scholarly journals Accuracy of recommended sampling and assay methods for the determination of plasma-free and urinary fractionated metanephrines in the diagnosis of pheochromocytoma and paraganglioma: a systematic review

Endocrine ◽  
2017 ◽  
Vol 56 (3) ◽  
pp. 495-503 ◽  
Author(s):  
Roland Därr ◽  
Matthias Kuhn ◽  
Christoph Bode ◽  
Stefan R. Bornstein ◽  
Karel Pacak ◽  
...  
Keyword(s):  
Systematic Review ◽  
Assay Methods

EXPRESS: Method dependent variation in TSH and FT4 reference intervals in pregnancy: a systematic review

2021 ◽  
pp. 000456322110269
Author(s):  
O E Okosieme ◽  
Medha Agrawal ◽  
Danyal Usman ◽  
Carol Evans
Keyword(s):  
Systematic Review ◽  
Reference Interval ◽  
First Trimester ◽  
Reference Intervals ◽  
Assay Method ◽  
Specific Reference ◽  
Upper Limits ◽  
Wide Range ◽  
Assay Methods ◽  
In Pregnancy

Background: Gestational TSH and FT4 reference intervals may differ according to assay method but the extent of variation is unclear and has not been systematically evaluated. We conducted a systematic review of published studies on TSH and FT4 reference intervals in pregnancy. Our aim was to quantify method-related differences in gestation reference intervals, across four commonly used assay methods, Abbott, Beckman, Roche, and Siemens. Methods: We searched the literature for relevant studies, published between January 2000 and December 2020, in healthy pregnant women without thyroid antibodies or disease. For each study, we extracted trimester-specific reference intervals (2.5–97.5 percentiles) for TSH and FT4 as well as the manufacturer provided reference interval for the corresponding non-pregnant population. Results: TSH reference intervals showed a wide range of study-to-study differences with upper limits ranging from 2.33 to 8.30 mU/L. FT4 lower limits ranged from 4.40–13.93 pmol/L, with consistently lower reference intervals observed with the Beckman method. Differences between non-pregnant and first trimester reference intervals were highly variable, and for most studies the TSH upper limit in the first trimester could not be predicted or extrapolated from non-pregnant values. Conclusions: Our study confirms significant intra and inter-method disparities in gestational thyroid hormone reference intervals. The relationship between pregnant and non-pregnant values is inconsistent and does not support the existing practice in some laboratories of extrapolating gestation references from non-pregnant values. Laboratories should invest in deriving method-specific gestation reference intervals for their population.

A Systematic Review of Replicative Self-Determination Intervention Studies

2019 ◽  
Vol 54 (1) ◽  
pp. 29-39
Author(s):  
John L. Luckner ◽  
Rashida Banerjee ◽  
Sara Movahedazarhouligh ◽  
Kaitlyn Millen
Keyword(s):  
Systematic Review ◽  
Intervention Studies ◽  
Self Determination ◽  
Future Research ◽  
Replication Studies ◽  
Research Designs ◽  
Replication Research ◽  
Quality Of Research

Current federal legislation emphasizes the use of programs, interventions, strategies, and activities that have been demonstrated through research to be effective. One way to increase the quantity and quality of research that guides practice is to conduct replication research. The purpose of this study was to undertake a systematic review of the replication research focused on self-determination conducted between 2007 and 2017. Using methods used by Cook and colleagues, we identified 80 intervention studies on topics related to self-determination, of which 31 were coded as replications. Intervention study trends, rate of replication studies, percentage of agreements between findings of original and replication studies, amount of author overlap, and types of research designs used are reported along with recommendations for future research.

scholarly journals Assessment of antibody assay methods in determination of prevalence of infectious bursal disease among local chickens and guinea fowls in Kwara state, North Central Nigeria

2018 ◽  
Vol 11 (8) ◽  
pp. 1183-1187 ◽  
Author(s):  
Oluwafemi Babatunde Daodu ◽  
Oladapo Oyedeji Oludairo ◽  
Julius Olaniyi Aiyedun ◽  
Hauwa Motunrayo Ambali ◽  
Rafiu Adebisi Kadir ◽  
...  
Keyword(s):  
Infectious Bursal Disease ◽  
Antibody Assay ◽  
North Central ◽  
Bursal Disease ◽  
Assay Methods ◽  
Local Chickens

RP-HPLC AND HPTLC STABILITY INDICATING ASSAY METHODS FOR IVERMECTIN IN BULK AND TABLET DOSAGE FORM

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (03) ◽  
pp. 32-42
Author(s):  
G. P Wani ◽  
◽  
S. B Jadhav
Keyword(s):  
Mobile Phase ◽  
Stress Testing ◽  
Hplc Method ◽  
Rp Hplc ◽  
Assay Methods ◽  
Photo Stability ◽  
Tablet Dosage ◽  
Hptlc Method ◽  
Alkaline Oxidation

Simple, rapid, precise, accurate RP-HPLC and HPTLC methods have been developed and validated for ivermectin in bulk and its marketed formulation. RP-HPLC method for drug was achieved on Grace C18 (250 mm X 4.6 ID, Particle size; 5 μ) column using mobile phase acetonitrile: 10 mM phosphate buffer (95:05 v/v) pH adjusted to 3 with o-phosphoric acid. Detection of drug was done at 245 nm. The retention time was found to be 5.83 min. HPTLC method for ivermectin was accomplished on a precoated silica gel aluminium plate 60F-254 (CAMAG Linomat 5), using toluene: methanol: glacial acetic acid (8:2:0.1 v/v/v) as a mobile phase. The densitometric scanning was performed at 245 nm which showed Rf 0.46 for ivermectin. The stress testing of the drug individually was carried out under acidic, alkaline, oxidation, photo-stability and thermal degradation conditions. The proposed methods were successfully applied for the determination of drug in bulk and its marketed formulation.

Review of the genus Abiskomyia Edwards (Diptera: Chironomidae: Orthocladiinae), with description of new taxa from the Russian Far East and bordering territories

Zootaxa ◽  
2015 ◽  
Vol 3919 (1) ◽  
pp. 41 ◽  
Author(s):  
EUGENYI A. MAKARCHENKO ◽  
MARINA A. MAKARCHENKO
Keyword(s):  
Systematic Review ◽  
New Species ◽  
New Taxa ◽  
Russian Far East ◽  
Far East ◽  
Fourth Instar ◽  
Adult Males ◽  
Three New Species ◽  
The Russian Far East

A systematic review of the genus Abiskomyia Edwards, 1937 is presented based on materials from the Russian Far East and bordering territories. Three new species: A. korbokhon sp. nov., A. levanidovi sp. nov., A. rivalis sp. nov. and one subspecies A. virgo orientalis subsp. nov. are described and figured. Emended generic diagnoses and keys to determination of adult males, pupae and fourth instar larvae of all known species and subspecies of the Abiskomyia of the Palaearctic region are provided. 

scholarly journals Determination of Biotin and Folate in Infant Formula and Milk by Optical Biosensor-Based Immunoassay

2000 ◽  
Vol 83 (5) ◽  
pp. 1141-1148 ◽  
Author(s):  
Harvey E Indyk ◽  
Eileen A Evans ◽  
Malin C Bostrom Caselunghe ◽  
Bjorn S Persson ◽  
Paul M Finglas ◽  
...  
Keyword(s):  
Interaction Analysis ◽  
Automated Analysis ◽  
Optical Biosensor ◽  
Cross Reactivity ◽  
Biomolecular Interaction ◽  
Technology Standard ◽  
Sample Extraction ◽  
Relative Standard ◽  
Assay Methods

Abstract Biomolecular interaction analysis was evaluated for the automated analysis of biotin- and folate-supplemented infant formulas and milk powders. The technique was configured as a biosensor-based, nonlabeled inhibition immunoassay using monoclonal antibodies raised against analyte-conjugate. Sample extraction conditions were optimized and antibodies were evaluated for cross-reactivity. Performance parameters included a quantitation range of 2–70 ng/mL, recoveries of 86–102%, agreement against assigned reference values for National Institute of Standards and Technology Standard Reference Material 1846, between-laboratory reproducibility relative standard deviation of 9.1% for biotin and 8.1% for folate, respectively, and equivalence against reference microbiological assay methods for both analytes.

scholarly journals Stability-Indicating Methods for Determination of Pyritinol Dihydrochloride in the Presence of Its Precursor and Degradation Product by Derivative Spectrophotometry

2005 ◽  
Vol 88 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Mostafa A Shehata ◽  
Mohammad A El-Sayed ◽  
Mohammad G El-Bardicy ◽  
Mohammad F El-Tarras
Keyword(s):  
Hydrochloric Acid ◽  
Degradation Product ◽  
Pharmaceutical Formulations ◽  
Zero Crossing ◽  
Stability Indicating ◽  
First Derivative ◽  
Linear Relationships ◽  
Assay Methods ◽  
Powdered Form

Abstract A first-derivative spectrophotometric (1D) method and a derivative-ratio zero-crossing spectrophotometric (1DD) method were used to determine pyritinol dihydrochloride (I) in the presence of its precursor (II) and its degradation product (III) with 0.1N hydrochloric acid as a solvet. Linear relationships were obtained in the ranges of 6–22 μg/mL for the (1D) method and 6–20 μg/mL for the (1DD) method. By applying the proposed methods, it was possible to determine pyritinol dihydrochloride in its pure powdered form with an accuracy of 100.36 ± 1.497% (n = 9) for the (1D) method and an accuracy of 99.92 ± 1.172% (n = 8) for the (1DD) method. Laboratory-prepared mixtures containing different ratios of (I), (II), and (III) were analyzed, and the proposed methods were valid for concentrations of ≤10% (II) and ≤50% (III). The proposed methods were validated and found to be suitable as stability-indicating assay methods for pyritinol in pharmaceutical formulations.

scholarly journals Should We Use Carbohydrate-deficient Transferrin instead of γ-Glutamyltransferase for Detecting Problem Drinkers? A Systematic Review and Metaanalysis

2000 ◽  
Vol 46 (12) ◽  
pp. 1894-1902 ◽  
Author(s):  
Kay Scouller ◽  
Katherine M Conigrave ◽  
Petra Macaskill ◽  
Les Irwig ◽  
John B Whitfield
Keyword(s):  
Systematic Review ◽  
Liquid Chromatography ◽  
Alcohol Use ◽  
Roc Analysis ◽  
Problem Drinkers ◽  
Excessive Alcohol Consumption ◽  
Carbohydrate Deficient Transferrin ◽  
Excessive Alcohol ◽  
Assay Methods ◽  
Better Than

Abstract Background: Carbohydrate-deficient transferrin (CDT) has been used as a test for excessive alcohol consumption in research, clinical, and medico-legal settings, but there remain conflicting data on its accuracy, with sensitivities ranging from <20% to 100%. We examined evidence of its benefit over a conventional and less expensive test, γ-glutamyltransferase (GGT), and compared the accuracy of different CDT assay methods. Methods: We performed a systematic review using summary ROC analysis of 110 studies prior to June 1998 on the use of CDT in the detection of alcohol dependence or hazardous/harmful alcohol use. Results: We identified several potential sources of bias in studies. In studies examining CDT and GGT in the same subjects, subject characteristics were less likely to influence the comparison. In such paired studies, the original Pharmacia CDT assay was significantly more accurate than GGT, but the modified CDTect assay did not perform as well as the original and was not significantly better than GGT. The accuracy of the AXIS %CDT assay was statistically indistinguishable from modified CDTect. Several CDT assay methods appeared promising, in particular, liquid chromatography (chromatofocusing, HPLC, fast protein liquid chromatography) and isoelectric focusing, but there were insufficient paired studies from which to draw firm conclusions. Conclusions: In studies published before June 1998, the results obtained with commercially available CDT assays were not significantly better than GGT as markers of excessive alcohol use in paired studies. Further high-quality studies comparing CDTect (modified) and other CDT assays with GGT in the same subjects are needed.

scholarly journals Inclusion, characteristics and outcomes of people requiring palliative care in studies of non-pharmacological interventions for delirium: A systematic review

2019 ◽  
Vol 33 (8) ◽  
pp. 878-899 ◽  
Author(s):  
Annmarie Hosie ◽  
Najma Siddiqi ◽  
Imogen Featherstone ◽  
Miriam Johnson ◽  
Peter G Lawlor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Palliative Care ◽  
Subjective Experience ◽  
Intervention Studies ◽  
Search Terms ◽  
Study Heterogeneity ◽  
Inpatient Settings ◽  
Almost All ◽  
Multicomponent Interventions

Background: Delirium is common, distressing, serious and under-researched in specialist palliative care settings. Objectives: To examine whether people requiring palliative care were included in non-pharmacological delirium intervention studies in inpatient settings, how they were characterised and what their outcomes were. Design: Systematic review (PROSPERO 2017 CRD42017062178). Data sources: Systematic search in March 2017 for non-pharmacological delirium intervention studies in adult inpatients. Database search terms were ‘delirium’, ‘hospitalisation’, ‘inpatient’, ‘palliative care’, ‘hospice’, ‘critical care’ and ‘geriatrics’. Scottish Intercollegiate Guidelines Network methodological checklists guided risk of bias assessment. Results: The 29 included studies were conducted between 1994 and 2015 in diverse settings in 15 countries (9136 participants, mean age = 76.5 years ( SD = 8.1), 56% women). Most studies tested multicomponent interventions ( n = 26) to prevent delirium ( n = 19). Three-quarters of the 29 included studies ( n = 22) excluded various groups of people requiring palliative care; however, inclusion criteria, participant diagnoses, illness severity and mortality indicated their presence in almost all studies ( n = 26). Of these, 21 studies did not characterise participants requiring palliative care or report their specific outcomes (72%), four reported outcomes for older people with frailty, dementia, cancer and comorbidities, and one was explicitly focused on people receiving palliative care. Study heterogeneity and limitations precluded definitive determination of intervention effectiveness and only allowed interpretations of feasibility for people requiring palliative care. Acceptability outcomes (intervention adverse events and patients’ subjective experience) were rarely reported overall. Conclusion: Non-pharmacological delirium interventions have frequently excluded and under-characterised people requiring palliative care and infrequently reported their outcomes.

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