scholarly journals Osteocalcin carboxylation is not associated with body weight or percent fat changes during weight loss in post-menopausal women

Endocrine ◽  
2015 ◽  
Vol 50 (3) ◽  
pp. 627-632 ◽  
Author(s):  
Amanda J. Centi ◽  
Sarah L. Booth ◽  
Caren M. Gundberg ◽  
Edward Saltzman ◽  
Barbara Nicklas ◽  
...  
2016 ◽  
Vol 20 (6) ◽  
pp. 510-516 ◽  
Author(s):  
Maude Dulac ◽  
Guy El Hajj Boutros ◽  
Charlotte Pion ◽  
Sébastien Barbat-Artigas ◽  
Gilles Gouspillou ◽  
...  

2021 ◽  
Author(s):  
Sara Santini ◽  
Nathalie Vionnet ◽  
Jérôme Pasquier ◽  
Michel Suter ◽  
Didier Hans ◽  
...  

Objective: Bariatric surgery (BS) induces loss of body fat mass (FM) with an inexorable loss of lean mass (LM). Menopause leads to deleterious changes in body composition (BC) related to estrogen deficiency including LM loss and increase in total and visceral adipose tissue (VAT). This study aims to describe long-term weight evolution of post-menopausal women after RYGB (Roux-en-Y gastric bypass) and to compare BC between BS patients versus post-menopausal non-operated women. Design: Cross-sectional study of 60 post-menopausal women who underwent RYGB ≥ two years prior to the study with nested case-control design. Methods: Post-menopausal BS women were matched for age and BMI with controls. Both groups had DXA scan, lipids and glucose metabolism markers assessment. Results: Median follow-up was 7.5(2–18) years. Percentage of total weight loss (TWL%) was 28.5±10%. After RYGB, LM percentage of body weight (LM%) was positively associated with TWL% and negatively associated with nadir weight. Forty-one post-BS women were matched with age- and BMI-controls. Post-BS patients showed higher LM% (57.7%[±8%] versus 52.5%[±5%], p=0.001), reduced FM% (39.4%[±8.4%] versus 45.9%[±5.4%] p<0.01) and lower VAT (750.6g[±496] versus 1295.3g[±688], p<0.01) with no difference in absolute LM compared to controls. While post-BS women showed a better lipid profile compared to controls, no difference was found in glucose markers. Conclusions: Post-menopausal women after RYGB have a lower FM and VAT, preserved LM and a better lipid profile compared to controls. Weight loss after RYGB seems to have a persistent positive impact on metabolic health.


Appetite ◽  
2013 ◽  
Vol 60 ◽  
pp. 111-116 ◽  
Author(s):  
Jameason D. Cameron ◽  
Marie-Ève Riou ◽  
Frédérique Tesson ◽  
Gary S. Goldfield ◽  
Rémi Rabasa-Lhoret ◽  
...  

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 12076-12076
Author(s):  
Anna-Carson Rimer Uhelski ◽  
David Lim ◽  
Amanda L. Blackford ◽  
Jennifer Y. Sheng ◽  
Claire Frances Snyder ◽  
...  

12076 Background: Weight gain is common after a breast cancer diagnosis. The incidence of and risk factors for weight gain during adjuvant endocrine therapy (ET) are poorly described. Limited data support an association between emergent symptoms and weight gain after a breast cancer diagnosis. Methods: We enrolled women with stage 0-III breast cancer initiating ET in a prospective clinic-based cohort. We assessed symptoms with the FACT-ES and PROMIS pain interference, depression, anxiety, fatigue, sleep disturbance and physical function measures at baseline (BL), 3, 6, 12, 24, 36, 48 and 60 months (mo). We defined emergent symptoms at 3 and/or 6 mo as worsening of 4 points from BL on PROMIS measures and 5 points from BL on the FACT-ES. We abstracted weight and menopausal status from charts. The primary outcome of this secondary analysis was weight gain (dichotomized as ≥5% vs < 5% of body weight compared to BL) through 60 mo. We evaluated the association between weight gain during ET and menopausal status. We also evaluated the associations between clinicodemographic factors and emergent symptoms with weight gain and if these associations differed by menopausal status. We performed logistic regression modeling with GEE to account for the longitudinal design. We identified a multivariable model for the set of factors associated with weight gain among pre-menopausal women taking ET. Results: 309 of 321 participants with BL and ≥1 follow-up (FU) weight were included. 263 (85%) had stage I-II disease, 99 (32%) were pre-menopausal, 259 (84%) were White and 32 (10%) were Black. Prior to ET, 45% had mastectomy, 66% had radiation, and 28% received chemotherapy. 4% of pre- and 82% of post-menopausal participants initiated an aromatase inhibitor (AI); all others initiated tamoxifen (Tam). 17% of pre-menopausal participants received ovarian suppression. At BL, 75% of Black and 59% of White participants were overweight/obese. With a median FU of 56 mo, 51% of pre- and 34% of post-menopausal participants gained ≥5% body weight (OR 1.09, 95% CI 1.07-1.13, p < 0.001). For each PRO measure, > 20% of participants had emergent symptoms. Worsening of physical function and pain interference scores at 3 and/or 6 mo were differentially associated with weight gain according to menopausal status (interaction p-values ≤0.05). On multivariate analysis, factors associated with weight gain among pre-menopausal participants were ET (AI vs Tam) (OR 2.8, 95% CI 0.90- 8.77, p = 0.08), prior mastectomy (OR 2.06, 95% CI 0.89-4.77, p = 0.09), emergent pain interference (OR 2.49, 95% CI 0.99-6.24, p = 0.05) and race (White vs other) (OR 7.13, 95% CI 1.29-39.4], p = 0.02). Conclusions: Weight gain during ET for breast cancer is more frequent among pre-menopausal than post-menopausal women. Worsening pain soon after ET initiation, receipt of AI, prior mastectomy and race may identify pre-menopausal women at risk for weight gain for whom prevention strategies are a priority.


1997 ◽  
Vol 75 (6) ◽  
pp. 910-913 ◽  
Author(s):  
RA Badwe ◽  
IS Fentiman ◽  
RR Millis ◽  
WM Gregory

Bone ◽  
1995 ◽  
Vol 16 (6) ◽  
pp. 694
Author(s):  
S. Suleiman ◽  
C. Moniz ◽  
M. Buxton-Thomas

Author(s):  
Sawai Singh ◽  
Ram Chander

Background: To determine the usefulness of risk assessment and screening for osteoporosis in a hospital based population of postmenopausal women. Methods: 100 women with post-menopausal women, age more than 40 yrs, cessation of period more than 1yr were included in the study. Result: 17 (17.0%) were more than 65 years of age. Low body weight, inadequate dietary intake of calcium and decreased physical activity were most commonly associated risk factor. 4 (4.0%) women were smokers, women had history of oral steroid intake for >3 months for various medical illnesses. Conclusion: Evaluation of postmenopausal women by screening for risk factors was found to be a powerful tool to define the risk status for osteoporosis. Low body weight and poor dietary calcium are modifiable risk factors for developing osteoporosis. Keywords: Osteoporosis, Post-Menopausal, Prevalence  


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