  
Saeedeh Ebrahimi Tarki ◽  
Iman Salahshouri Far ◽  
Soheila Aminimoghaddam ◽  
Bahareh Fooladi ◽  
Negar Sarhangi ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Iranian Population ◽  
Matrix Metalloproteinase 2 ◽  
Gene Variants

scholarly journals Serum levels of matrix metalloproteinase-2, -9, and vitamin D in patients with multiple sclerosis with or without herpesvirus-6 seropositivity

2020 ◽  
Vol 24 (2) ◽  
pp. 144-149
Author(s):  
Razieh Amini ◽  
Sajad karampoor ◽  
Hamid Zahednasab ◽  
Hossein Keyvani ◽  
Masoud Gheiasian ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Matrix Metalloproteinase ◽  
Serum Levels ◽  
Matrix Metalloproteinase 2 ◽  
Herpesvirus 6
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