Lipoxin A4 Activates Nrf2 Pathway and Ameliorates Cell Damage in Cultured Cortical Astrocytes Exposed to Oxygen-Glucose Deprivation/Reperfusion Insults

2015 ◽  
Vol 56 (4) ◽  
pp. 848-857 ◽  
Author(s):  
Le Wu ◽  
Hong-Hua Li ◽  
Qiang Wu ◽  
Sen Miao ◽  
Zi-Jian Liu ◽  
...  
Keyword(s):  
Cell Damage ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Lipoxin A4 ◽  
Nrf2 Pathway ◽  
Cortical Astrocytes

scholarly journals Neuroprotective Effect of Metaplexis japonica against in vitro Ischemia Model

2019 ◽  
Vol 3 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Nirmala Jamarkattel-Pandit ◽  
Hocheol Kim
Keyword(s):  
Cell Damage ◽  
Neuroprotective Effect ◽  
Ethanol Extract ◽  
Glucose Deprivation ◽  
Ethyl Acetate Fraction ◽  
Perennial Herb ◽  
Oxygen Glucose Deprivation ◽  
In Vitro Ischemia ◽  
Ht22 Cell

Metaplexis japonica (Apocynaceae) is a perennial herb, extensively used in traditional medicinal system for various diseases. The purpose of the study was to evaluate the protective effect of M. japonica against in vitro ischemia. In the present study, 70% ethanol extract of M. japonica was fractionated with different polarity solvents. For in vitro ischemia, oxygen-glucose deprivation followed by reoxygenation (OGD-R) in cells was used to investigate the effects of M. japonica and its fractions. For oxidative stress model, Hydrogen peroxide (H2 O2 ) induced cell death was studied in HT22 cell line. M. japonica and its fractions significantly reduced the HT22 cell damage, which was induced by 4 hrs of OGD followed by 24 hrs of reoxygenation and 24 hrs of H2 O2, respectively. The effectiveness of ethyl acetate fraction was higher than other fractions/crude extract. Our results suggest that M. japonica could be a neuroprotective agent for the treatment of stroke. Key words: Metaplexis japonica, Stroke, Oxygen-glucose deprivation, Neuroprotection

scholarly journals Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons

2019 ◽  
Vol 52 (4) ◽  
pp. 462 ◽  
Author(s):  
Ji-Young Yoo ◽  
Han-Byeol Kim ◽  
Seung-Yeon Yoo ◽  
Hong-Il Yoo ◽  
Dae-Yong Song ◽  
...  
Keyword(s):  
Hippocampal Neurons ◽  
Cell Damage ◽  
Neuronal Cell ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Neuregulin 1 ◽  
Primary Hippocampal Neurons

Effect of baicalin on oxygen–glucose deprivation-induced endothelial cell damage

Neuroreport ◽  
2017 ◽  
Vol 28 (6) ◽  
pp. 299-306 ◽  
Author(s):  
Si Luo ◽  
Shi Li ◽  
Lei Zhu ◽  
Shu-Huan Fang ◽  
Jun-Li Chen ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Damage ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Endothelial Cell Damage
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