scholarly journals Two-hour postload glycemia is associated to an increased risk of NAFLD in healthy subjects with family history of type 2 diabetes: a case control study

Endocrine ◽  
2016 ◽  
Vol 57 (2) ◽  
pp. 352-355
Author(s):  
Nadia Pallotta ◽  
Tiziana Filardi ◽  
Anna Carnovale ◽  
Luciano Nieddu ◽  
Paola Mariani ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Healthy Subjects ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
History Of ◽  
Control Study

scholarly journals Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jaime Berumen ◽  
Lorena Orozco ◽  
Miguel Betancourt-Cravioto ◽  
Héctor Gallardo ◽  
Mirella Zulueta ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Parental History ◽  
History Of ◽  
Parental History Of Diabetes ◽  
Control Study

scholarly journals Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case–control study and meta-analysis

2010 ◽  
Vol 163 (3) ◽  
pp. 427-434 ◽  
Author(s):  
José Miguel Dora ◽  
Walter Escouto Machado ◽  
Jakeline Rheinheimer ◽  
Daisy Crispim ◽  
Ana Luiza Maia
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Association Studies ◽  
Meta Analysis ◽  
Genetic Association Studies ◽  
Case Control ◽  
Increased Risk ◽  
Key Enzyme ◽  
Control Study

ObjectiveThe type 2 deiodinase (D2) is a key enzyme for intracellular triiodothyronine (T3) generation. A single-nucleotide polymorphism in D2 (Thr92Ala) has been associated with increased insulin resistance in nondiabetic and type 2 diabetes (DM2) subjects. Our aim was to evaluate whether the D2 Thr92Ala polymorphism is associated with increased risk for DM2.Design and methodsA case–control study with 1057 DM2 and 516 nondiabetic subjects was performed. All participants underwent genotyping of the D2 Thr92Ala polymorphism. Additionally, systematic review and meta-analysis of the literature for genetic association studies of D2 Thr92Ala polymorphism and DM2 were performed in Medline, Embase, LiLacs, and SciELO, and major meeting databases using the terms ‘rs225014’ odds ratio (OR) ‘thr92ala’ OR ‘T92A’ OR ‘dio2 a/g’.ResultsIn the case–control study, the frequencies of D2 Ala92Ala homozygous were 16.4% (n=173) versus 12.0% (n=62) in DM2 versus controls respectively resulting in an adjusted OR of 1.41 (95% confidence intervals (CI) 1.03–1.94, P=0.03). The literature search identified three studies that analyzed the association of the D2 Thr92Ala polymorphism with DM2, with the following effect estimates: Mentuccia (OR 1.40 (95% CI 0.78–2.51)), Grarup (OR 1.09 (95% CI 0.92–1.29)), and Maia (OR 1.22 (95% CI 0.78–1.92)). The pooled effect of the four studies resulted in an OR 1.18 (95% CI 1.03–1.36, P=0.02).ConclusionsOur results indicate that in a case–control study, the homozygosity for D2 Thr92Ala polymorphism is associated with increased risk for DM2. These results were confirmed by a meta-analysis including 11 033 individuals, and support a role for intracellular T3 concentration in skeletal muscle on DM2 pathogenesis.

scholarly journals Egg consumption and the risk of type 2 diabetes mellitus: a case–control study

2012 ◽  
Vol 15 (8) ◽  
pp. 1437-1441 ◽  
Author(s):  
Lina Radzevičienė ◽  
Rytas Ostrauskas
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Case Control Study ◽  
Case Control ◽  
Egg Consumption ◽  
Increased Risk ◽  
Control Study

AbstractObjectiveType 2 diabetes mellitus appears to involve an interaction between susceptible genetic backgrounds and environmental factors including highly calorific diets. As it is important to identify modifiable risk factors that may help reduce the risk of type 2 diabetes mellitus, the aim of the present study was to determine the association between egg consumption and the risk of type 2 diabetes mellitus.DesignA specifically designed questionnaire was used to collect information on possible risk factors of type 2 diabetes mellitus. The odds ratios and 95 % confidence intervals for type 2 diabetes mellitus were calculated by conditional logistic regression.SettingA case–control study in a Lithuanian out-patient clinic was performed in 2001.SubjectsA total of 234 cases with a newly confirmed diagnosis of type 2 diabetes mellitus and 468 controls free of the disease.ResultsVariables such as BMI, family history of diabetes, cigarette smoking, education, morning exercise and plasma TAG level were retained in multivariate logistic regression models as confounders because their inclusion changed the value of the odds ratio by more than 10 % in any exposure category. After adjustment for possible confounders more than twofold increased risk of type 2 diabetes mellitus was determined for individuals consuming 3–4·9 eggs/week (OR = 2·60; 95 % CI 1·34, 5·08) and threefold increased risk of the disease was determined for individuals consuming ≥5 eggs/week (OR = 3·02; 95 % CI 1·14, 7·98) compared with those eating <1 egg/week.ConclusionsOur data support a possible relationship of egg consumption and increased risk of type 2 diabetes mellitus.

scholarly journals Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case–control study

Diabetologia ◽  
2015 ◽  
Vol 58 (11) ◽  
pp. 2525-2532 ◽  
Author(s):  
Rebecka Hjort ◽  
Lars Alfredsson ◽  
Per-Ola Carlsson ◽  
Leif Groop ◽  
Mats Martinell ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Low Birthweight ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
Control Study

scholarly journals Autoantibodies against PFDN2 are associated with an increased risk of type 2 diabetes: A case-control study

2017 ◽  
Vol 33 (8) ◽  
pp. e2922 ◽  
Author(s):  
Douglas C. Chang ◽  
Paolo Piaggi ◽  
Robert L. Hanson ◽  
William C. Knowler ◽  
Clifton Bogardus ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
Control Study

scholarly journals Diabetic dyslipidemia and type 2 diabetes mellitus as early as six weeks post-partum: a nested case control study

2021 ◽  
Vol 8 (6) ◽  
pp. 3116
Author(s):  
Meesha Iqbal ◽  
Paramjit Gill ◽  
Iqbal Azam ◽  
Romaina Iqbal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Case Control Study ◽  
Post Partum ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Increased Risk ◽  
Control Study

Women who develop diabetes during pregnancy (Gestational diabetes mellitus-GDM) increase their risk of developing type 2 diabetes mellitus (T2DM) post-partum by 70%. The average time to develop T2DM varies and is not widely studied. T2DM is associated with increased risk of developing dyslipidemia leading to cardiovascular diseases. We intended to study the association of dyslipidemia and T2DM as early as 6 weeks post-partum. A matched case control study was designed, and conditional logistic regression analysis applied to get adjusted matched odds with 95% confidence intervals. Our study revealed increased serum LDL levels in the cases compared to the controls (p=0.03). However, no association was seen with other lipid parameters. 

scholarly journals An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Renata Suchanek-Raif ◽  
Paweł Raif ◽  
Małgorzata Kowalczyk ◽  
Monika Paul-Samojedny ◽  
Aleksandra Zielińska ◽  
...  
Keyword(s):  
Family History ◽  
Case Control Study ◽  
Suicide Attempts ◽  
Five Factor Model ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Increased Risk ◽  
Polymorphic Genotype ◽  
History Of ◽  
Control Study

Aim. The BDNF dysfunction in the schizophrenia has been soundly documented. The TrkB gene is a high-affinity receptor of the BDNF that is changed in schizophrenia and mood disorders. The study had two aims: first, to identify whether the five nucleotide polymorphisms (SNPs) in TrkB gene are associated with a diagnosis of schizophrenia; and the latter, if any association exists between the TrkB SNPs and psychopathology, suicide attempts, and family history of schizophrenia in a Caucasian population. Methods. Case-control study (401 patients and 657 healthy controls) was used to examine a predisposition for schizophrenia. The tests for psychopathology, suicide attempts, and family history of schizophrenia were conducted only in patient group. The severity of the schizophrenia was measured using the five-factor model of the PANSS. In addition, the haplotype analysis for both the separate for SNPs of TrkB gene and in combination with the rs6265 SNP BDNF gene was conducted. Results. Our case-control study revealed that the genetic variants of rs10868235 (T/T polymorphic genotype) and rs1387923 (G/G polymorphic genotype) of the TrkB gene were associated with a higher risk of developing schizophrenia in men. However, the A/A wild genotype of rs1387923 was connected with a lower risk for both the development of and the family manifestation of schizophrenia in men. The G polymorphic allele of rs1565445 was associated with an increased risk of suicide in schizophrenia. The tested SNPs of the TrkB gene did not modulate the psychopathology of schizophrenia. The haplotype that was built with five SNPs in the TrkB gene was protective for men, but after joining the rs6265 SNP of the BDNF gene, a haplotype that was protective for women was created.

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