Hidradenitis suppurativa and rheumatoid arthritis: evaluating the bidirectional association

AbstractDespite some common pathogenic themes, the association of hidradenitis suppurativa (HS) and rheumatoid arthritis (RA) has been poorly investigated. We aimed to evaluate the bidirectional association between HS and RA. A population-based study was conducted to compare HS patients (n = 6779) with age-, sex- and ethnicity-matched control subjects (n = 33,260) with regard to the incidence of new-onset and the prevalence of preexisting RA. Adjusted hazard ratios (HRs) and adjusted odds ratios (ORs) were estimated. The prevalence of preexisting RA was greater among patients with HS relative to controls (0.5% vs 0.3%. respectively; p = 0.019). The odds of being diagnosed with HS were 1.6-fold higher in patients with a history of RA (fully-adjusted OR, 1.66; 95% CI, 1.11–2.49; p = 0.014). The incidence rate of new-onset RA was estimated at 4.3 (95% CI, 2.5–6.8) and 2.4 (95% CI, 1.8–3.2) cases per 10,000 person-years among patients with HS and controls, respectively. The risk of RA was comparable between patients with HS and controls (fully-adjusted HR, 1.45; 95% CI, 0.77–2.72; p = 0.249). Compared to other patients with HS, those with HS and comorbid RA were older, had a higher prevalence of diabetes mellitus, hypertension, and hyperlipidemia, and had a comparable risk of all-cause mortality. In conclusions, a preexisting diagnosis of RA predisposes individuals to develop HS. Clinicians managing patients with HS and RA should be aware of this association. Further research is required to delineate the underlying pathomechanism of this observation.

Download Full-text

Gender- and age-related differences of statin use on incident dementia in patients with rheumatoid arthritis: a Nationwide population-based cohort study

Lipids in Health and Disease ◽

10.1186/s12944-021-01465-1 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Tsung-Kun Lin ◽

Jing-Yang Huang ◽

Lung-Fa Pan ◽

Gwo-Ping Jong

Keyword(s):

Rheumatoid Arthritis ◽

Cohort Study ◽

Subgroup Analysis ◽

Cox Regression ◽

Population Based ◽

Age Related ◽

Hazard Ratios ◽

Incident Dementia ◽

Gender And Age ◽

New Onset

Abstract Background Some observational studies have found a significant association between the use of statin and a reduced risk of dementia. However, the results of these studies are unclear in patients with rheumatoid arthritis (RA). This study is to determine the association between the use of statins and the incidence of dementia according to sex and age-related differences in patients with RA. Methods We conducted a nationwide retrospective cohort study using the Taiwan Health Insurance Review and Assessment Service database (2003–2016). The primary outcome assessed was the risk of dementia by estimating hazard ratios (HRs) and 95% confidence intervals (CIs). Multiple Cox regression was used to estimate the adjusted hazard ratio of new-onset dementia. Subgroup analysis was also conducted. Results Among the 264,036 eligible patients with RA aged > 40 years, statin users were compared with non-statin users by propensity score matching at a ratio of 1:1 (25,764 in each group). However, no association was found between the use of statins and the risk of new-onset dementia (NOD) in patients with RA (HR: 1.01; 95% CI: 0.97–1.06). The subgroup analysis identified the use of statin as having a protective effect against developing NOD in male and older patients. Conclusion No association was observed between the use of a statin and the risk of NOD in patients with RA, including patients of both genders and aged 40–60 years, but these parameters were affected by gender and age. The decreased risk of NOD in patients with RA was greater among older male patients. Use of a statin in older male (> 60 years) patients with RA may be needed in clinical practice to prevent dementia.

Download Full-text

Gender- and Age-related Differences of Statin Use on Incident Dementia in Patients with Rheumatoid Arthritis: A Nationwide Population-based Cohort Study

10.21203/rs.3.rs-249981/v1 ◽

2021 ◽

Author(s):

Tsung-Kun Lin ◽

Jing-Yang Huang ◽

Lung-Fa Pan ◽

Gwo-Ping Jong

Keyword(s):

Rheumatoid Arthritis ◽

Cohort Study ◽

Subgroup Analysis ◽

Older Patients ◽

Cox Regression ◽

Population Based ◽

Age Related ◽

Hazard Ratios ◽

Gender And Age ◽

New Onset

Abstract Background: Some observational studies have found a significant association between the use of statin and a reduced risk of dementia. However, the results of these studies are unclear in patients with rheumatoid arthritis (RA). This study is to determine the association between the use of statins and the incidence of dementia according to sex and age-related differences in patients with RA.Methods: We conducted a nationwide retrospective cohort study using the Taiwan Health Insurance Review and Assessment Service database (2003–2016). The primary outcome assessed was the risk of dementia by estimating hazard ratios (HRs) and 95% confidence intervals (CIs). Multiple Cox regression was used to estimate the adjusted hazard ratio of new-onset dementia. Subgroup analysis was also conducted.Results: Among the 264,036 eligible patients with RA aged > 40 years, statin users were compared with non-statin users by propensity score matching at a ratio of 1:1 (25,764 in each group). However, no association was found between the use of statins and the risk of new-onset dementia (NOD) in patients with RA (HR: 1.01; 95%CI: 0.97–1.06). The subgroup analysis identified the use of statin as having a protective effect against developing NOD in male and older patients.Conclusion: There is no association between the use of statin and the risk of NOD in patients with RA, but these parameters are influenced by gender and age. The decreased risk of NOD in patients with RA was greater among male and older patients. The use of statin in older male patients with RA for the prevention of dementia may be needed in clinical practice.

Download Full-text

Faculty Opinions recommendation of Delay in consultation with specialists for persons with suspected new-onset rheumatoid arthritis: a population-based study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1099331.555566 ◽

2008 ◽

Author(s):

Annelies Boonen

Keyword(s):

Rheumatoid Arthritis ◽

Population Based ◽

Population Based Study ◽

New Onset

Download Full-text

Prognostic value of long-term gamma-glutamyl transferase variability in individuals with diabetes: a nationwide population-based study

Scientific Reports ◽

10.1038/s41598-020-72318-7 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Da Young Lee ◽

Kyungdo Han ◽

Ji Hee Yu ◽

Sanghyun Park ◽

Ji A Seo ◽

...

Keyword(s):

Risk Factors ◽

Prognostic Value ◽

Population Based ◽

Gamma Glutamyl Transferase ◽

Population Based Study ◽

Gamma Glutamyl ◽

Hazard Ratios ◽

All Cause Mortality ◽

Glutamyl Transferase

Abstract We examined whether long-term gamma-glutamyl transferase (GGT) variability can predict cardiovascular disease (CVD) and mortality in individuals with diabetes. We included 698,937 Koreans diabetes patients older than 40 years without histories of CVD, chronic liver disease, or heavy alcoholics who received health exams supported by the Korean government more than once in 2009–2012 (baseline). We used Cox proportional analyses to estimate the risk of stroke, myocardial infarction (MI), and all-cause mortality until December 31, 2016, according to the quartiles of the average successive variability (ASV) of GGT measured during the five years before the baseline. A total 26,119, 15,103, and 39,982 cases of stroke, MI, and death, respectively, were found. GGT ASV quartile 4 had a significantly higher risk of stroke and all-cause mortality than quartile 1, with adjustment for risk factors, such as baseline glucose and GGT level, and comorbidities. Hazard ratios (95% confidence intervals) for GGT ASV quartile 4 were 1.06 (1.03–1.10) and 1.23 (1.20–1.27) for stroke and mortality, respectively. This significant association was shown consistently across the baseline GGT quartiles. GGT variability was related to the risk of stroke and all-cause mortality. The effect was most pronounced in all-cause mortality, irrespective of baseline GGT level.

Download Full-text

Increased mortality in adults with a history of juvenile rheumatoid arthritis: A population-based study

Arthritis & Rheumatism ◽

10.1002/1529-0131(200103)44:3<523::aid-anr99>3.0.co;2-1 ◽

2001 ◽

Vol 44 (3) ◽

pp. 523-527 ◽

Cited By ~ 29

Author(s):

Anthony R. French ◽

Tom Mason ◽

Audrey M. Nelson ◽

W. Michael O'Fallon ◽

Sherine E. Gabriel

Keyword(s):

Rheumatoid Arthritis ◽

Juvenile Rheumatoid Arthritis ◽

Population Based ◽

Population Based Study ◽

History Of

Download Full-text

Cardiovascular fitness in males at age 18 and risk of serious depression in adulthood: Swedish prospective population-based study

The British Journal of Psychiatry ◽

10.1192/bjp.bp.111.103416 ◽

2012 ◽

Vol 201 (5) ◽

pp. 352-359 ◽

Cited By ~ 67

Author(s):

Maria A. I. Åberg ◽

Margda Waern ◽

Jenny Nyberg ◽

Nancy L. Pedersen ◽

Ylva Bergh ◽

...

Keyword(s):

Bipolar Disorder ◽

Population Based ◽

Cardiovascular Fitness ◽

National Hospital ◽

Population Based Study ◽

Hazard Ratios ◽

Increased Risk ◽

History Of ◽

Future Risk ◽

Swedish Cohort

BackgroundStudies suggest a role for cardiovascular fitness in the prevention of affective disorders.AimsTo determine whether cardiovascular fitness at age 18 is associated with future risk of serious affective illness.MethodPopulation-based Swedish cohort study of male conscripts (n = 1 117 292) born in 1950–1987 with no history of mental illness who were followed for 3–40 years. Data on cardiovascular fitness at conscription were linked with national hospital registers to calculate future risk of depression (requiring in-patient care) and bipolar disorder.ResultsIn fully adjusted models low cardiovascular fitness was associated with increased risk for serious depression (hazard ratios (HR)=1.96, 95%, CI 1.71–2.23). No such association could be shown for bipolar disorder (HR=1.11, 95% CI 0.84–1.47).ConclusionsLower cardiovascular fitness at age 18 was associated with increased risk of serious depression in adulthood. These results strengthen the theory of a cardiovascular contribution to the aetiology of depression.

Download Full-text

A Population-Based Study of All-Cause Mortality and Cardiovascular Disease in Association With Prior History of Hypoglycemia Among Patients With Type 1 Diabetes

Diabetes Care ◽

10.2337/dc15-2418 ◽

2016 ◽

Vol 39 (9) ◽

pp. 1571-1578 ◽

Cited By ~ 29

Author(s):

Chin-Li Lu ◽

Hsiu-Nien Shen ◽

Susan C. Hu ◽

Jung-Der Wang ◽

Chung-Yi Li

Keyword(s):

Cardiovascular Disease ◽

Type 1 Diabetes ◽

Population Based ◽

Prior History ◽

Population Based Study ◽

All Cause Mortality ◽

History Of

Download Full-text

IGF1 as predictor of all cause mortality and cardiovascular disease in an elderly population

Acta Endocrinologica ◽

10.1530/eje-08-0452 ◽

2009 ◽

Vol 160 (1) ◽

pp. 25-31 ◽

Cited By ~ 69

Author(s):

Mikkel Andreassen ◽

Ilan Raymond ◽

Caroline Kistorp ◽

Per Hildebrandt ◽

Jens Faber ◽

...

Keyword(s):

Cardiovascular Disease ◽

Elderly Population ◽

Systolic Function ◽

Population Based ◽

Population Based Study ◽

Normal Systolic Function ◽

All Cause Mortality ◽

History Of ◽

Fourth Quartile ◽

Igf1 Signalling

BackgroundIGF1 is believed to influence ageing and development of cardiovascular disease (CVD) through complex mechanisms. Reduced IGF1 levels might be causally associated with conditions accompanying ageing including development of CVD. However, in animal models reduced GH–IGF1 signalling increases lifespan. Reduced IGF1 activity might also be associated with longevity in humans.ObjectiveThe objective was to investigate if plasma IGF1 levels were associated with all cause mortality, and the development of chronic heart failure (CHF) and a major CV event.Patients and designA population based study of 642 individuals, aged 50–89 years. Development of CHF was evaluated in 576 individuals with normal systolic function assessed by echocardiography and without the history of CHF or myocardial infarction. Development of the first major CV event was evaluated in 504 individuals with normal systolic function and without prevalent CVD. Outcomes were ascertained after 5 years using hospital discharge diagnoses.ResultsAdjustment for risk factors IGF1 values in the fourth quartile versus values below the fourth quartile was associated with increased mortality (n=103), hazard ratio (HR) 1.52 (95% confidence interval (CI) 1.01–2.28;P=0.044). IGF1 in the fourth quartile was also independently associated with risk of development of CHF (n=19), HR 5.02 (95% CI 2.00–12.64;P=0.001) but showed no association with the overall incidence of major CV events (n=58), HR 1.05 (95% CI 0.59–1.90;P=0.861).ConclusionsHigh IGF1 levels were independently associated with increased all cause mortality and risk of development of CHF, whereas no relation with the overall incidence of CVD was observed.

Download Full-text